ChemicalBook > CAS DataBase List > 4-Hydroxybenzophenone

4-Hydroxybenzophenone

Product Name
4-Hydroxybenzophenone
CAS No.
1137-42-4
Chemical Name
4-Hydroxybenzophenone
Synonyms
POB;P-HYDROXYBENZOPHENONE;4-Hydroxydiphenylketone;NSC 1887;ENCL-001;benzoylphenol;Ospemifene INT;4-BENZOYLPHENOL;P-BENZOYLPHENOL;PARA-BENZOYLPHENOL
CBNumber
CB9237221
Molecular Formula
C13H10O2
Formula Weight
198.22
MOL File
1137-42-4.mol
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4-Hydroxybenzophenone Property

Melting point:
132-135 °C(lit.)
Boiling point:
260-262°C 42mm
Density 
1.1184 (rough estimate)
vapor pressure 
0Pa at 20℃
refractive index 
1.5954 (estimate)
Flash point:
260-262°C/24mm
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Powder
pka
8.14±0.13(Predicted)
color 
White to beige to brown
Water Solubility 
Insoluble in water.
BRN 
777776
LogP
1.6 at 35℃
CAS DataBase Reference
1137-42-4(CAS DataBase Reference)
NIST Chemistry Reference
Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4)
EPA Substance Registry System
Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37-24/25-36
WGK Germany 
2
RTECS 
PC4959775
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29145000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H20202
Product name
4-Hydroxybenzophenone
Purity
98%
Packaging
25g
Price
$67.8
Updated
2024/03/01
Sigma-Aldrich
Product number
H20202
Product name
4-Hydroxybenzophenone
Purity
98%
Packaging
100g
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20661
Product name
4-Hydroxybenzophenone
Purity
for synthesis
Packaging
25g
Price
$50.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20661
Product name
4-Hydroxybenzophenone
Purity
for synthesis
Packaging
100g
Price
$169
Updated
2024/03/01
TCI Chemical
Product number
H0222
Product name
4-Hydroxybenzophenone
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$45
Updated
2024/03/01
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4-Hydroxybenzophenone Chemical Properties,Usage,Production

Chemical Properties

white to beige fine crystalline powder

Uses

4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.

Uses

Metabolite of benzophenone.

Definition

ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.

Preparation

Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0

Flammability and Explosibility

Not classified

Purification Methods

Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]

4-Hydroxybenzophenone Preparation Products And Raw materials

Raw materials

Aluminum chloride Phenyl benzoate

Preparation Products

Clomiphene Citrate 4-[2-(diethylamino)ethoxy]benzophenone alpha-[4-[2-(diethylamino)ethoxy]phenyl]-alpha-phenylphenethyl alcohol
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4-Hydroxybenzophenone Suppliers

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View Lastest Price from 4-Hydroxybenzophenone manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
4-Hydroxybenzophenone 1137-42-4
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-24
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
4-Hydroxybenzophenone 1137-42-4
Price
US $99.00-66.00/kg
Min. Order
0.0010000000474974513kg
Purity
99%
Supply Ability
5000
Release date
2024-08-19
Hebei Weibang Biotechnology Co., Ltd
Product
4-Hydroxybenzophenone 1137-42-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25

1137-42-4, 4-HydroxybenzophenoneRelated Search:

Acetaldehyde HYDROXYAPATITE TYPE I Diphenyl ether Phenyl salicylate Glycolic acid Benzophenone hydrazone Benzophenone PHENYL VALERATE Hydroxy silicone oil 4-Chlorobenzophenone 4-Methoxybenzophenone AKOS BB-9928 PHENYL RESIN 2,3,3',4'-TETRAMETHOXYBENZOPHENONE 3,4-Dihydroxybenzophenone 2,4-Dihydroxybenzophenone 2,6-DIHYDROXYANTHRAQUINONE 2,2'-Dihydroxy-4-methoxybenzophenone

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