OMecaMtiv Mecarbil

Description In vitro In vivo

Product Name: OMecaMtiv Mecarbil
CAS No.: 873697-71-3
Chemical Name: OMecaMtiv Mecarbil
Synonyms: CS-827;CK1827452;CK-1827452;CK 1827452O;CK1827452, >98%;mecamtiv mecarbil;OMecaMtiv Mecarbil;Omecamtiv mecarbil?, >98%;OMecaMtiv Mecarbil USP/EP/BP;CK-1827452 (OMecaMtiv Mecarbil)
CBNumber: CB92561487
Molecular Formula: C20H24FN5O3
Formula Weight: 401.43
MOL File: 873697-71-3.mol

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OMecaMtiv Mecarbil Property

Melting point:: 180℃
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Water Solubility: 40.25mg/L at 25℃
LogP: -0.531

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21074
Product name: CK-1827452
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21074
Product name: CK-1827452
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 21074
Product name: CK-1827452
Purity: ≥98%
Packaging: 10mg
Price: $301
Updated: 2024/03/01

Cayman Chemical

Product number: 21074
Product name: CK-1827452
Purity: ≥98%
Packaging: 25mg
Price: $661
Updated: 2024/03/01

TRC

Product number: C544000
Product name: CK1827452
Packaging: 50mg
Price: $820
Updated: 2021/12/16

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OMecaMtiv Mecarbil Chemical Properties,Usage,Production

Description

Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.

In vitro

In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway. [

In vivo

Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.

Uses

CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.

Definition

ChEBI: Omecamtiv mecarbil is a member of ureas.

Biological Activity

omecamtiv mecarbil (ck-1827452) is the first potent cardiac myosin activator that can specifically activate the cardiac myosin s1 domain but not other muscle myosins. in

target

ATPase

References

1. malik fi1, hartman jj, elias ka, morgan bp, rodriguez h, brejc k, anderson rl, sueoka sh, lee kh, finer jt, sakowicz r, baliga r, cox dr, garard m,godinez g, kawas r, kraynack e, lenzi d, lu pp, muci a, niu c, qian x, pierce dw, pokrovskii m, suehiro i, sylvester s, tochimoto t, valdez c, wang w,katori t, kass da, shen yt, vatner sf, morgans dj. cardiac myosin activation: a potential therapeutic approach for systolic heart failure. science. 2011 mar 18;331(6023):1439-43.

OMecaMtiv Mecarbil Preparation Products And Raw materials

Raw materials

Preparation Products

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OMecaMtiv Mecarbil Suppliers

Canada 1 China 129 India 1 United Kingdom 1 United States 18 Global 150

MedChemexpress LLC

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View Lastest Price from OMecaMtiv Mecarbil manufacturers

Shenzhen Excellent Biotech Co., Ltd.

Product: Omecamtiv Mecarbil 873697-71-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg
Release date: 2020-08-20

Career Henan Chemical Co

Product: OMecaMtiv Mecarbil 873697-71-3
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

873697-71-3, OMecaMtiv MecarbilRelated Search:

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1-Piperazinecarboxylic acid,4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-, methyl ester

OMecaMtiv Mecarbil

OMecaMtiv Mecarbil (CK-1827452)

CK1827452

CK-1827452

CK-1827452 (OMecaMtiv Mecarbil)

CK 1827452O

mecamtiv mecarbil

Methyl 4-[[2-fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate

methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate

Methyl 4-[[2-fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate Omecamtiv mecarbil(CK1827452)

methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl] piperazine-1-carboxylate

OMECAMTIV MECARBIL (CK-1827452);CK1827452

CK 1827452 - Omecamtiv Mecarbil | CK-452

CK-1827452; CK1827452;CK 1827452

CS-827

CK1827452, >98%

Omecamtiv mecarbil?, >98%

OMecaMtiv Mecarbil USP/EP/BP

1-Piperazinecarboxylic acid,4-[[2-fluoro-3-[[[(6-methyl-3-py...

873697-71-3

C20H24FN5O3

Inhibitors