ChemicalBook > CAS DataBase List > 4-Hydroxybenzamide

4-Hydroxybenzamide

Product Name
4-Hydroxybenzamide
CAS No.
619-57-8
Chemical Name
4-Hydroxybenzamide
Synonyms
4-HYDROXYBENZAMIDE;P-HYDROXYBENZAMIDE;Benzamide,p-hydroxy-;Benzamide,4-hydroxy-;4-Hydroxybenzamide>4-HYDROXYBENZAMIDE 98%;4-HYDROXYBENZAMIDE, 97+%;4-Hydroxybenzamide, 98+%;4-Hydroxy-benzoesaeure-amid;Benzamide, 4-hydroxy- (9CI)
CBNumber
CB9271791
Molecular Formula
C7H7NO2
Formula Weight
137.14
MOL File
619-57-8.mol
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4-Hydroxybenzamide Property

Melting point:
161-162 °C (lit.)
Boiling point:
345.3±25.0 °C(Predicted)
Density 
1.286±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
8.60±0.13(Predicted)
color 
White to Light yellow to Dark green
BRN 
1906921
InChI
InChI=1S/C7H7NO2/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
InChIKey
QXSAKPUBHTZHKW-UHFFFAOYSA-N
SMILES
C(N)(=O)C1=CC=C(O)C=C1
CAS DataBase Reference
619-57-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
270253
Product name
4-Hydroxybenzamide
Purity
98%
Packaging
5g
Price
$16.04
Updated
2024/03/01
Sigma-Aldrich
Product number
270253
Product name
4-Hydroxybenzamide
Purity
98%
Packaging
25g
Price
$105.6
Updated
2024/03/01
TCI Chemical
Product number
H0200
Product name
4-Hydroxybenzamide
Purity
>98.0%(N)
Packaging
5g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
H0200
Product name
4-Hydroxybenzamide
Purity
>98.0%(N)
Packaging
25g
Price
$108
Updated
2024/03/01
Alfa Aesar
Product number
B24222
Product name
4-Hydroxybenzamide, 98+%
Packaging
5g
Price
$31.65
Updated
2024/03/01
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4-Hydroxybenzamide Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

4-Hydroxybenzamide is a secondary metabolite from marine sponge Phakellia fusca.

Uses

4-Hydroxybenzamide was used in the synthesis of balanol, a potent protein kinase C (PKC) inhibitor.

Definition

4-Hydroxybenzamide (4HBM) is an important biological active compound that has the presence of various biological activities such as antimycobacterial, antifungal, antimicrobial, herbicidal, and antioxidant. The benzamide derivatives are also used in medical, pharmaceutical, and therapeutic applications because of their anti-inflammatory, antibacterial, and antifungal activities. The amine and carboxylic acids are important functional groups of present molecules. These are mainly utilized in the field of chemical industry. The cocrystallization of itraconazole (a very slightly soluble triazole antifungal drug) with 4-hydroxybenzamide (4OHBZA) can potentially increase the drug solubility at pH1.2 and 37 °C by 64 times[1-2].

References

[1] Ramesh P, et al. Theoretical and experimental spectroscopic studies of monomeric and dimeric structures of 4-hydroxybenzamide International Journal of Pharmaceutics. Journal of Molecular Structure, 2020; 1206: 127742.
[2] Vasilev N, et al. Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility. International Journal of Pharmaceutics, 2021; 599: 120441.

Synthesis Reference(s)

Tetrahedron Letters, 19, p. 5183, 1978 DOI: 10.1016/S0040-4039(01)85844-5

General Description

The standard molar enthalpy of formation of 4-hydroxybenzamide was studied by micro- or macrocombustion calorimetry.

Source

4-Hydroxybenzamide is a natural product found in Oxytropis falcata, Houttuynia cordata, and Streptomyces tendae with data available.

4-Hydroxybenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxybenzamide Suppliers

Americas 1 Belgium 2 CHINA 115 Czech Republic 1 Europe 2 Germany 7 India 24 Japan 2 Slovakia 1 Switzerland 5 Ukraine 1 United Kingdom 16 United States 37 Global 214
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View Lastest Price from 4-Hydroxybenzamide manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
4-Hydroxybenzamide 619-57-8
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-07
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
4-Hydroxybenzamide 619-57-8
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-07
Career Henan Chemical Co
Product
4-Hydroxybenzamide 619-57-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-02

619-57-8, 4-HydroxybenzamideRelated Search:

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  • Benzamide,4-hydroxy-
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  • P-HYDROXYBENZAMIDE
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  • 4-HYDROXYBENZAMIDE (P-HYDROXYBENZAMIDE)
  • Benzamide, 4-hydroxy- (9CI)
  • 4-HYDROXYBENZAMIDE 98%
  • 4-Hydroxybenzamide, 98+%
  • 4-HYDROXYBENZAMIDE, 97+%
  • 4-Hydroxy-benzoesaeure-amid
  • 4-Hydroxybenzamide&gt
  • 619-57-8
  • Organic Building Blocks
  • Amides
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  • Carbonyl Compounds
  • Amides
  • Carbonyl Compounds
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  • AMIDE
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts