1-CHLORO-7-METHYLISOQUINOLINE

Product Name: 1-CHLORO-7-METHYLISOQUINOLINE
CAS No.: 24188-80-5
Chemical Name: 1-CHLORO-7-METHYLISOQUINOLINE
Synonyms: 1-Chlor-7-methyl-isochinolin;1-CHLORO-7-METHYLISOQUINOLINE;Isoquinoline, 1-chloro-7-methyl-
CBNumber: CB92452462
Molecular Formula: C10H8ClN
Formula Weight: 177.63
MOL File: 24188-80-5.mol

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1-CHLORO-7-METHYLISOQUINOLINE Property

Boiling point:: 284.8±20.0 °C(Predicted)
Density: 1.225±0.06 g/cm3(Predicted)
pka: 2.31±0.33(Predicted)

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C374458
Product name: 1-chloro-7-methylisoquinoline
Packaging: 100mg
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: OR964809
Product name: 1-Chloro-7-methylisoquinoline
Purity: 95%
Packaging: 100mg
Price: $182
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-LW
Product name: 1-Chloro-7-methylisoquinoline
Purity: 95%
Packaging: 100mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC159688
Product name: 1-Chloro-7-methylisoquinoline
Packaging: 250mg
Price: $275
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-LW
Product name: 1-Chloro-7-methylisoquinoline
Purity: 95%
Packaging: 250mg
Price: $360
Updated: 2021/12/16

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1-CHLORO-7-METHYLISOQUINOLINE Chemical Properties,Usage,Production

Synthesis

26829-47-0

24188-80-5

General procedure for the synthesis of 1-chloro-7-methylisoquinoline from 1-hydroxy-7-methylisoquinoline: phosphorus oxychloride (POCl3, 10 mL) was mixed with 7-methylisoquinolin-1-ol (3.55 g, 22.3 mmol) under the protection of nitrogen and the reaction was carried out by heating and refluxing for 5 hours. Upon completion of the reaction, excess POCl3 was removed by distillation.The residue was quenched with ice water and subsequently extracted with dichloromethane (3×). The organic phases were combined and purified by fast silica gel column chromatography using a hexane solution of 10-25% ethyl acetate as eluent to afford the target product 1-chloro-7-methylisoquinoline (3.40 g, 85% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 8.21 (d, 1H), 8.11 (s, 1H), 7.75 (d, 1H), 7.60 (d, 1H), 7.55 (d, 1H), 2.60 (s, 3H).

References

[1] Patent: US2007/225282, 2007, A1. Location in patent: Page/Page column 29

1-CHLORO-7-METHYLISOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-CHLORO-7-METHYLISOQUINOLINE Suppliers

China 45 India 1 United Kingdom 1 United States 7 Global 54

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Synthonix Inc

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Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

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Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Proactive Molecular Research

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Email: tony@proactivemr.com
Country: United States
ProdList: 895
Advantage: 0

24188-80-5, 1-CHLORO-7-METHYLISOQUINOLINERelated Search:

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1-CHLORO-7-METHYLISOQUINOLINE

1-Chlor-7-methyl-isochinolin

Isoquinoline, 1-chloro-7-methyl-

24188-80-5