1,11b-Dihydro-11b-hydroxyMedicarpin
- Product Name
- 1,11b-Dihydro-11b-hydroxyMedicarpin
- CAS No.
- 210537-04-5
- Chemical Name
- 1,11b-Dihydro-11b-hydroxyMedicarpin
- Synonyms
- 1,11B-DIHYDRO-11B-HYDROXYMEDICAR;1,11b-Dihydro-11b-hydroxyMedicarpin;11b-Hydroxy-11b1-dihydromedicarpin/111b-Dihydro-11b-hydroxymedicarpin;(6aR,11aR,11bS)-1,2,6,6a,11a,11b-Hexahydro-11b-hydroxy-9-methoxy-3H-benzofuro[3,2-c][1]benzopyran-3-one;3H-Benzofuro[3,2-c][1]benzopyran-3-one, 1,2,6,6a,11a,11b-hexahydro-11b-hydroxy-9-methoxy-, (6aR,11aR,11bS)-
- CBNumber
- CB92630046
- Molecular Formula
- C16H16O5
- Formula Weight
- 288.3
- MOL File
- 210537-04-5.mol
1,11b-Dihydro-11b-hydroxyMedicarpin Property
- Boiling point:
- 490.0±45.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 13.53±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- CFN96002
- Product name
- 1,11b-Dihydro-11b-hydroxymedicarpin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $553
- Updated
- 2021/12/16
- Product number
- CD32002004
- Product name
- 1,11b-Dihydro-11b-hydroxymedicarpin
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $860
- Updated
- 2021/12/16
1,11b-Dihydro-11b-hydroxyMedicarpin Chemical Properties,Usage,Production
Uses
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
References
[1] Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190.
[2] Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541. DOI:10.1371/journal.pone.0144541
[3] Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299. DOI:10.1016/j.intimp.2020.106299
1,11b-Dihydro-11b-hydroxyMedicarpin Preparation Products And Raw materials
Raw materials
Preparation Products
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