BIX 01294
- Product Name
- BIX 01294
- CAS No.
- 1392399-03-9
- Chemical Name
- BIX 01294
- Synonyms
- CS-1418;BIX 01204;BIX01294 HCl;BIX01294 triHCl;BIX 01294 USP/EP/BP;BIX01294 hydrochloride;BIX01294 3hydrochloride;Trihydrochloride Hydrate;BIX 01294 Trihydrochloride Hydrate;BIX01294 hydrochloride BIX-01294 HCL
- CBNumber
- CB92677401
- Molecular Formula
- C28H41Cl3N6O2
- Formula Weight
- 600.02314
- MOL File
- 1392399-03-9.mol
BIX 01294 Property
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: >20mg/mL
- form
- powder
- color
- white
Safety
- WGK Germany
- 3
- HS Code
- 2933.99.8290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B9311
- Product name
- BIX 01294 trihydrochloride hydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $221
- Updated
- 2024/03/01
- Product number
- B9311
- Product name
- BIX 01294 trihydrochloride hydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $525
- Updated
- 2024/03/01
- Product number
- B4211
- Product name
- BIX 01294 Trihydrochloride Hydrate
- Purity
- >85.0%(N)
- Packaging
- 25mg
- Price
- $608
- Updated
- 2024/03/01
- Product number
- B591600
- Product name
- BIX01294Trihydrochloride
- Packaging
- 250mg
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- BB162787
- Product name
- BIX 01294
- Packaging
- 50mg
- Price
- $437.5
- Updated
- 2021/12/16
BIX 01294 Chemical Properties,Usage,Production
Uses
BIX 01294 trihydrochloride hydrate has been used:
- as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
- to investigate the role of G9a in neuroblastoma tumor growth
- as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines
General Description
BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.
Biochem/physiol Actions
BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.
storage
room temperature (desiccate)
BIX 01294 Preparation Products And Raw materials
Raw materials
Preparation Products
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