ChemicalBook > CAS DataBase List > 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid

Product Name
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid
CAS No.
10314-98-4
Chemical Name
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid
Synonyms
Z-INP-OH;Z-NIP-OH;Z-PIC(4)-OH;Cbz-DL-Inp-OH;BUTTPARK 75\50-27;RARECHEM AL BE 0487;TIMTEC-BB SBB003079;Z-ISONIPECOTIC ACID;N-CBZ-ISONIPECOTIC ACID;1-Cbz-isonipecotic Acid
CBNumber
CB9228694
Molecular Formula
C14H17NO4
Formula Weight
263.29
MOL File
10314-98-4.mol
More
Less

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Property

Melting point:
78 °C
Boiling point:
443.9±45.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
4.55±0.20(Predicted)
color 
White to Almost white
InChI
InChI=1S/C14H17NO4/c16-13(17)12-6-8-15(9-7-12)14(18)19-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H,16,17)
InChIKey
URTPNQRAHXRPMP-UHFFFAOYSA-N
SMILES
N1(C(OCC2=CC=CC=C2)=O)CCC(C(O)=O)CC1
CAS DataBase Reference
10314-98-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
26-36/37/39-37/39
HazardClass 
IRRITANT
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
C2563
Product name
1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
C2563
Product name
1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$103
Updated
2025/07/31
TCI Chemical
Product number
C2563
Product name
1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$341
Updated
2025/07/31
TRC
Product number
B130010
Product name
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylicAcid
Packaging
500mg
Price
$60
Updated
2021/12/16
Usbiological
Product number
269535
Product name
N-Cbz-Piperidine-4-carboxylic acid
Packaging
5g
Price
$438
Updated
2021/12/16
More
Less

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Whtie powder

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 42, p. 147, 1994 DOI: 10.1248/cpb.42.147

Synthesis

498-94-2

501-53-1

10314-98-4

NaHCO3 (1.5 eq.) and Na2CO3 (1.5 eq.) were added to 4-piperidinecarboxylic acid (1.29 g, 10 mmol) in a mixed solvent of acetonitrile/water (2:3, 0.1 M) and the pH was adjusted to 10-11. The reaction mixture was cooled down to 0 °C and then benzyl chloroformate (1.42 mL, 1.7 g, 10 mmol) was slowly added dropwise. After the dropwise addition, the reaction solution was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction mixture was acidified to pH ~2-3 by dropwise addition of aqueous 1N HCl. Subsequently, acetonitrile was removed by evaporation under reduced pressure, and the aqueous phase was extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 1-(benzyloxycarbonyl)piperidine-4-carboxylic acid in quantitative yield, and the product was used directly in the next step of the reaction.

References

[1] Synlett, 2017, vol. 28, # 3, p. 376 - 380
[2] Tetrahedron, 1997, vol. 53, # 32, p. 10983 - 10992
[3] Patent: US2010/152158, 2010, A1. Location in patent: Page/Page column 31
[4] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 60
[5] Patent: US2010/222324, 2010, A1. Location in patent: Page/Page column 57

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Isonipecotic acid Benzyl chloroformate Sodium hydroxide

Preparation Products

More
Less

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Suppliers

Americas 1 Belgium 1 China 197 Europe 3 France 3 Germany 9 India 13 Japan 5 South Korea 1 Spain 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 15 United States 52 Global 305
Shanghai Hobor Chemical Co., Ltd
Tel
021-57790084; 13918007836
Fax
021-51685238
Email
sales@hoborchem.com
Country
China
ProdList
392
Advantage
60
Shanghai Tuolei Chemical Reagents Co., Ltd.
Tel
86-021-50318510
Fax
021-58650104
Country
China
ProdList
69
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2806
Advantage
65
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
1009
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
15928766785 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
1987
Advantage
55
ShangHai Zexin Chemical Technology Co., Ltd.
Tel
021-60136491 15901897992
Fax
021-60136492
Country
China
ProdList
455
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3853
Advantage
58
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Sichuan Ampebiochem Co., Ltd.
Tel
028-65294243 13981822079;18682730901
Email
sales@ampebiochem.com
Country
China
ProdList
1000
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2001
Advantage
56
Shanghai AQBioPharma Co., Ltd.
Tel
13661411401
Fax
51370935-8011
Email
yinglv.que@aqbiopharma.com.cn
Country
China
ProdList
2930
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Bellen Chemistry Co., Ltd.
Tel
010-60400365-8001 15910885229
Fax
010-60400361
Email
service@bellenchem.com
Country
China
ProdList
4514
Advantage
60
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
More
Less

