ChemicalBook > CAS DataBase List > 6-Aminopyridine-3-carboxamide

6-Aminopyridine-3-carboxamide

Product Name
6-Aminopyridine-3-carboxamide
CAS No.
329-89-5
Chemical Name
6-Aminopyridine-3-carboxamide
Synonyms
6-AN;6-ANA;U-8774;fda0121;SR-4388;FDA 0121;nsc21206;NSC 21206;NSC-13128;BRN 2034522
CBNumber
CB9224555
Molecular Formula
C6H7N3O
Formula Weight
137.14
MOL File
329-89-5.mol
More
Less

6-Aminopyridine-3-carboxamide Property

Melting point:
245-248 °C (lit.)
Boiling point:
251.97°C (rough estimate)
Density 
1.2620 (rough estimate)
refractive index 
1.6910 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
insoluble in H2O; insoluble in EtOH; ≥13.7 mg/mL in DMSO
form 
powder to crystal
pka
15.66±0.50(Predicted)
color 
White to Light yellow
Water Solubility 
Soluble in Dimethyl sulfoxide (DMSO). Insoluble in water.
BRN 
116042
CAS DataBase Reference
329-89-5(CAS DataBase Reference)
NIST Chemistry Reference
Nicotinamide, 6-amino-(329-89-5)
EPA Substance Registry System
6-Aminonicotinamide (329-89-5)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
61
Safety Statements 
53-45
RIDADR 
1655
WGK Germany 
3
RTECS 
US4550000
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
II
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A68203
Product name
6-Aminonicotinamide
Purity
99%
Packaging
1g
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
A68203
Product name
6-Aminonicotinamide
Purity
99%
Packaging
5g
Price
$555
Updated
2024/03/01
TCI Chemical
Product number
A0986
Product name
6-Aminonicotinamide
Purity
>99.0%(T)
Packaging
1g
Price
$110
Updated
2024/03/01
TCI Chemical
Product number
A0986
Product name
6-Aminonicotinamide
Purity
>99.0%(T)
Packaging
5g
Price
$354
Updated
2024/03/01
Alfa Aesar
Product number
L06692
Product name
6-Aminonicotinamide, 99%
Packaging
1g
Price
$59.65
Updated
2024/03/01
More
Less

6-Aminopyridine-3-carboxamide Chemical Properties,Usage,Production

Uses

6-Aminonicotinamide induces apoptosis in tumor cells. It is clinically used in disseminated neoplastic disease. It also acts as 6-phosphogluconate dehydrogenase inhibitor. It aids in the treatment of psoriasis. It is used as cancer chemotherapeutic drug in animals.

Uses

antineoplastic, apoptosis inducer

Definition

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.

General Description

White crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

An amine and amide. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-Aminopyridine-3-carboxamide emits toxic fumes of NOx.

Fire Hazard

Flash point data for 6-Aminopyridine-3-carboxamide are not available; however, 6-Aminopyridine-3-carboxamide is probably combustible.

Biological Activity

ki: 0.46 μm6-aminonicotinamide is a 6-phosphogluconate dehydrogenase inhibitor.6-phosphogluconate dehydrogenase, an enzyme in the pentose phosphate pathway, can produce ribulose 5-phosphate from 6-phosphogluconate. 6-phosphogluconate dehydrogenase is also an oxidative carboxylase catalyzing the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of nadp.

in vitro

6-aminonicotinamide could be metabolized to 6-amino-nad(p+), a competitive inhibitor of nad(p+)-requiring processes, especially the pentose phosphate pathway enzyme, 6-phosphogluconate dehydrogenase. moreove, 6-aminonicotinamide as a single agent could cause a significant inhibition of glycolytic flux but had no effect on the pentose phosphate pathway. 31p-nmr studies of perifused rif-1 cells indicated that 4 h of exposure to 6-aminonicotinamide was enough to cause significant accumulation of 6-phosphogluconate, the substrate for this enzyme [1].

in vivo

the influence of 6-aminonicotinamide on the g-6-p-dh- and 6-pg-dh-levels of the pentose phosphate pathway in the kidney was investigated. following i.p. administration of 6-aminonicotinamide at 6 mg/kg, the 6-pg-level rose from a value less than 10 nmoles/g to 1000 nmoles/g fresh weight within 24 h. in addition, at the end of the assay, after 7 days, a 6-pg-concentration of about 150 nmoles/g fresh weight was still seen. moreove, the g-6-p level simultaneously rose with the 6-pg-level to about 150% of the control level and returned to normal on the 5th day [2].

