UNC 669

ChemicalBook > CAS DataBase List > UNC 669

Product Name: UNC 669
CAS No.: 1314241-44-5
Chemical Name: UNC 669
Synonyms: UNC699;UNC 669;CS-1146;UNC669, >=98%;UNC 669; UNC-669;UNC 669 USP/EP/BP;UNC669 L3MBTL antagonist UNC-669;(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone;(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone;METHANONE, (5-BROMO-3-PYRIDINYL)[4-(1-PYRROLIDINYL)-1-PIPERIDINYL]-
CBNumber: CB92682025
Molecular Formula: C15H20BrN3O
Formula Weight: 338.24
MOL File: 1314241-44-5.mol

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UNC 669 Property

Boiling point:: 458.0±45.0 °C(Predicted)
Density: 1.424±0.06 g/cm3(Predicted)
storage temp.: Store at -20° C
solubility: insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO
form: solid
pka: 9.78±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10875
Product name: UNC669
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 10875
Product name: UNC669
Purity: ≥98%
Packaging: 10mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 10875
Product name: UNC669
Purity: ≥98%
Packaging: 25mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 10875
Product name: UNC669
Purity: ≥98%
Packaging: 50mg
Price: $161
Updated: 2024/03/01

TRC

Product number: B687340
Product name: (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
Packaging: 50mg
Price: $120
Updated: 2021/12/16

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UNC 669 Chemical Properties,Usage,Production

Uses

(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT).

Definition

ChEBI: (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is an aromatic carboxylic acid and a pyridinemonocarboxylic acid.

Biological Activity

unc 669 is a potent antagonist of l3mbtl1 (ic50=4.2 μm) and l3mbtl3 (ic50=3.1 μm).there is less bio-data supported for unc669. unc1679 is an analog of unc669. unc1215 is the first potent and selective antagonism of a methyl-lysine reader protein, l3mbtl3, which antagonizes the mono- and dimethyl-lysine reading function of l3mbtl3. [1]lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. unc1679 maintains in vitro and cellular potency with improved selectivity against other mbt-containing proteins. the antagonists described were also found to effectively interact with unlabeled endogenous l3mbtl3 in cells. [1]

target

L3MBTL1

References

1. james li, korboukh vk, krichevsky l et al. small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for l3mbtl3. j med chem. 2013 sep 26;56(18):7358-71. doi: 10.1021/jm400919p. epub 2013 sep 16.

UNC 669 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from UNC 669 manufacturers

Career Henan Chemical Co

Product: UNC 669 314241-44-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

1314241-44-5, UNC 669Related Search:

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CS-1146

UNC 669; UNC-669

UNC 669

(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone

UNC699

(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone UNC669

UNC669, >=98%

(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone

METHANONE, (5-BROMO-3-PYRIDINYL)[4-(1-PYRROLIDINYL)-1-PIPERIDINYL]-

UNC 669 USP/EP/BP

UNC669 L3MBTL antagonist UNC-669

1314241-44-5

314241-44-5

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