ChemicalBook > CAS DataBase List > UNC 669

UNC 669

Product Name
UNC 669
CAS No.
1314241-44-5
Chemical Name
UNC 669
Synonyms
UNC699;UNC 669;CS-1146;UNC669, >=98%;UNC 669; UNC-669;UNC 669 USP/EP/BP;UNC669, L3MBTL antagonist;UNC669 L3MBTL antagonist UNC-669;(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone;(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
CBNumber
CB92682025
Molecular Formula
C15H20BrN3O
Formula Weight
338.24
MOL File
1314241-44-5.mol
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UNC 669 Property

Boiling point:
458.0±45.0 °C(Predicted)
Density 
1.424±0.06 g/cm3(Predicted)
storage temp. 
Store at -20° C
solubility 
insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO
form 
solid
pka
9.78±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10875
Product name
UNC669
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
10875
Product name
UNC669
Purity
≥98%
Packaging
10mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
10875
Product name
UNC669
Purity
≥98%
Packaging
25mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
10875
Product name
UNC669
Purity
≥98%
Packaging
50mg
Price
$161
Updated
2024/03/01
TRC
Product number
B687340
Product name
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
Packaging
50mg
Price
$120
Updated
2021/12/16
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UNC 669 Chemical Properties,Usage,Production

Uses

(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT).

Definition

ChEBI: (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is an aromatic carboxylic acid and a pyridinemonocarboxylic acid.

Biological Activity

unc 669 is a potent antagonist of l3mbtl1 (ic50=4.2 μm) and l3mbtl3 (ic50=3.1 μm).there is less bio-data supported for unc669. unc1679 is an analog of unc669. unc1215 is the first potent and selective antagonism of a methyl-lysine reader protein, l3mbtl3, which antagonizes the mono- and dimethyl-lysine reading function of l3mbtl3. [1]lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. unc1679 maintains in vitro and cellular potency with improved selectivity against other mbt-containing proteins. the antagonists described were also found to effectively interact with unlabeled endogenous l3mbtl3 in cells. [1]

target

L3MBTL1

References

1. james li, korboukh vk, krichevsky l et al. small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for l3mbtl3. j med chem. 2013 sep 26;56(18):7358-71. doi: 10.1021/jm400919p. epub 2013 sep 16.

UNC 669 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC 669 Suppliers

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View Lastest Price from UNC 669 manufacturers

Career Henan Chemical Co
Product
UNC 669 314241-44-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

1314241-44-5, UNC 669Related Search:

UNC 0224 UNC3866 UNC0379 UNC2250 UNC-926 Hydochloride UNC569 UNC0646 NUC-7738 UNC2025 UNC0638 UNC-0642 UNC 0631 UNC 1999 Tazemetostat (EPZ-6438) UNC-1215 PFI3 BroMosporine PFI-1

  • CS-1146
  • UNC 669; UNC-669
  • UNC 669
  • (5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone
  • UNC699
  • (5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone UNC669
  • UNC669, >=98%
  • (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
  • METHANONE, (5-BROMO-3-PYRIDINYL)[4-(1-PYRROLIDINYL)-1-PIPERIDINYL]-
  • UNC 669 USP/EP/BP
  • UNC669 L3MBTL antagonist UNC-669
  • UNC669, L3MBTL antagonist
  • 1314241-44-5
  • 314241-44-5
  • API
  • Inhibitors