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Nitrilotriacetic acid

Product Name
Nitrilotriacetic acid
CAS No.
139-13-9
Chemical Name
Nitrilotriacetic acid
Synonyms
NTA;TRIGLYCINE;NITRILOTRIACETATE;NTA acid;TRILON A;Nitrilotriacetic;NITRILOACETIC ACID;2,2',2''-Nitrilotriacetic acid;nci-c02766;NITRILOACETATE
CBNumber
CB9241989
Molecular Formula
C6H9NO6
Formula Weight
191.14
MOL File
139-13-9.mol
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Nitrilotriacetic acid Property

Melting point:
245 °C (dec.)(lit.)
Boiling point:
326.86°C (rough estimate)
Density 
1.5784 (rough estimate)
vapor pressure 
0-0Pa at 20-25℃
refractive index 
1.4860 (estimate)
Flash point:
100 °C
storage temp. 
2-8°C
solubility 
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
form 
Powder
pka
3.03, 3.07, 10.70(at 20℃)
color 
White
Water Solubility 
Insoluble. <0.01 g/100 mL at 23 ºC
λmax
λ: 260 nm Amax: 1.5
λ: 280 nm Amax: 0.05
Merck 
14,6579
BRN 
1710776
LogP
-3.81 at 25℃
CAS DataBase Reference
139-13-9(CAS DataBase Reference)
NIST Chemistry Reference
Nitrilotriacetic acid(139-13-9)
IARC
2B (Vol. 48, 73) 1999
EPA Substance Registry System
Nitrilotriacetic acid (139-13-9)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-36-40-36/37/38-45-20/21/22
Safety Statements 
26-36/37-45-36/37/39-53
RIDADR 
2811
WGK Germany 
2
RTECS 
AJ0175000
F 
21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29224995
Hazardous Substances Data
139-13-9(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1100 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
72559
Product name
Nitrilotriacetic acid
Purity
BioUltra, ≥99.0% (T)
Packaging
100g
Price
$85.4
Updated
2024/03/01
Sigma-Aldrich
Product number
1463950
Product name
Nitrilotriacetic acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$420
Updated
2024/03/01
TCI Chemical
Product number
N0098
Product name
Nitrilotriacetic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$22
Updated
2024/03/01
TCI Chemical
Product number
N0098
Product name
Nitrilotriacetic Acid
Purity
>98.0%(T)
Packaging
500g
Price
$65
Updated
2024/03/01
Alfa Aesar
Product number
A11936
Product name
Nitrilotriacetic acid, 99%
Packaging
100g
Price
$30.8
Updated
2024/03/01
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Nitrilotriacetic acid Chemical Properties,Usage,Production

Chemical Properties

Nitrilotriacetic acid, also known as NTA, is a white crystalline powder. It can dissolve in ammonia and alkali solutions while being slightly soluble in hot water. However, it is insoluble in water and most organic solvents. NTA can form mono-, di-, and tribasic salts, all of which are soluble in water. Combustible. 70% biodegradable.

Uses

Used in sequestration of metals; chelometric analysis.

Uses

Nitrilotriacetic acid is a chelating agent which forms coordination compounds with metal ions. Nitrilotriacetic acid is used in complexometric titrations and as well as for protein isolation and purification in the His-tag method. This compound is a contaminant of emerging concern (CECs).

Definition

ChEBI: Nitrilotriacetic acid is a tricarboxylic acid and a NTA. It has a role as a nephrotoxic agent and a carcinogenic agent. It is a conjugate acid of a nitrilotriacetate(1-).

Preparation

The synthesis of nitrilotriacetic acid involves the following steps:
Chloroacetic acid is reacted with sodium hydroxide to produce sodium chloroacetate.
Sodium chloroacetate then reacts with ammonium chloride to form sodium aminotriacetate.
The resulting sodium aminotriacetate is acidified to obtain nitrilotriacetic acid.

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 46, 1950 DOI: 10.1021/jo01147a008

General Description

Odorless white solid. Sinks in and mixes with water.

Air & Water Reactions

Water Insoluble.

Reactivity Profile

Nitrilotriacetic acid is incompatible with strong oxidizers, aluminum, copper, copper alloy and nickel. Nitrilotriacetic acid is also incompatible with strong bases.

Hazard

Possible carcinogen.

Health Hazard

Toxicity and health hazard of these compounds are low. Contact with eyes causes irritation.

Fire Hazard

Flash point data for Nitrilotriacetic acid are not available; however, Nitrilotriacetic acid is probably combustible.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Nitrilotriacetic (NTA) has the ability to link with histidine side chain of proteins. It can be used in fluorescent labelling, hexahistidine (His6)-tagged proteins for purification and surface immobilization.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Nitrilotriacetic acid (NTA) was used as a phosphate replacement in laundry detergents in the late 1960s. In 1971, the use of NTA was discontinued. The possibility of resumed use arose in 1980. NTA is now used in laundry detergents in states where phosphates are banned. NTA is also used as a boiler feed-water additive at a maximum use level of 5 ppm of trisodium salt. Currently, the remaining nondetergent uses of NTA are for water treatment, textile treatment; metal plating and cleaning; and pulp and paper processing.

