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TOFOGLIFLOZIN

Product Name
TOFOGLIFLOZIN
CAS No.
1201913-82-7
Chemical Name
TOFOGLIFLOZIN
Synonyms
Tofogliflozin Monohydrate;CSG452; CSG-452; TOFOGLIFLOZIN; CSG 452; UNII-554245W62TTOFOGLIFLOZIN [INN]; TOFOGLIFLOZIN ANYHYDROUS;Togliflozin;CSG 452(hydrate);Tofogliflozin(CSG452);Tofogliflozin (hydrate);TOFOGLIFLOZIN USP/EP/BP;Tofogliflozin anyhydrous;Tofogliflozin hydrate (1:1);Tofogliflozin Hydrate (JAN)
CBNumber
CB92667680
Molecular Formula
C22H26O6.H2O
Formula Weight
404.46
MOL File
1201913-82-7.mol
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TOFOGLIFLOZIN Property

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23509
Product name
Tofogliflozin (hydrate)
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23509
Product name
Tofogliflozin (hydrate)
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
23509
Product name
Tofogliflozin (hydrate)
Purity
≥95%
Packaging
10mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
23509
Product name
Tofogliflozin (hydrate)
Purity
≥95%
Packaging
25mg
Price
$420
Updated
2024/03/01
ChemScene
Product number
CS-3792
Product name
Tofogliflozin(hydrate)
Purity
98.85%
Packaging
10mg
Price
$160
Updated
2021/12/16
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TOFOGLIFLOZIN Chemical Properties,Usage,Production

Description

Tofogliflozin hydrate, which is a sodium-glucose co-transporter 2 inhibitor, was approved in Japan for the treatment of type 2 diabetes at the same time as luseogliflozin hydrate (XIX). The drug was discovered by Chugai Pharmaceutical and jointly developed with Sanofi-Aventis and Kowa. Tofogliflozin hydrate reduces glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2, and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys.

Synthesis

Reduction of commercially available 2-bromoterephtalic acid (268) through the use of trimethoxyborane and borane- THF proceeded in 89% yield to afford diol 269. Subjection of this compound to 2-methoxypropene (270) under acidic conditions generated bis-acetonide 271. This bromide then underwent lithium¨Chalogen exchange followed by exposure to magnesium bromide and treatment with lactone 272 (which was prepared by persilylation of commercially available (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2Hpyran- 2-one (277). This mixture was worked up with aqueous ammonium chloride and upon treatment with p-TsOH in methanol resulted in spiroacetal 273. Next, global protection of all alcohol functionalities within 273 was affected by reaction with methylchloroformate and DMAP in acetonitrile. The benzyl carbonate within 274 was selectively exchanged via Suzuki coupling with 4-ethylphenylboronic acid (275) to afford methylene dibenzyl system 276. Subsequent treatment with aqueous sodium hydroxide in methanol followed by crystallization from 1:6 acetone and water furnished the desired product tofogliflozin hydrate (XXXIV) in 75% yield.

TOFOGLIFLOZIN Preparation Products And Raw materials

Raw materials

Preparation Products

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TOFOGLIFLOZIN Suppliers

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View Lastest Price from TOFOGLIFLOZIN manufacturers

Qiuxian Baitai New Material Co., LTD
Product
TOFOGLIFLOZIN 1201913-82-7
Price
US $216.00/mg
Min. Order
1g
Purity
99.99%
Supply Ability
5ton/Month
Release date
2021-12-03
Career Henan Chemical Co
Product
Tofogliflozin (hydrate) 1201913-82-7
Price
US $2.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
100kg
Release date
2019-12-20

1201913-82-7, TOFOGLIFLOZINRelated Search:

Crizotinib Plx-4032 (RG7024) SERGLIFLOZIN Ertugliflozin L-pyroglutamic acid Tofogliflozin 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Acetoxy Empagliflozin Dexrazoxane Acarbose Gliclazide PF-04971729 Teneligliptin Hydrobromide Pioglitazone hydrochloride Sofosbuvir D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- Dapagliflozin Empagliflozin Canagliflozin

  • Tofogliflozin (hydrate)
  • (1S,3'R,4'S,5'S,6'R)-6-[(4-Ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol hydrate (1:1)
  • Tofogliflozin hydrate (1:1)
  • Tofogliflozin Monohydrate
  • Tofogliflozin hydrate (1:1)-API
  • CSG452; CSG-452; TOFOGLIFLOZIN; CSG 452; UNII-554245W62TTOFOGLIFLOZIN [INN]; TOFOGLIFLOZIN ANYHYDROUS
  • Tofogliflozin anyhydrous
  • UNII-554245W62TTofogliflozin [INN]
  • CSG 452(hydrate)
  • (3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol,hydrate
  • Tofogliflozin(CSG452)
  • Tofogliflozin Hydrate (JAN)
  • Tofogliflozin hydrate (CSG-452 hydrate)
  • TOFOGLIFLOZIN USP/EP/BP
  • Togliflozin
  • Tofogliflozin Monohydrate（CSG 452 hydrate）
  • (1S,3'R,4'S,5'S,6'R)-6-(4-Ethylbenzyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4',5'-triol hydrate
  • 1201913-82-7
  • C22H26O6H2O
  • API