References

[1] street, j. c.,alfieri, a.a. and koutcher, j.a. quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in rif-1 tumor cells in vitro. cancer research 57, 3956-3962 (1997).
[2] lange, k. and proft, e.r. inhibition of the 6-phosphogluconate dehydrogenase in the rat kidney by 6-aminonicotinamide. naunyn-schmiedeberg's archives of pharmacology 267, 177-180 (1970).

6-Aminopyridine-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

6-Aminopyridine-3-carboxamide Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Anisyn, Inc.
Tel
--
Fax
--
Email
sales@anisyn.com
Country
United States
ProdList
863
Advantage
0
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
Tyger Scientific Inc.
Tel
--
Fax
--
Email
sales@tygersci.com
Country
United States
ProdList
402
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Chemiplus Corporation
Tel
--
Fax
--
Email
okazaki@chemiplus.com
Country
United States
ProdList
3198
Advantage
38
Kingchem Inc.
Tel
--
Fax
--
Email
s.wang@kingchem.com
Country
United States
ProdList
757
Advantage
60
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Chontech, Inc.
Tel
--
Fax
--
Email
chontech@yahoo.com
Country
United States
ProdList
1101
Advantage
30
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
More
Less

View Lastest Price from 6-Aminopyridine-3-carboxamide manufacturers

Honest Joy Holdings Limited
Product
6-Aminonicotinamide 329-89-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
100 tons
Release date
2022-02-20
Career Henan Chemical Co
Product
6-Aminopyridine-3-carboxamide 329-89-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-09

329-89-5, 6-Aminopyridine-3-carboxamideRelated Search:


  • 2-Amino-5-carbamoylpyridine
  • 3-Pyridinecarboxamide, 6-amino-
  • 6-amino-3-pyridinecarboxamid
  • 6-amino-nicotinamid
  • 6-Aminonicotinic acid amide
  • 6-aminonicotinicacidamide
  • 6-Amino-nicotinsaeureamid
  • 6-Aminonikotinsaeureamid
  • 6-AN
  • 6-ANA
  • Aminonicotinamide
  • FDA 0121
  • fda0121
  • NSC 21206
  • nsc21206
  • U-8774
  • 2-AMINOPYRIDINE-5-CARBOXAMIDE
  • 6-AMINOPYRIDINE-3-CARBOXAMIDE
  • 6-AMINONICOTINAMIDE
  • 6-AMINO-3-PYRIDINECARBOXAMIDE
  • 6-Aminoincotinamide
  • 6-aminonicotinic amide
  • 6-Aminonicotinamide 95+%
  • 3-Pyridinecarboxamide,6-amino-(9CI)
  • NSC-13128
  • SR-4388
  • 6-azanylpyridine-3-carboxamide
  • Nicotinamide, 6-amino-
  • Nicotinamide, 6-amino- (8CI)
  • WLN: T6NJ BZ EVZ
  • 6-Aminonikotinsaeureamid [German]
  • 6-Aminonitoinamide
  • 6-Aminonicotinamide &gt
  • Antioxidant 40
  • BRN 2034522
  • Apremilast Impurity 126
  • 329-89-5
  • Heterocyclic Building Blocks
  • Pyridines
  • Building Blocks
  • C6
  • Heterocyclic Compounds
  • Building Blocks
  • C6
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • AMIDE
  • Pyridine series
  • Amines
  • Pyridines