View Lastest Price from 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid manufacturers

Anhui Zhongda Biotechnology Co., Ltd
Product
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 10314-98-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100tons
Release date
2023-10-24
Xingtai Haoxun Import and Export Trade Co., Ltd.
Product
1-Cbz-piperidine-4-carboxylic Acid 10314-98-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10tons
Release date
2020-07-16
Jinan Ande Pharmaceutical Co.,Ltd.
Product
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 10314-98-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100
Release date
2021-12-23

10314-98-4, 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acidRelated Search:

CARBONYL SULFIDE PYRAZOPHOS Nequinate Trimethoprim Haloperidol 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 9-Phenyl-9H-carbazol-3-ylboronic acid 1-Cbz-4-Piperidone Ascoric Acid 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 1-N-Cbz-4-Methylpiperidine-4-carboxylic acid Diphenoxylate Carbonyl iron powder 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER 3-Boc-Amino-1-Cbz-piperidine-3-carboxylic acid 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-2-CARBOXYLIC ACID 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-3-CARBOXYLIC ACID 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-2-CARBOXYLIC ACID

  • 1-[(BENZYLOXY)CARBONYL]-4-PIPERIDINECARBOXYLIC ACID
  • 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-4-CARBOXYLIC ACID
  • RARECHEM AL BE 0487
  • 1-CBZ-4-PIPERIDINECARBOXYLIC ACID
  • 1-Cbz-4-piperidinecarboxylic Acid 1-Carbobenzoxyisonipecotic Acid 1-Cbz-isonipecotic Acid
  • N - CBZ - 4 - piperidine forMic acid
  • PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER
  • N-CBZ-PIPERIDINE-4-CARBOXYLIC ACID
  • N-CBZ-ISONIPECOTIC ACID
  • N-CBZ-4-PIPERIDINECARBOXYLIC ACID
  • N-CARBOBENZOXY-HEXAHYDROISONICOTINIC ACID
  • N-CARBOBENZYLOXY-4-PIPERIDINECARBOXYLIC ACID
  • N-CARBOBENZOXY-PIPEREDINE-4-CARBOXYLIC ACID
  • N-BENZYLOXYCARBONYL-PIPERIDINE-4-CARBOXYLIC ACID
  • N-BENZYLOXYCARBONYL-ISONIPECOTIC ACID
  • Z-ISONICOT(HEXAHYDRO)-OH
  • Z-INP-OH
  • Z-PIC(4)-OH
  • TIMTEC-BB SBB003079
  • Cbz-DL-Inp-OH
  • Piperidine-4-carboxylic acid, N-CBZ protected
  • 1-[(Benzyloxy)carbobyl]-3-piperidinecarbozylicacid
  • N-Cbz-Piperidine-4-Carboxylic
  • Piperidine-4-carboxylic acid, N-CBZ protected 97%
  • Piperidine-4-carboxylicacid,N-CBZprotected97%
  • Z-ISONIPECOTIC ACID
  • Z-NIP-OH
  • 1-N-CBZ-PIPERIDINE-4-CARBOXYLIC ACID
  • 1-CBZ-PIPERIDINE-4-CARBOXYLIC ACID
  • 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid, 1-[(Benzyloxy)carbonyl]-4-carboxypiperidine
  • 1-((benzyloxy)carbonyl)piperidin-4-carboxylic acid
  • 1,4-Piperidinedicarboxylic acid, 1-(phenylMethyl) ester
  • 1-Carbobenzoxy-4-piperidinecarboxylic Acid
  • BUTTPARK 75\50-27
  • 1-Z-PIPERIDINE-4-CARBOXYLIC ACID
  • 1-Carbobenzoxy-4-piperidinecarboxylic Acid &gt
  • 1-Benzyloxycarbonylisonipecotic Acid
  • 1-Carbobenzoxyisonipecotic Acid
  • 1-Cbz-isonipecotic Acid
  • 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid ISO 9001：2015 REACH
  • 1-(Carbobenzoxy)piperidine-4-carboxylic acid
  • Z-Isonipecotic acid, 98%+
  • Z-Isonipecotic Acid extrapure, 99%
  • 1-phenylmethoxycarbonylpiperidine-4-carboxylic acid
  • 1-(Phenylmethyl) 1,4-piperidinedicarboxylate
  • Benzyl Benzoate Impurity 14
  • 10314-98-4
  • 78190-11-2
  • C14H16NO4
  • Carboxylic Acids
  • Pyrans, Piperidines & Piperazines
  • Carboxylic Acids
  • Pyrans, Piperidines &Piperazines
  • Piperidine
  • pharmacetical