ChemicalBook > CAS DataBase List > TOFOGLIFLOZIN

TOFOGLIFLOZIN

Product Name
TOFOGLIFLOZIN
CAS No.
1201913-82-7
Chemical Name
TOFOGLIFLOZIN
Synonyms
Tofogliflozin Monohydrate;CSG452; CSG-452; TOFOGLIFLOZIN; CSG 452; UNII-554245W62TTOFOGLIFLOZIN [INN]; TOFOGLIFLOZIN ANYHYDROUS;Togliflozin;CSG 452(hydrate);Tofogliflozin(CSG452);Tofogliflozin (hydrate);TOFOGLIFLOZIN USP/EP/BP;Tofogliflozin anyhydrous;Tofogliflozin hydrate (1:1);Tofogliflozin Hydrate (JAN)
CBNumber
CB92667680
Molecular Formula
C22H26O6.H2O
Formula Weight
404.46
MOL File
1201913-82-7.mol
More
Less

TOFOGLIFLOZIN Property

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml
form 
A crystalline solid
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
23509
Product name
Tofogliflozin (hydrate)
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23509
Product name
Tofogliflozin (hydrate)
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
23509
Product name
Tofogliflozin (hydrate)
Purity
≥95%
Packaging
10mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
23509
Product name
Tofogliflozin (hydrate)
Purity
≥95%
Packaging
25mg
Price
$420
Updated
2024/03/01
ChemScene
Product number
CS-3792
Product name
Tofogliflozin(hydrate)
Purity
98.85%
Packaging
10mg
Price
$160
Updated
2021/12/16
More
Less

TOFOGLIFLOZIN Chemical Properties,Usage,Production

Description

Tofogliflozin hydrate, which is a sodium-glucose co-transporter 2 inhibitor, was approved in Japan for the treatment of type 2 diabetes at the same time as luseogliflozin hydrate (XIX). The drug was discovered by Chugai Pharmaceutical and jointly developed with Sanofi-Aventis and Kowa. Tofogliflozin hydrate reduces glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2, and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys.

Synthesis

Reduction of commercially available 2-bromoterephtalic acid (268) through the use of trimethoxyborane and borane- THF proceeded in 89% yield to afford diol 269. Subjection of this compound to 2-methoxypropene (270) under acidic conditions generated bis-acetonide 271. This bromide then underwent lithium¨Chalogen exchange followed by exposure to magnesium bromide and treatment with lactone 272 (which was prepared by persilylation of commercially available (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2Hpyran- 2-one (277). This mixture was worked up with aqueous ammonium chloride and upon treatment with p-TsOH in methanol resulted in spiroacetal 273. Next, global protection of all alcohol functionalities within 273 was affected by reaction with methylchloroformate and DMAP in acetonitrile. The benzyl carbonate within 274 was selectively exchanged via Suzuki coupling with 4-ethylphenylboronic acid (275) to afford methylene dibenzyl system 276. Subsequent treatment with aqueous sodium hydroxide in methanol followed by crystallization from 1:6 acetone and water furnished the desired product tofogliflozin hydrate (XXXIV) in 75% yield.

