ChemicalBook > CAS DataBase List > BIX 01294

BIX 01294

Product Name: BIX 01294
CAS No.: 1392399-03-9
Chemical Name: BIX 01294
Synonyms: CS-1418;BIX 01204;BIX01294 HCl;BIX01294 triHCl;BIX 01294 USP/EP/BP;BIX01294 hydrochloride;BIX01294 3hydrochloride;Trihydrochloride Hydrate;BIX 01294 Trihydrochloride Hydrate;BIX01294 hydrochloride BIX-01294 HCL
CBNumber: CB92677401
Molecular Formula: C28H41Cl3N6O2
Formula Weight: 600.02314
MOL File: 1392399-03-9.mol

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BIX 01294 Property

storage temp.: Inert atmosphere,2-8°C
solubility: H2O: >20mg/mL
form: powder
color: white

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Safety

WGK Germany: 3
HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B9311
Product name: BIX 01294 trihydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 5 mg
Price: $227
Updated: 2025/07/31

Sigma-Aldrich

Product number: B9311
Product name: BIX 01294 trihydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 25 mg
Price: $630
Updated: 2025/07/31

Sigma-Aldrich

Product number: B9311
Product name: BIX 01294 trihydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $221
Updated: 2024/03/01

Sigma-Aldrich

Product number: B9311
Product name: BIX 01294 trihydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $525
Updated: 2024/03/01

TCI Chemical

Product number: B4211
Product name: BIX 01294 Trihydrochloride Hydrate
Purity: >85.0%(N)
Packaging: 25mg
Price: $608
Updated: 2024/03/01

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BIX 01294 Chemical Properties,Usage,Production

Uses

BIX 01294 trihydrochloride hydrate has been used:

as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
to investigate the role of G9a in neuroblastoma tumor growth
as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines

General Description

BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.

Biochem/physiol Actions

BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.

in vivo

BIX-01294 trihydrochloride (10 mg/kg; IP; three times a week for 2 weeks) significantly reduces tumor growth and tumor burden in recurrent tumor cells. Primary tumor growth is not inhibited^[1].

Animal Model:	Female MMTV-rtTA;TetO-Her2/neu (MTB;TAN) and TetO-Her2/neu (TAN) mice with recurrent or primary tumor cells^[1]
Dosage:	10 mg/kg
Administration:	IP; three times a week for 2 weeks
Result:	Significantly reduced tumor growth and tumor burden in recurrent tumor cells. Primary tumor growth was not inhibited. Slowed the growth of orthotopic recurrent tumors in athymic nude recipients.

storage

room temperature (desiccate)

BIX 01294 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIX 01294 Suppliers

Americas 1 China 88 Europe 1 India 1 Japan 1 United Kingdom 1 United States 9 Global 102

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1392399-03-9, BIX 01294Related Search:

Tazemetostat GSK J4 HCl GSK 343 (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol MM-102 OG-L002

BIX 01294 Trihydrochloride Hydrate

4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-, hydrochloride (1:3)

2-(Hexahydro-4-Methyl-1H-1,4-Diazepin-1-yl)-6,7-Dimethoxy-[1-(Phenylmethyl)-4-Piperidynyl]-4-Quinazolinamine Trihydrochloride BIX01294 hydrochloride

BIX01294 hydrochloride

BIX01294 3hydrochloride

Trihydrochloride Hydrate

N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

BIX 01204

CS-1418

N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrochloride

N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan -1-yl)-4-quinazolinamine trihydrochloride

BIX 01294 Trihydrochloride Hydrate&gt

BIX01294 HCl

BIX 01294 USP/EP/BP

N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride

BIX01294 triHCl

BIX01294 hydrochloride BIX-01294 HCL

SUV39H1(H320R),BIX-01294 trihydrochloride,p21,recurrent,Cdkn1a,MLKL,H3K9me3,inhibit,Histone Methyltransferase,PRMT1,p53,Autophagy,Inhibitor,H3K9me2,BIX 01294 trihydrochloride,Gadd45a,BIX01294 trihydrochloride

BIX-01294 trihydrochloride, 10 mM in DMSO

1392399-03-9

C28H38N6O23HClxH2O

Inhibitors