YM155

Product Name: YM155
CAS No.: 781661-94-7
Chemical Name: YM155
Synonyms: M155;YM155;CS-35;Sepantronium;YM155, >=98%;YM-155;YM 155;YM155 USP/EP/BP;SepantroniuM broMide;Survivin Inhibitor YM155;YM-155, survivin inhibitor
CBNumber: CB92506237
Molecular Formula: C20H19BrN4O3
Formula Weight: 443.29386
MOL File: 781661-94-7.mol

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YM155 Property

Melting point:: >180°C (dec.)
storage temp.: -20°
solubility: Soluble in DMSO (up to 25 mg/ml).
form: solid
color: Tan to yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 574662
Product name: Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem
Purity: The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin.
Packaging: 10MG
Price: $155
Updated: 2022/05/15

Cayman Chemical

Product number: 11490
Product name: YM-155
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 11490
Product name: YM-155
Purity: ≥98%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 11490
Product name: YM-155
Purity: ≥98%
Packaging: 10mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 11490
Product name: YM-155
Purity: ≥98%
Packaging: 25mg
Price: $257
Updated: 2024/03/01

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YM155 Chemical Properties,Usage,Production

Description

YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1?Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2?Induces DNA damage.3?YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4

Uses

YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.

Uses

YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC. cell lines. Potent Survivin Inhibitor.

Definition

ChEBI: Sepantronium bromide is an organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis. It has a role as an antineoplastic agent, a survivin suppressant and an apoptosis inducer. It contains a sepantronium.

target

Survivin

storage

Store at -20°C

References

1) Nakahara?et al. (2007),?YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res.?67?8014 2) Okamoto?et al. (2012),?Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther.?11?204 3) Glaros?et al. (2012),?The ‘survivin suppressants’ NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother. Pharmacol.?70?207 4) Wang?et al. (2014),?Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis?19?748

YM155 Preparation Products And Raw materials

Raw materials

Preparation Products

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YM155 Suppliers

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View Lastest Price from YM155 manufacturers

Career Henan Chemical Co

Product: YM155 781661-94-7
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-12

781661-94-7, YM155Related Search:

Rapamycin 6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE Avobenzone 4-Methoxyphenol YM 26734 1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride BTP2 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate YM-53601 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide YM17E Bortezomib Alisertib (MLN8237) Vorinostat Trametinib ABT 263 CHIR-99021

YM155

4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide

SepantroniuM broMide

SepantroniuM broMide(YM155,YM-155)

Sepantronium Bromide (YM155)

1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1)

4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide YM 155

YM 155 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide

Sepantronium

YM155 (SepantroniuM BroMide)

YM-155;YM 155

CS-35

3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide

1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione

3-(2-Methoxy-ethyl)-2-methyl-4,9-dioxo-1-pyrazin-2-ylmethyl-2,3,4,9-tetrahydro-1H-naphtho[2,3-d]imidazol-1-ium

YM155, >=98%

1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide

YM155 (SEPANTRONIUM BROMIDE);YM-155

4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidaz

YM155, 98%, a novel small molecule survivin suppressant

3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(pyrazin-2-ylmethyl)naphtho[2,3-d]imidazol-1-ium bromide

YM155 USP/EP/BP

1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione,bromide

M155

Survivin Inhibitor YM155

1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide

YM-155, survivin inhibitor

Sepantronium bromide, 10 mM in DMSO

781661-94-7

C20H19N4O3Br

Inhibitors

Antineoplastic

apis

Inhibitor