LY-404039

ChemicalBook > CAS DataBase List > LY-404039

Product Name: LY-404039
CAS No.: 635318-11-5
Chemical Name: LY-404039
Synonyms: CS-1104;LY2140023;LY-404039;LY-404039C;pomaglumetad;LY404039 3.03G;LY2140023/LY404039;LY 404039; LY404039;LY-404039 USP/EP/BP;LY404039 >=98% (HPLC)
CBNumber: CB92468179
Molecular Formula: C7H9NO6S
Formula Weight: 235.21
MOL File: 635318-11-5.mol

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LY-404039 Property

Melting point:: >250 °C(Solv: water (7732-18-5))
Boiling point:: 600.3±55.0 °C(Predicted)
Density: 1.888
storage temp.: Store at -20°C
solubility: insoluble in DMSO; insoluble in EtOH; insoluble in H2O
form: crystalline solid
pka: 1.15±0.40(Predicted)
color: White to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18408
Product name: LY404039
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18408
Product name: LY404039
Purity: ≥95%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 18408
Product name: LY404039
Purity: ≥95%
Packaging: 10mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 18408
Product name: LY404039
Purity: ≥95%
Packaging: 25mg
Price: $321
Updated: 2024/03/01

Usbiological

Product number: 474131
Product name: LY-404039
Packaging: 100mg
Price: $2272
Updated: 2021/12/16

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LY-404039 Chemical Properties,Usage,Production

Uses

LY 2140023 is a drug developed as a treatment option for schizophrenia. It targets the mGlu2/3 receptor once metabolized.

Definition

ChEBI: LY404039 is an organic heterobicyclic compound that is (1S,5R)-2-thiabicyclo[3.1.0]hexane carrying oxo, oxo, amino, carboxy, and carboxy groups at positions 2, 2, 4S, 4S, and 6S, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 mGluR3 (Ki = 149 nM and 92 nM, respectively) and exhibits antipsychotic and anxiolytic efficacy in animal models. It has a role as a metabotropic glutamate receptor agonist, an antipsychotic agent, an anxiolytic drug and a dopamine agonist. It is a dicarboxylic acid, a bridged compound, an organic heterobicyclic compound, a sulfone and a non-proteinogenic amino acid derivative.

Biological Activity

ly404039 is a potent and highly selective agonist of recombinant human mglu2 and mglu3 receptors and rat neurons expressing native mglu2/3 receptor with ki values of 149, 92 and 88 nm, respectively [1].the inhibition of forskolin-stimulated camp formation has indicated that ly404039 was a nanomolar potent agonist of human mglu2 (ec50 = 23 nm) and mglu3 (ec50 = 48 nm) receptors. additionally, ly404039 could concentration-dependently decrease excitatory postsynaptic potentials (epsps) in rat striatal spiny neuron (ec50 = 141 nm). ly404039 has also been reported to suppress the frequency of 5-ht-induced postsynaptic currents (ec50 = 82.3 nm) in rat prefrontal cortical slices [1].

References

[1] rorick-kehn lm1, johnson bg, burkey jl, wright ra, calligaro do, marek gj, nisenbaum es, catlow jt, kingston ae, giera dd, herin mf, monn ja,mckinzie dl, schoepp dd. pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1r,4s,5s,6s)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (ly404039). j pharmacol exp ther. 2007 apr;321(1):308-17. epub 2007 jan 4. j pharmacol exp ther. 2007 apr;321(1):308-17. epub 2007 jan 4.

LY-404039 Preparation Products And Raw materials

Raw materials

Preparation Products

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635318-11-5, LY-404039Related Search:

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY3143921 LY 2606368 LY 379268 LY-2940094 LY2109761 LY 294002 HYDROCHLORIDE Pioglitazone Loperamide hydrochloride GO 6983 Olanzapine Levosulpiride GW788388

LY-404039

LY2140023

(1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide

4-Amino-2-thiabicyclo(3.1.0)hexane-4,6-dicarboxylic acid

LY404039 3.03G

LY404039CAS:635318-11-5

(1R,4S,5S,6S)-4-AMINO-2-THIABICYCLO 3.1.0 HEXANE-4,6-DICARBOXYLIC ACID 2,2-DIOXIDE (LY 404039)

(1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide

LY2140023/LY404039

(1R,4S,5S)-4-aMino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide

CS-1104

LY-404039C

LY 404039; LY404039

pomaglumetad

POMAGLUMETAD;LY2140023

2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, 4-amino-, 2,2-dioxide, (1R,4S,5S,6S)-

LY404039 >=98% (HPLC)

LY-404039 USP/EP/BP

Pomaglumetad (LY404039)

2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylicacid, 4-amino-, 2...

635318-11-5

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