N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Appearance Uses

Product Name: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine
CAS No.: 1289942-66-0
Chemical Name: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine
Synonyms: EZ-M1;EZLA-M1;Enzalutamide ITS-2;Enzalutamide Impurity N2;N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl];N-[3-fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methyl-;N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine;2-[3-fluoro-4-(methylcarbamoyl)anilino]-2-methyl-propanoicaci;2-[3-fluoro-4-(methylcarbamoyl)anilino]-2-methyl-propanoic acid;5. N-[3-Fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methylalanine
CBNumber: CB92657793
Molecular Formula: C12H15FN2O3
Formula Weight: 254.26
MOL File: 1289942-66-0.mol

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N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Property

Boiling point:: 455℃
Density: 1.286
Flash point:: 229℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.59±0.10(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C12H15FN2O3/c1-12(2,11(17)18)15-7-4-5-8(9(13)6-7)10(16)14-3/h4-6,15H,1-3H3,(H,14,16)(H,17,18)
InChIKey: IAAHEGARPMZSTJ-UHFFFAOYSA-N
SMILES: C(O)(=O)[C@](C)(C)NC1=CC=C(C(NC)=O)C(F)=C1

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Safety

HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F599803
Product name: 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoicacid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F599803
Product name: 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoicacid
Packaging: 50mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 3076AH
Product name: 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoicacid
Packaging: 1g
Price: $40
Updated: 2021/12/16

Activate Scientific

Product number: AS46673
Product name: 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid
Purity: 97+%
Packaging: 1g
Price: $68
Updated: 2021/12/16

ChemScene

Product number: CS-M2260
Product name: Alanine,N-[3-fluoro-4-[(methylamino)carbonyl]phenyl]-2-methyl-
Packaging: 10g
Price: $83
Updated: 2021/12/16

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N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Chemical Properties,Usage,Production

Appearance

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine is a white to off-white solid.

Uses

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine is an amino acid derivative and can be used as an intermediate in pharmaceutical synthesis.

Uses

2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid is an alanine derivative[1].

Synthesis

749927-69-3

62-57-7

1289942-66-0

The general procedure for the synthesis of 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid from 4-bromo-2-fluoro-N-methylbenzamide and 2-aminoisobutyric acid was as follows: 4-bromo-2-fluoro-N-methylbenzamide (10 g, 43.1 mmol), 2-aminoisobutyric acid (6.7 g, 64.7 mmol), potassium carbonate ( 23.8 g, 172.4 mmol) and proline (0.7 g, 4.31 mmol) were added sequentially to a single-neck flask. Subsequently, water (1.8 ml, 100 mmol) was dissolved in DMF (60 ml) and this solution was added to the flask. Under nitrogen protection, CuCl (0.45 g, 4.31 mmol) was added to the reaction mixture, and then the reaction system was heated to 100 °C and the reaction was continuously stirred for 24 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted with dichloromethane. After separation of the organic phase, the pH of the aqueous phase was adjusted to 4 with 1 mol/L citric acid solution, at which point a solid precipitated. The solid was collected by filtration and washed three times with a mixture of water and ethanol (100:1, v/v), resulting in 9.5 g of pure white solid product in 87% yield.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1111. DOI:10.1080/10408398.2012.708368

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Suppliers

China 230 India 8 United States 4 Global 242

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View Lastest Price from N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine 1289942-66-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-19

Henan Fengda Chemical Co., Ltd

Product: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine 1289942-66-0
Price: US $10.00-3.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-29

Hebei Miaobian Biotechnology Co., Ltd

Product: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine 1289942-66-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.99
Supply Ability: 10Ton
Release date: 2021-12-07

1289942-66-0, N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanineRelated Search:

N-Acetyl-L-cysteine N-CARBAMYL-L-GLUTAMIC ACID EnzalutaMide IMpurity methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate 4-Bromo-2-fluorobenzoic acid 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide Enzalutamide Methyl 4-bromo-2-fluorobenzoate 4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE Enzalutamide carboxylic acid N-desMethyl EnzalutaMide [2H6]-Enzalutamide Enzalutamide Impurity 7 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 7 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- 4-amino-2-fluoro-N-methylbenzamide

Alanine, N-[3-fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methyl-

5. N-[3-Fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methylalanine

N-[3-Fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methylalanine(for EnzalutaMide)

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

2-[3-fluoro-4-(methylcarbamoyl)anilino]-2-methyl-propanoic acid

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine ISO 9001：2015 REACH

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]

Enzalutamide ITS-2

EZ-M1

2-[3-fluoro-4-(methylcarbamoyl)anilino]-2-methyl-propanoicaci

N-[3-Fluoro-4-[(MethylaMino)carbonyl]phenyChemicalbookl]-2-Methylalanine(forEnzalutaMide)

N-[3-fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methyl-

EZLA-M1

Enzalutamide Impurity N2

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine (Intermediate of Enzalutamide)

1289942-66-0