Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Product Name
- Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- CAS No.
- 27143-07-3
- Chemical Name
- Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Synonyms
- Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate;(Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester;Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Apixaban-2;hydrazono);Ethyl chloro;RSYY（Avanafil)-38;RSYY（Avanafil)-43
- CBNumber
- CB92500866
- Molecular Formula
- C11H13ClN2O3
- Formula Weight
- 256.69
- MOL File
- 27143-07-3.mol
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Property
- Melting point:
- 94℃
- Boiling point:
- 349.0±44.0 °C(Predicted)
- Density
- 1.23
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- 11.63±0.10(Predicted)
- color
- Yellow to Dark Yellow
- InChI
- InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3
- InChIKey
- ATNPZEGMKLGIFA-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C(Cl)=NNC1=CC=C(OC)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- Z346018
- Product name
- Ethyl2-Chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- AK-94053
- Product name
- Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Purity
- 97%
- Packaging
- 10g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- J96727
- Product name
- (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Packaging
- 10g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 058646
- Product name
- Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- 058646
- Product name
- Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate
- Purity
- >95%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Chemical Properties,Usage,Production
Physical properties
Light yellow to dark yellow solid
Uses
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.
Synthesis
Step-1:Water (600 ml) was added to p-anisidine (100 g) at room temperature and the resulting mixture was cooled to 10°C, followed by the addition of concentrated hydrochloric acid (133.5 g). The resulting mixture was cooled to —5°C to 0°C, followed by portion-wise addition of 40 % aqueous sodium nitrite solution over 45 minutes to 1 hour. The resulting mass was stirred for 1 hour 30 minutes at —5°C to0°C, followed by slow addition of 11 % sulfamic acid solution over 1 hour to 1 hour 30 minutes to produce a reaction mass (first part).Step-2:Sodium acetate (146 g) was added to water (300 ml) at room temperature and then stirred for 10 minutes to 15 minutes, followed by the addition of ethyl 2-chloroacetoacetate (160.4g) and acetone (300 ml) at room temperature to form a reaction mixture. The resulting mixture was cooled to 0°C. The resulting mixture was added to the reaction mass (first part) obtained in step-i at —5°C to 0°C and then stirred for 1 hour at the same temperature. Acetone (200 ml) was added to the resulting mass and stirred for 30 minutes at —5°C to 0°C. The resulting mass was settled for 5 hours at —5°C to 0°Cand then filtered the solid. Methanol (150 ml) was added to the resulting solid at room temperature and then stirred for 2 hours at the same temperature. Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazone)acetate was obtained through further purity.
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Suppliers
- Tel
- Country
- China Hong Kong
- ProdList
- 878
- Advantage
- 55
View Lastest Price from Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate manufacturers
- Product
- Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 27143-07-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1200KG/M
- Release date
- 2023-08-17
- Product
- Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate 27143-07-3
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-24
- Product
- Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 27143-07-3
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-05-17