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Voreloxin

Product Name
Voreloxin
CAS No.
175414-77-4
Chemical Name
Voreloxin
Synonyms
SPC-595;SNS-595;AG-7352;CS-1489;VOSAROXIN;Voreloxin;Voreloxin, >=98%;Voreloxin (SNS-595);Voreloxin USP/EP/BP;SNS-595; VOSAROXIN; AG 7352
CBNumber
CB92538816
Molecular Formula
C18H19N5O4S
Formula Weight
401.44
MOL File
175414-77-4.mol
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Voreloxin Property

Boiling point:
652.0±65.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; insoluble in DMSO
form 
solid
pka
5.68±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
V759000
Product name
Voreloxin
Packaging
2.5mg
Price
$165
Updated
2021/12/16
TRC
Product number
V759000
Product name
Voreloxin
Packaging
25mg
Price
$965
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181346
Product name
Voreloxin
Purity
>98%
Packaging
100mg
Price
$1133.9
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
42621
Product name
Voreloxin
Packaging
25mg
Price
$1375
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181346
Product name
Voreloxin
Purity
>98%
Packaging
250mg
Price
$1949.9
Updated
2021/12/16
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Voreloxin Chemical Properties,Usage,Production

Uses

Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity.

Biological Activity

voreloxin, formerly known as sns-595 or ag-7352, is a novel naphthyridine analog, which is structurally related to the quinolone antibiotics, a chemical class not previously used for the treatmentof cancer.

in vitro

in vitro studies demonstrated voreloxin has broad anti-proliferative activity in 11 tumor cell lines, with ic50 values ranging from 0.04 to 0.97 μm. similar activity was observed in vitro in drug-resistant cell lines, including those that overexpress p-glycoprotein [2].

in vivo

after a single intravenous dose, voreloxin concentrations in tumor were correlated with induction of the apoptosis marker caspase-3. administration of voreloxin at 20 mg/kg weekly inhibited tumor growth (86%). voreloxin demonstrated strong dose-dependent tumor growth inhibition (63–88%) in 10 of 11 solid tumor xenograft models [2].

References

[1] tsuzuki y, tomita k, shibamori k, sato y, kashimoto s, chiba k. synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. part 2. j med chem. 2004;47(8):2097-109.
[2] hoch u, lynch j, sato y, kashimoto s, kajikawa f, furutani y, silverman ja. voreloxin, formerly sns-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models. cancer chemother pharmacol. 2009;64(1):53-65.
[3] advani rh, hurwitz hi, gordon ms, ebbinghaus sw, mendelson ds, wakelee ha, hoch u, silverman ja, havrilla na, berman cj, fox ja, allen rs, adelman dc. voreloxin, a first-in-class anticancer quinolone derivative, in relapsed/refractory solid tumors: a report on two dosing schedules. clin cancer res. 2010;16(7):2167-75.

Voreloxin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Voreloxin manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Voreloxin 175414-77-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Voreloxin 175414-77-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
Voreloxin 175414-77-4
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

175414-77-4, VoreloxinRelated Search:


  • 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo -1-(2-thiazolyl)-
  • Voreloxin (SNS-595)
  • Voreloxin, >=98%
  • Voreloxin
  • AG-7352
  • SNS-595
  • SPC-595
  • AG-7352, 1,4-dihydro-7-[(S,S)-3-Methoxy-4-MethylaMino-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic, (+)-1,4-dihydro-7-[(3S,4S)-3-Methoxy-4-(MethylaMino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
  • VOSAROXIN
  • 7-((3S,4S)-3-Methoxy-4-(MethylaMino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
  • 7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid
  • SNS-595; VOSAROXIN; AG 7352
  • CS-1489
  • 1,4-Dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
  • Voreloxin USP/EP/BP
  • 175414-77-4
  • API
  • Inhibitors