Methyl 5-aMino-6-broMopicolinate
- Product Name
- Methyl 5-aMino-6-broMopicolinate
- CAS No.
- 797060-52-7
- Chemical Name
- Methyl 5-aMino-6-broMopicolinate
- Synonyms
- Methyl 5-aMino-6-broMopicolinate;Methyl 5-amino-6-bromo-2-pyridinecarboxylate;methyl 5-amino-6-bromopyridine-2-carboxylate;5-Amino-6-bromo-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 5-amino-6-bromo-, methyl ester
- CBNumber
- CB92617610
- Molecular Formula
- C7H7BrN2O2
- Formula Weight
- 231.05
- MOL File
- 797060-52-7.mol
Methyl 5-aMino-6-broMopicolinate Property
- Boiling point:
- 390.1±37.0 °C(Predicted)
- Density
- 1.662±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.09±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5643DW
- Product name
- Methyl5-amino-6-bromopicolinate
- Packaging
- 1g
- Price
- $660
- Updated
- 2021/12/16
- Product number
- 5643DW
- Product name
- Methyl5-amino-6-bromopicolinate
- Packaging
- 100mg
- Price
- $223
- Updated
- 2021/12/16
- Product number
- CM255088
- Product name
- Methyl5-amino-6-bromopicolinate
- Purity
- 97%
- Packaging
- 1g
- Price
- $393
- Updated
- 2021/12/16
- Product number
- CD11055345
- Product name
- Methyl5-amino-6-bromopicolinate
- Purity
- 97%
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
- Product number
- 797060527
- Product name
- Methyl5-amino-6-bromopicolinate
- Packaging
- 250mg
- Price
- $1068.2
- Updated
- 2021/12/16
Methyl 5-aMino-6-broMopicolinate Chemical Properties,Usage,Production
Synthesis
67515-76-8
797060-52-7
General procedure for the synthesis of methyl 5-amino-6-bromopyridine-2-carboxylate from methyl 5-aminopyridine-2-carboxylate: 2.0 mL of hydrogen peroxide solution (32% concentration) was slowly added to a mixed solution containing methyl 5-aminopyridine-2-carboxylate (2.0 g, 13.15 mmol) and 30 mL of 48% concentration hydrobromic acid. The reaction mixture was stirred at room temperature for 2 hours. Subsequently, an additional 0.32 mL of hydrogen peroxide solution was added and stirring was continued for 1 hour. Upon completion of the reaction, the mixture was cooled by an ice bath and the pH of the mixture was adjusted slowly by adding concentrated ammonia to 8. The mixture was extracted three times with ethyl acetate (60 mL each time) and the organic phases were combined. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated on a rotary evaporator. The crude product was purified by silica gel column chromatography (mobile phase: cyclohexane/ethyl acetate). 1.32 g of the target compound was finally obtained in 42.3% yield. The product was analyzed by HPLC-MS: log P = 0.96; mass (m/z): 231.0. 1H NMR (D6-DMSO) data: δ 3.79 (s, 3H), 6.40 (broad peak, 2H), 7.1 (d, 1H), 7.8 (d, 1H).
References
[1] Patent: US2015/216175, 2015, A1. Location in patent: Paragraph 0424
[2] Patent: EP1479680, 2004, A1. Location in patent: Page 49
Methyl 5-aMino-6-broMopicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 5-aMino-6-broMopicolinate manufacturers
- Product
- Methyl 5-amino-6-bromo-2-pyridinecarboxylate 797060-52-7
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-25