(+)-Polyneuridine

Product Name: (+)-Polyneuridine
CAS No.: 639-36-1
Chemical Name: (+)-Polyneuridine
Synonyms: Rhazin;Rhazine;Akuammidine;(+)-Polyneuridine;SARPAGAN-16-CARBOXYLIC ACID17-HYDROXY-,METHYL ESTER;17-Hydroxysarpagane-16-carboxylic acid methyl ester
CBNumber: CB92397389
Molecular Formula: C21H24N2O3
Formula Weight: 352.43
MOL File: 639-36-1.mol

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(+)-Polyneuridine Property

Melting point:: 243-246℃
Boiling point:: 513.0±50.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
pka: 14.79±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD32000741
Product name: Akuammidine
Purity: 95+%
Packaging: 5mg
Price: $922
Updated: 2021/12/16

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(+)-Polyneuridine Chemical Properties,Usage,Production

Uses

Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties[1][2].

IC 50

κ Opioid Receptor/KOR

References

[1] Yuanyuan Hou, et al. Microfractionation Bioactivity-Based Ultra Performance Liquid Chromatography/Quadrupole Time-Of-Flight Mass Spectrometry for the Identification of Nuclear factor-κB Inhibitors and β2 Adrenergic Receptor Agonists in an Alkaloidal Extract of the Folk Herb Alstonia Scholaris. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:98-104. DOI:10.1016/j.jchromb.2012.10.004
[2] J R Menzies, et al. Opioid Activity of Alkaloids Extracted From Picralima Nitida (Fam. Apocynaceae). Eur J Pharmacol. 1998 May 29;350(1):101-8. DOI:10.1016/s0014-2999(98)00232-5

(+)-Polyneuridine Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-Polyneuridine Suppliers

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639-36-1, (+)-PolyneuridineRelated Search:

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17-Hydroxysarpagane-16-carboxylic acid methyl ester

Rhazin

SARPAGAN-16-CARBOXYLIC ACID17-HYDROXY-,METHYL ESTER

Akuammidine

Rhazine

(+)-Polyneuridine

639-36-1