IMMunoglobulin G2
- Product Name
- IMMunoglobulin G2
- CAS No.
- 1129435-60-4
- Chemical Name
- IMMunoglobulin G2
- Synonyms
- Gevokizumab;IMMunoglobulin G2;Gevokizumab (anti-IL-1b);Research Grade Gevokizumab;Research Grade Gevokizumab(DHB95602)
- CBNumber
- CB92563209
- Formula Weight
- 0
- MOL File
- Mol file
IMMunoglobulin G2 Property
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- 140771
- Product name
- Immunoglobulin G2
- Packaging
- 200ul
- Price
- $436
- Updated
- 2021/12/16
IMMunoglobulin G2 Chemical Properties,Usage,Production
Uses
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II)[1][2].
in vivo
Gevokizumab (1 mg/kg; i.v.; once daily for 3 d) improves endothelial regrowth and reduces neointima formation in rats following carotid denudation[2].
| Animal Model: | Rat carotid denudation model in Sprague-Dawley rats (3-month0-old, 330-360 g)[2] |
| Dosage: | 1, 10 and 50 mg/kg |
| Administration: | Intravenous injection; once daily for 3 days |
| Result: | Decreased carotid intima-media thickness (IMT) in the proximal part of the denuded artery at day 28, and improved endothelial regrowth at 1 mg/kg.? |
References
[1] Issafras H, et al. Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties. J Pharmacol Exp Ther. 2014 Jan;348(1):202-15. DOI:10.1124/jpet.113.205443
[2] Roubille F, et al. The interleukin-1β modulator gevokizumab reduces neointimal proliferation and improves reendothelialization in a rat carotid denudation model. Atherosclerosis. 2014 Oct;236(2):277-85. DOI:10.1016/j.atherosclerosis.2014.07.012
IMMunoglobulin G2 Preparation Products And Raw materials
Raw materials
Preparation Products
IMMunoglobulin G2 Suppliers
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58