Carcinogenicity

Nitrilotriacetic acid is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise it from water and dry it at 110o. [Beilstein 4 IV 2441.]

Incompatibilities

Dust may form explosive mixture with air. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Attacks aluminum, copper, copper alloy and nickel.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Nitrilotriacetic acid Preparation Products And Raw materials

Raw materials

Film evaporator Chloroacetic acid Ammonium chloride Sulfuric acid Sodium chloroacetate

Preparation Products

N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)IMINODIACETIC ACID amino trimethylene phosphoric acid 1,5-Diaminobiurea
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View Lastest Price from Nitrilotriacetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Nitrilotriacetic acid 139-13-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-15
Hebei Weibang Biotechnology Co., Ltd
Product
Nitrilotriacetic acid 139-13-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
Nitrilotriacetic acid 139-13-9
Price
US $20.00-9.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-10

139-13-9, Nitrilotriacetic acidRelated Search:

N,N-BIS(CARBOXYMETHYL)-L-GLUTAMIC ACID TETRASODIUM SALT Nitrilotriacetic acid NITRILOTRIACETIC ACID TRISODIUM SALT MONOHYDRATE NITRILOTRIACETIC ACID DISODIUM SALT,NITRILOTRIACETIC ACID DISODIUM*SIGMA GRA DE,Nitrilotriacetic acid, disodium salt, 99+% N,N-BIS(CARBOXYLATOMETHYL)ALANINE TRISODIUM SALT IDRANAL(R) V,IDRANAL?V,IDRANAL V FUER ANALYSE 2,2',2''-Nitrilotriacetic acid trisodium salt,NITRILOTRIACETIC ACID, TRI NA SALT,NITRILOTRIACETIC ACID TRISODIUM SALT IDRANAL II-ZINC R. G. idranal ii-zinc,IDRANAL&#8482; II-zinc,Zinc-IDRANAL? disodium salt IDRANAL(R),IDRANAL II R. G.,IDRANAL(R) II,idranal ii IDRANAL(R) II-MAGNESIUM,IDRANAL II-MAGNESIUM R. G.,idranal ii-magnesium IDRANAL(R) II COPPER IDRANAL(R) VI,IDRANAL VI R. G. IDRANAL VII IDRANAL IV R. G.,idranal iv 0,1 MOL IDRANAL III FIXANAL,IDRANAL(R) IDRANAL 100 (IDRANAL III SOLUTION) FOR W ATER HARDNESS DETERMINATION IDRANAL(R) II-ZINC

  • nci-c02766
  • nitrilo-2,2’,2’’-triaceticacid
  • Nitrilortiaceticacid
  • nitrilotri-aceticaci
  • nitrilotris(methylenecarboxylicacid)
  • Noname
  • titriplexi
  • tri(carboxymethyl)amine
  • Triglycolamidicacid
  • ai3-52483
  • chel300
  • complexoni
  • Glycine,N,N-bis(carboxyme
  • hampshirentaacid
  • komplexoni
  • kyselinanitrilotrioctova
  • kyselinanitrilotrioctova(czech)
  • n,n-bis(carboxymethyl)-glycin
  • Trilone A
  • Ammonium triacetic acid,Triglycollamic acid,α,α',α”-Trimethylaminetricarboxylic acid,chelaton I,NTA
  • NITRILOTRIACETIC ACID 98+% &
  • IDRANAL I R. G.
  • NITRILOTRIACETIC ACID ACS REAGENT
  • NITRILOTRIACETIC ACID, 98+%, A.C.S. REAG ENT
  • NITRILOTRIACETIC ACID FREE ACID*SIGMA GR ADE
  • NITRILOTRIACETIC ACID -PLANT CELL*CULTUR E TESTED
  • NITRILOTRIACETIC ACID, ACS, FOR COMPLEXO METRY
  • NitrilotriaceticAcidGr
  • NitrilotriaceticAcid,NTA
  • Nitrilotriacetic
  • Glycine, N,N-bis(carboxymethyl)-
  • idranal i
  • nitrilotriacetic acid, acs
  • NITRILOTRIACETICACID,CP
  • NITRYLTRIACETICACID
  • NITRILOACETATE
  • NITRILOTRIACETATEMONOHYDRATE
  • NITRILOTRIACETATEACID
  • NITRILOTRIACETATE
  • Glycinate zinc
  • NITRILOTRIACETIC ACID FREE ACID*SIGM
  • Nitrilotriacetic acidACS reagent, ≥ 98.0% (Titration)
  • Triglycollamic Acid N,N-Bis(carboxymethyl)glycine NTA Tris(carboxymethyl)amine Triglycine
  • Titriplex I for analysis (nitrilotriacetic acid)
  • NITRILOTRIACETIC ACID REAGENT (ACS)
  • Edetate Disodium Impurity 1
  • Nitrilotriacetic acid, 99%, ACS reagent
  • NTA, Aminotriacetic acid
  • NTA acid
  • Trimethylamine-1.1’,1’’-tricarboxylicacid
  • versenentaacid
  • NTA
  • NITRILOACETIC ACID
  • NITRILOTRIACETIC ACID
  • N,N-BIS(CARBOXYMETHYL)GLYCINE
  • TRILON A
  • TRIGLYCINE
  • TRIGLYCOLLAMIC ACID