TOFOGLIFLOZIN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

TOFOGLIFLOZIN Suppliers

China 89 United Kingdom 1 United States 6 Global 96
Shanghai Neff Biotechnology Co., LTD
Tel
14782051321
Email
market@lifebiology.cn
Country
China
ProdList
147
Advantage
58
Anhui Lianchuang Biological Medicine Co.,Ltd
Tel
0551-68779238 18056025720
Email
sales3@lcywhx.com
Country
China
ProdList
168
Advantage
57
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7854
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3422
Advantage
58
Chongqing Carechem Co.,Ltd.
Tel
18680818008/15802381793
Fax
086-23-86109835
Email
cqudgh@126.com
Country
China
ProdList
57
Advantage
58
Beijing Qinling Mountains Pharmaceutical Co., Ltd.
Tel
010-61241352 18901327973
Email
sales@qlmed.com
Country
China
ProdList
516
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Fax
021-50426030
Email
2630597085@qq.com
Country
China
ProdList
1889
Advantage
55
Tianjin SaiCheng Science and Technology Development Co., Ltd.
Tel
022-25349927 15900252761
Fax
022-25349927
Email
saichen_sales@hotmail.com
Country
China
ProdList
101
Advantage
55
CHMA Chemical Technology (Shanghai) Co., Ltd
Tel
021-61556450 15800904410
Fax
021-61556450
Country
China
ProdList
2837
Advantage
58
Wuhan Bo-Sen Biological Technology Co., Ltd
Tel
027-51335350 15107175693
Fax
027-51335350
Email
bosenyuan@foxmail.com
Country
China
ProdList
192
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
ATK CHEMICAL COMPANY LIMITED
Tel
3429815786 13301662590
Fax
+86-21-51619052
Email
sales@atkchemical.com
Country
China
ProdList
10006
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
1647
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9756
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1992
Advantage
55
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876 13667159345
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
1942
Advantage
55
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9507
Advantage
60
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9908
Advantage
58
Wuhan NewBaiChuan Pharmaceutical Co., Ltd.
Tel
027-50476178
Fax
QQ644526144
Email
644526144@qq.com
Country
China
ProdList
418
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9960
Advantage
58
Abydos Scientific
Tel
025-84767922 18936879710
Email
sales@abydoscientific.com
Country
China
ProdList
1029
Advantage
58
Wuhan Xinbaichuan Pharmaceutical Technology Co., Ltd.
Tel
027-50478167
Fax
QQ 252994272
Email
252994272@qq.com
Country
China
ProdList
277
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4698
Advantage
58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
ProdList
1991
Advantage
58
Yunfei Pharmaceutical(Shenzhen) Co., Ltd.
Tel
0755-61160828 15994832653
Fax
0755-61160828
Email
hulixiu@yunfeipharma.com
Country
China
ProdList
249
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
Qiuxian Baitai New Material Co., LTD
Tel
+8618330912755
Fax
+8619932103556
Email
sale2@hbyalin.com
Country
China
ProdList
1677
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
28506
Advantage
58
AFINE CHEMICALS LIMITED
Tel
0571-85134551 18958018566;
Fax
008657185134895
Email
info@afinechem.com
Country
China
ProdList
15377
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
9126
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6313
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9414
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22968
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-13773155751 19901447308
Email
260924549@qq.com
Country
China
ProdList
8709
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Wuhan Dingtong Pharmaceutical Co., Ltd
Tel
027-027-59207795 18327179646
Fax
027-59207795
Email
18327179646@163.com
Country
China
ProdList
1987
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-83989310 18627915365
Fax
027-83989310
Email
2658488909@qq.com
Country
China
ProdList
1297
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 15093356674;
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29826
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-020-82000279 18988968278
Fax
QQ：3283937693
Email
sales@ubiochem.com
Country
China
ProdList
2414
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
chenjw@absin.cn
Country
China
ProdList
24734
Advantage
58
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
0185-0185-07139096 18507139096
Fax
QQ:1925957016
Email
18507139096@163.com
Country
China
ProdList
3855
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
More
Less

View Lastest Price from TOFOGLIFLOZIN manufacturers

Qiuxian Baitai New Material Co., LTD
Product
TOFOGLIFLOZIN 1201913-82-7
Price
US $216.00/mg
Min. Order
1g
Purity
99.99%
Supply Ability
5ton/Month
Release date
2021-12-03
Dideu Industries Group Limited
Product
TOFOGLIFLOZIN 1201913-82-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-15
Career Henan Chemical Co
Product
Tofogliflozin (hydrate) 1201913-82-7
Price
US $2.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
100kg
Release date
2019-12-20

1201913-82-7, TOFOGLIFLOZINRelated Search:

Crizotinib Plx-4032 (RG7024) SERGLIFLOZIN Ertugliflozin L-pyroglutamic acid Tofogliflozin 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Acetoxy Empagliflozin Dexrazoxane Acarbose Gliclazide PF-04971729 Teneligliptin Hydrobromide Pioglitazone hydrochloride Sofosbuvir D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- Dapagliflozin Empagliflozin Canagliflozin

  • Tofogliflozin (hydrate)
  • (1S,3'R,4'S,5'S,6'R)-6-[(4-Ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol hydrate (1:1)
  • Tofogliflozin hydrate (1:1)
  • Tofogliflozin Monohydrate
  • Tofogliflozin hydrate (1:1)-API
  • CSG452; CSG-452; TOFOGLIFLOZIN; CSG 452; UNII-554245W62TTOFOGLIFLOZIN [INN]; TOFOGLIFLOZIN ANYHYDROUS
  • Tofogliflozin anyhydrous
  • UNII-554245W62TTofogliflozin [INN]
  • CSG 452(hydrate)
  • (3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol,hydrate
  • Tofogliflozin(CSG452)
  • Tofogliflozin Hydrate (JAN)
  • Tofogliflozin hydrate (CSG-452 hydrate)
  • TOFOGLIFLOZIN USP/EP/BP
  • Togliflozin
  • Tofogliflozin Monohydrate（CSG 452 hydrate）
  • 1201913-82-7
  • C22H26O6H2O
  • API