ChemicalBook > CAS DataBase List > 2-chloro-5-methylpyridin-4-amine
2-chloro-5-methylpyridin-4-amine
- Product Name
- 2-chloro-5-methylpyridin-4-amine
- CAS No.
- 79055-62-2
- Chemical Name
- 2-chloro-5-methylpyridin-4-amine
- Synonyms
- 2-Chloro-5-Methyl-pyridin-4-ylaMine;Fampridine Impurity 174;2-Chloro-5-Methyl-4-pyridinaMine;2-chloro-5-methylpyridin-4-amine;2-Chloro-4-amino-5-methylpyridine;4-aMino-2-chloro-5-Methylpyridine;4-PYRIDINAMINE, 2-CHLORO-5-METHYL-;2-Chloro-5-methyl pyridine-4-amine;2-Chloro-5-methylpyridin-4-amine98%;2-Chloro-5-methylpyridin-4-amine 98%
- CBNumber
- CB92468371
- Molecular Formula
- C6H7ClN2
- Formula Weight
- 142.59
- MOL File
- 79055-62-2.mol
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2-chloro-5-methylpyridin-4-amine Property
- Melting point:
- 115℃
- Boiling point:
- 310.1±37.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder
- pka
- 5.11±0.42(Predicted)
- color
- Off-white
- InChI
- InChI=1S/C6H7ClN2/c1-4-3-9-6(7)2-5(4)8/h2-3H,1H3,(H2,8,9)
- InChIKey
- CJGKOPNIXJWHKF-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C)C(N)=C1
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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N-Bromosuccinimide Price
TRC
- Product number
- C350020
- Product name
- 2-Chloro-5-methyl-pyridin-4-ylamine
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W021662
- Product name
- 2-Chloro-5-methylpyridin-4-amine
- Purity
- 99.76%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR305585
- Product name
- 2-Chloro-5-methylpyridin-4-amine
- Purity
- 98%
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-5-BF
- Product name
- 2-Chloro-5-methylpyridin-4-amine
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA76127
- Product name
- 4-Amino-2-chloro-5-methylpyridine
- Packaging
- 2g
- Price
- $40
- Updated
- 2021/12/16
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2-chloro-5-methylpyridin-4-amine Chemical Properties,Usage,Production
Synthesis
2-chloro-5-methylpyridin-4-amine was synthesised by reaction with 2-chloro-5-methyl-4-nitropyridine 1-oxide. The synthesis steps are as follows:
A glass pressure reactor with cross-beam stirrer was charged under argon with 29 g (153.788 mmol) of 2-chloro-5-methyl-4-nitro-1-oxidopyridin-1-ium and 2.9 g of hydrogenation catalyst (0.8% Pt and 0.6% Mo on activated carbon (D505A-105 0.8% Pt+0.6% Mo on carbon powder, BASF) and 320 ml of ethanol were added. The reactor was closed and inertized three times, each time with 3 bar argon overpressure. Hydrogenation was then carried out for 20 hours at 30℃, under a 3 bar hydrogen overpressure (conversion >98%). The reactor was inertized with argon and the reaction solution filtered through 10 g of kieselguhr. The filtrate was concentrated to dryness under reduced pressure. Yield: 23.0 g (quantitative, product still contained ethanol), purity: 97.5% (HPLC) (0051) MS (EIpos): m/z=143 [M+H]+ (0052) 1H-NMR (300 MHz, DMSO-d6): δ=1.96 (s, 3H), 6.16 (br s, 2H), 6.50 (s, 1H), 7.68 (s, 1H) In an analogous manner, a conversion of approx. 98% was achieved with a catalyst consisting of 0.8% Pt and 0.3% Mo on activated carbon. Use of 1% Pt+2% V on activated carbon achieved a conversion of approx. 87%.
References
[1] Patent: CN103193704, 2016, B. Location in patent: Paragraph 0025; 0035-0039
[2] Patent: WO2005/100342, 2005, A1. Location in patent: Page/Page column 24; 39
[3] Patent: WO2003/91246, 2003, A1. Location in patent: Page/Page column 49
2-chloro-5-methylpyridin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-chloro-5-methylpyridin-4-amine manufacturers
Shanghai Joiny Pharmaceutical Co.,LTD
- Product
- 4-Amino-2-chloro-5-methylpyridine 79055-62-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-09-19
Wuhan Biocar Pharmacy CO.,Ltd.
- Product
- 2-chloro-5-methylpyridin-4-amine 79055-62-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 6000kg
- Release date
- 2025-03-11
Henan Aochuang Chemical Co.,Ltd.
- Product
- 4-PYRIDINAMINE, 2-CHLORO-5-METHYL 79055-62-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
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