3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

ChemicalBook > CAS DataBase List > 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

Product Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
CAS No.: 1164470-53-4
Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Synonyms: 003;Sal 003;CS-1897;(2E)-3-Phenyl-N-(2;SAL-003;SAL 003;SAL003;eIF-2α Inhibitor II, Sal003;Sal-003,Sal 003,Apoptosis,Inhibitor,Sal003,inhibit,Phosphatase;2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide;(E)-N-(2,2,2-Trichloro-1-(3-(4-chlorophenyl)thioureido)ethyl)cinnamamide;3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
CBNumber: CB92518799
Molecular Formula: C18H15Cl4N3OS
Formula Weight: 463.21
MOL File: 1164470-53-4.mol

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3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Property

storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
form: powder
color: white to off-white

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4451
Product name: Sal003
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: S4451
Product name: Sal003
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $595
Updated: 2024/03/01

Cayman Chemical

Product number: 23414
Product name: Sal-003
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 23414
Product name: Sal-003
Purity: ≥98%
Packaging: 10mg
Price: $155
Updated: 2024/03/01

Tocris

Product number: 3657
Product name: Sal003
Purity: ≥99%(HPLC)
Packaging: 10
Price: $182
Updated: 2021/12/16

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3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Chemical Properties,Usage,Production

Uses

Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.

Biological Activity

eukaryotic initiation factor 2 α-subunit (eif2α) plays a critical role in the regulation of protein synthesis. moreover, it also plays an important role in synaptic plasticity and long-term memory consolidation. sal003 is a selective inhibitor of eif2α dephosphorylation.

Biochem/physiol Actions

Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.

in vitro

sal003 specifically prevents dephosphorylation of eif2α by blocking eif2α phosphatases. in sal003-treated cells polysomes dissociated and consistent with this β-actin mrna shifted to lighter fractions, reflecting the inhibition of general translation [1].

in vivo

intra-basolateral amygdala (bla) infusions of sal003 immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced cpp, leading to a long-lasting suppression of drug-paired stimulus-induced craving. moreover, inhibition of eif2α dephosphorylation in the bla immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. these results demonstrate that eif2α dephosphorylation in the bla mediates the memory reconsolidation of drug-paired stimuli [1].

storage

Store at -20°C

References

[1] jian m, luo yx, xue yx, han y, shi hs, liu jf, yan w, wu p, meng sq, deng jh, shen hw, shi j, lu l. eif2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. j neurosci. 2014;34(30):10010-21.

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide manufacturers

Career Henan Chemical Co

Product: 1164470-53-4 1164470-53-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kgs
Release date: 2019-12-17

1164470-53-4, 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamideRelated Search:

WP1066 WP1130 (2E)-3-(4'-Hydroxy-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl)-2-propenoic acid Pracinostat BAY 11-7085 ML264 (-)-Blebbistatin Bortezomib BX-795 MG-132 Debio-1347 Rapamycin

SAL-003;SAL 003;SAL003

CS-1897

(2E)-3-Phenyl-N-(2

2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide

SAL003;(2E)-3-PHENYL-N-(2;2;2-TRICHLORO-1-{[(4-CHLOROPHENYL)CARBAMOTHIOYL]AMINO}ETHYL)ACRYLAMIDE

eIF-2α Inhibitor II, Sal003

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

Sal 003

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide SAL003

003

2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-, (2E)-

(E)-N-(2,2,2-Trichloro-1-(3-(4-chlorophenyl)thioureido)ethyl)cinnamamide

Sal-003,Sal 003,Apoptosis,Inhibitor,Sal003,inhibit,Phosphatase

1164470-53-4

Inhibitors