GS9620
- Product Name
- GS9620
- CAS No.
- 1228585-88-3
- Chemical Name
- GS9620
- Synonyms
- Gs-20;CS-925;GS9620;GS-9620;GS 9620;Vesatolimod;GS9620, >=98%;GS 9620; GS9620;GS-9620(Vesatolimod);Vesatolimod GS-9620
- CBNumber
- CB92666623
- Molecular Formula
- C22H30N6O2
- Formula Weight
- 410.51
- MOL File
- 1228585-88-3.mol
GS9620 Property
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (10 mg/ml)
- form
- solid
- pka
- 10.34±0.20(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19628
- Product name
- GS-9620
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 19628
- Product name
- GS-9620
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 19628
- Product name
- GS-9620
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $180
- Updated
- 2024/03/01
- Product number
- 19628
- Product name
- GS-9620
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- A3444
- Product name
- GS-9620
- Packaging
- 50mg
- Price
- $700
- Updated
- 2021/12/16
GS9620 Chemical Properties,Usage,Production
Description
GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic infection and transiently activated HIV expressionex vivoin latently-infected peripheral blood mononuclear cells (PBMCs) from virally suppressed patients. Currently, GS-9620 is under clinical evaluation for treating chronic HBV infection and for reducing latent reservoirs in virally-suppressed HIV-infected patients.
target
TLR-7
References
Lopatin, U, et al. "Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist." Antiviral Therapy18.3(2013):409-18.
Gane, E. J., et al. "The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection." Journal of Hepatology63.2(2015):320.
Lanford, Robert E., et al. "GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees." Gastroenterology 144.7(2013):1508.
GS9620 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GS9620 manufacturers
- Product
- GS9620 1228585-88-3
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-09-07
- Product
- GS9620 1228585-88-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-08-07