ChemicalBook > CAS DataBase List > LY-404039

LY-404039

Product Name
LY-404039
CAS No.
635318-11-5
Chemical Name
LY-404039
Synonyms
CS-1104;LY2140023;LY-404039;LY-404039C;pomaglumetad;LY404039 3.03G;LY2140023/LY404039;LY 404039; LY404039;LY-404039 USP/EP/BP;LY404039 >=98% (HPLC)
CBNumber
CB92468179
Molecular Formula
C7H9NO6S
Formula Weight
235.21
MOL File
635318-11-5.mol
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LY-404039 Property

Melting point:
>250 °C(Solv: water (7732-18-5))
Boiling point:
600.3±55.0 °C(Predicted)
Density 
1.888
storage temp. 
Store at -20°C
solubility 
insoluble in DMSO; insoluble in EtOH; insoluble in H2O
form 
crystalline solid
pka
1.15±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18408
Product name
LY404039
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18408
Product name
LY404039
Purity
≥95%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
18408
Product name
LY404039
Purity
≥95%
Packaging
10mg
Price
$144
Updated
2024/03/01
Cayman Chemical
Product number
18408
Product name
LY404039
Purity
≥95%
Packaging
25mg
Price
$321
Updated
2024/03/01
Usbiological
Product number
474131
Product name
LY-404039
Packaging
100mg
Price
$2272
Updated
2021/12/16
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LY-404039 Chemical Properties,Usage,Production

Uses

LY 2140023 is a drug developed as a treatment option for schizophrenia. It targets the mGlu2/3 receptor once metabolized.

Definition

ChEBI: LY404039 is an organic heterobicyclic compound that is (1S,5R)-2-thiabicyclo[3.1.0]hexane carrying oxo, oxo, amino, carboxy, and carboxy groups at positions 2, 2, 4S, 4S, and 6S, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 mGluR3 (Ki = 149 nM and 92 nM, respectively) and exhibits antipsychotic and anxiolytic efficacy in animal models. It has a role as a metabotropic glutamate receptor agonist, an antipsychotic agent, an anxiolytic drug and a dopamine agonist. It is a dicarboxylic acid, a bridged compound, an organic heterobicyclic compound, a sulfone and a non-proteinogenic amino acid derivative.

Biological Activity

ly404039 is a potent and highly selective agonist of recombinant human mglu2 and mglu3 receptors and rat neurons expressing native mglu2/3 receptor with ki values of 149, 92 and 88 nm, respectively [1].the inhibition of forskolin-stimulated camp formation has indicated that ly404039 was a nanomolar potent agonist of human mglu2 (ec50 = 23 nm) and mglu3 (ec50 = 48 nm) receptors. additionally, ly404039 could concentration-dependently decrease excitatory postsynaptic potentials (epsps) in rat striatal spiny neuron (ec50 = 141 nm). ly404039 has also been reported to suppress the frequency of 5-ht-induced postsynaptic currents (ec50 = 82.3 nm) in rat prefrontal cortical slices [1].

References

[1] rorick-kehn lm1, johnson bg, burkey jl, wright ra, calligaro do, marek gj, nisenbaum es, catlow jt, kingston ae, giera dd, herin mf, monn ja,mckinzie dl, schoepp dd. pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1r,4s,5s,6s)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (ly404039). j pharmacol exp ther. 2007 apr;321(1):308-17. epub 2007 jan 4. j pharmacol exp ther. 2007 apr;321(1):308-17. epub 2007 jan 4.

LY-404039 Preparation Products And Raw materials

Raw materials

Preparation Products

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635318-11-5, LY-404039Related Search:


  • LY-404039
  • LY2140023
  • (1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
  • 4-Amino-2-thiabicyclo(3.1.0)hexane-4,6-dicarboxylic acid
  • LY404039 3.03G
  • LY404039CAS:635318-11-5
  • (1R,4S,5S,6S)-4-AMINO-2-THIABICYCLO 3.1.0 HEXANE-4,6-DICARBOXYLIC ACID 2,2-DIOXIDE (LY 404039)
  • (1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
  • LY2140023/LY404039
  • (1R,4S,5S)-4-aMino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
  • CS-1104
  • LY-404039C
  • LY 404039; LY404039
  • pomaglumetad
  • POMAGLUMETAD;LY2140023
  • 2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, 4-amino-, 2,2-dioxide, (1R,4S,5S,6S)-
  • LY404039 >=98% (HPLC)
  • LY-404039 USP/EP/BP
  • Pomaglumetad (LY404039)
  • 2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylicacid, 4-amino-, 2...
  • 635318-11-5
  • Inhibitors