XL413 (BMS-863233)

ChemicalBook > CAS DataBase List > XL413 (BMS-863233)

Product Name: XL413 (BMS-863233)
CAS No.: 1169562-71-3
Chemical Name: XL413 (BMS-863233)
Synonyms: CS-1062;XL413.HCL;BMS-863233 HCl;XL413(BMS-863233);BMS-863233 (XL-413);BMS-863233 HCl salt;XL413 (hydrochloride);XL413 (BMS-863233) HCl;BMS-863233 HCl (XL-413);BMS-863233 Hydrochloride
CBNumber: CB92627547
Molecular Formula: C14H13Cl2N3O2
Formula Weight: 326.18
MOL File: 1169562-71-3.mol

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XL413 (BMS-863233) Property

storage temp.: -20°C
solubility: DMSO: Insoluble;Ethanol: Insoluble
form: powder
color: white to beige
Water Solubility: Water: 46 mg/mL (141.03 mM)
Stability:: Hygroscopic

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1401
Product name: XL413 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $201
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1401
Product name: XL413 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $663
Updated: 2024/03/01

Tocris

Product number: 5493
Product name: XL413 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $952
Updated: 2021/12/16

Tocris

Product number: 5493
Product name: XL413 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

TRC

Product number: X746230
Product name: XL413
Packaging: 5mg
Price: $135
Updated: 2021/12/16

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XL413 (BMS-863233) Chemical Properties,Usage,Production

Uses

XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor.

Biological Activity

XL413 hydrochloride is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, its selectivity over CK2, Pim-1 and pMCM2 are 63-, 12- and 35-fold. Phase 1/2.

in vitro

In MDA-MB-231T and Colo-205 cell lines,XL413 hydrochloride inhibits CDC7-specific phosphorylation of MCM2. XL413 also inhibited cell proliferation in Colo-205 cells, decreased cell viability, and stimulated caspase 3/7 activity. Furthermore, XL413 resulted in altered S-phase progression and subsequent apoptosis.

in vivo

In the Colo-205 xenograft model, XL413, at a dose of 3 mg/kg, inhibited 70% of phosphorylated MCM2 and caused significant regression of tumor growth at a dose of 100 mg/kg.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> CK2
(Cell-free assay)

Target	Value
Cdc7 (Cell-free assay)	3.4 nM
Pim1 (Cell-free assay)	42 nM
212 nM

storage

Store at -20°C

XL413 (BMS-863233) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from XL413 (BMS-863233) manufacturers

Career Henan Chemical Co

Product: XL413 (BMS-863233) 1169562-71-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

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8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride

CS-1062

XL 413 hydrochloride - BMS 863233 hydrochloride

BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413.

Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-, (Hydrochloride) (1:)

XL413 (hydrochloride)

BMS-863233 (XL-413)

8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride (1:?)

XL413(BMS-863233)

BMS-863233 HCl

Benzofuro[3,2-d]pyrimidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-, hydrochloride

BMS-863233 HCl salt

XL413.HCL

BMS-863233 HCl (XL-413)

(4AR,6S,7R,7AS)-6-[4-[[(1S)-2,3-DIHYDRO-1H-INDEN-1-YL]AMINO]PYRROLO[2,3-D]PYRIMIDIN-7-YL]-2-(4-METHOXYPHENYL)-4,4A,5,6,7,7A-HEXAHYDROCYCLOPENTA[D][1,3]DIOXIN-7-OL

BMS-863233 Hydrochloride

XL413 (BMS-863233) USP/EP/BP

XL413 (BMS-863233) HCl

(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one xhydrochloride

1169562-71-3

C14H12ClN3O2xHCl

Inhibitors

API