ChemicalBook > CAS DataBase List > BIX 01294

BIX 01294

Product Name
BIX 01294
CAS No.
1392399-03-9
Chemical Name
BIX 01294
Synonyms
CS-1418;BIX 01204;BIX01294 HCl;BIX01294 triHCl;BIX 01294 USP/EP/BP;BIX01294 hydrochloride;BIX01294 3hydrochloride;Trihydrochloride Hydrate;BIX 01294 Trihydrochloride Hydrate;BIX01294 hydrochloride BIX-01294 HCL
CBNumber
CB92677401
Molecular Formula
C28H41Cl3N6O2
Formula Weight
600.02314
MOL File
1392399-03-9.mol
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BIX 01294 Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: >20mg/mL
form 
powder
color 
white
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Safety

WGK Germany 
3
HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B9311
Product name
BIX 01294 trihydrochloride hydrate
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$221
Updated
2024/03/01
Sigma-Aldrich
Product number
B9311
Product name
BIX 01294 trihydrochloride hydrate
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$525
Updated
2024/03/01
TCI Chemical
Product number
B4211
Product name
BIX 01294 Trihydrochloride Hydrate
Purity
>85.0%(N)
Packaging
25mg
Price
$608
Updated
2024/03/01
TRC
Product number
B591600
Product name
BIX01294Trihydrochloride
Packaging
250mg
Price
$1175
Updated
2021/12/16
Biosynth Carbosynth
Product number
BB162787
Product name
BIX 01294
Packaging
50mg
Price
$437.5
Updated
2021/12/16
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BIX 01294 Chemical Properties,Usage,Production

Uses

BIX 01294 trihydrochloride hydrate has been used:

  • as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
  • to investigate the role of G9a in neuroblastoma tumor growth
  • as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines

General Description

BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.

Biochem/physiol Actions

BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.

storage

room temperature (desiccate)

BIX 01294 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIX 01294 Suppliers

TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75

1392399-03-9, BIX 01294Related Search:


  • BIX 01294 Trihydrochloride Hydrate
  • 4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-, hydrochloride (1:3)
  • 2-(Hexahydro-4-Methyl-1H-1,4-Diazepin-1-yl)-6,7-Dimethoxy-[1-(Phenylmethyl)-4-Piperidynyl]-4-Quinazolinamine Trihydrochloride BIX01294 hydrochloride
  • BIX01294 hydrochloride
  • BIX01294 3hydrochloride
  • Trihydrochloride Hydrate
  • N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
  • BIX 01204
  • CS-1418
  • N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrochloride
  • N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan -1-yl)-4-quinazolinamine trihydrochloride
  • BIX 01294 Trihydrochloride Hydrate&gt
  • BIX01294 HCl
  • BIX 01294 USP/EP/BP
  • N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride
  • BIX01294 triHCl
  • BIX01294 hydrochloride BIX-01294 HCL
  • SUV39H1(H320R),BIX-01294 trihydrochloride,p21,recurrent,Cdkn1a,MLKL,H3K9me3,inhibit,Histone Methyltransferase,PRMT1,p53,Autophagy,Inhibitor,H3K9me2,BIX 01294 trihydrochloride,Gadd45a,BIX01294 trihydrochloride
  • 1392399-03-9
  • C28H38N6O23HClxH2O
  • Inhibitors