ChemicalBook > CAS DataBase List > 3,4-Difluorobenzaldehyde

3,4-Difluorobenzaldehyde

Product Name: 3,4-Difluorobenzaldehyde
CAS No.: 34036-07-2
Chemical Name: 3,4-Difluorobenzaldehyde
Synonyms: 3,4-Difluorobenzalde;3,4-fluorobenzaldehyde;3,4-Difluorbenzaldehyd;3,4-DIFLUOROBENZALDEHYDE;3,4-DIFLOUROBENZALDEHYDE;3,6-Difluoroacetophenone;3, 4-2 fluoro benzaldehyde;3,4-Difluorobenzaldehyde>Benzaldehyde, 3,4-difluoro-;3,4-Difluorobenzaldehyde 98%
CBNumber: CB9275911
Molecular Formula: C7H4F2O
Formula Weight: 142.1
MOL File: 34036-07-2.mol

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3,4-Difluorobenzaldehyde Property

Boiling point:: 53-55°C (15 mmHg)
Density: 1.288 g/mL at 25 °C (lit.)
refractive index: n20/D 1.5(lit.)
Flash point:: 150 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 3.962g/l
form: Liquid
Specific Gravity: 1.288
color: Clear colorless to yellow
Sensitive: Air Sensitive
BRN: 2241231
InChI: InChI=1S/C7H4F2O/c8-6-2-1-5(4-10)3-7(6)9/h1-4H
InChIKey: JPHKMYXKNKLNDF-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(F)C(F)=C1
CAS DataBase Reference: 34036-07-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39-36/37
WGK Germany: 2
F: 10-21
HazardClass: IRRITANT
HS Code: 29124990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 265160
Product name: 3,4-Difluorobenzaldehyde
Purity: 97%
Packaging: 5g
Price: $49.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 265160
Product name: 3,4-Difluorobenzaldehyde
Purity: 97%
Packaging: 25g
Price: $114.1
Updated: 2025/07/31

TCI Chemical

Product number: D2340
Product name: 3,4-Difluorobenzaldehyde
Purity: >97.0%(GC)
Packaging: 5g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: D2340
Product name: 3,4-Difluorobenzaldehyde
Purity: >97.0%(GC)
Packaging: 25g
Price: $139
Updated: 2025/07/31

TRC

Product number: D445680
Product name: 3,4-Difluorobenzaldehyde
Packaging: 10g
Price: $105
Updated: 2021/12/16

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3,4-Difluorobenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Clear Liquid

Uses

3,4-Difluorobenzaldehyde is used in the synthesis of fluorine-substituted analogs of Curcumin (C838500), as chemopreventive and/or therapeutic agents against cancers and/or against the development of drug-resistant cancer.

Uses

3,4-Difluorobenzaldehyde was used in the synthesis of 3-benzylidene 20,29-dihydrobetulinic acid derivatives.

Uses

Metabolic

Synthesis

75-29-6

348-61-8

68-12-2

34036-07-2

General procedure: a 5L four-necked flask is equipped with a mechanical stirring device and protected by nitrogen gas. Magnesium strips and 400 g of iodine granules were added sequentially in tetrahydrofuran. 41.7g of 2-chloropropane was slowly added at room temperature, and the addition time was controlled within 10 minutes, and then the reaction was warmed up to 40℃. The reaction was cooled to room temperature upon completion. A tetrahydrofuran solution of 3,4-difluorobromobenzene (654 g of 3,4-difluorobromobenzene dissolved in 700 g of tetrahydrofuran) was added dropwise at 0 to 10 °C, with the dropwise addition time controlled within 50 min. After the dropwise addition, the reaction mixture was kept at room temperature. After completion of the reaction it was again cooled to 0-10°C and a tetrahydrofuran solution of N,N-dimethylformamide (DMF) was added dropwise (291.3 g of DMF dissolved in 300 g of tetrahydrofuran) over a period of 40 min, keeping the temperature below 10°C. Subsequently 700 g of water was added dropwise and the pH was adjusted to about 4 with concentrated hydrochloric acid (about 840 g of hydrochloric acid was required). Phase separation was carried out and the aqueous phase was extracted twice with 500 g of toluene to combine the organic layers. The organic layer was sequentially washed once with 500 g of saturated saline and once more with 500 g of water. Finally, the crude product was concentrated under vacuum at 65 °C to no solvent. The crude product was purified by vacuum distillation to obtain 3,4-difluorobenzaldehyde with a purity greater than 99.5% and a yield of 86%.

References

[1] Patent: CN105859536, 2016, A. Location in patent: Paragraph 0016; 0017

3,4-Difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

trans-3,4-Difluorocinnamic acid

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View Lastest Price from 3,4-Difluorobenzaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,4-Difluorobenzaldehyde 34036-07-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-26

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3,4-Difluorobenzaldehyde 34036-07-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-28

Henan Aochuang Chemical Co.,Ltd.

Product: 3,4-Difluorobenzaldehyde 34036-07-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

34036-07-2, 3,4-DifluorobenzaldehydeRelated Search:

3,4-Difluorobenzoic acid Tetrafluorophthalic acid 2,3,4,5-Tetrafluorobenzoic acid DECAFLUOROBENZOPHENONE METHYL PENTAFLUOROBENZOATE ETHYL PENTAFLUOROBENZOATE Pentafluorobenzoic acid 3,4-Difluorobenzophenone 3',4'-DIFLUOROPROPIOPHENONE 3,4-Difluorobenzoyl chloride 3',4'-Difluoroacetophenone Pentafluorobenzoyl chloride N-PENTAFLUOROBENZOYLIMIDAZOLE 2,3,4,5,6-PENTAFLUOROBENZOPHENONE 2,3,4,5,6-PENTAFLUOROBENZAMIDE 3,4-DIFLUOROBENZAMIDE 2,4,5-Trifluorobenzoic acid 2',3',4',5',6'-PENTAFLUOROACETOPHENONE

3,4-DIFLUOROBENZALDEHYDE

3,4-Difluorobenzaldehyde,98%

3,4-Difluorobenzaldehyde 98%

3,4-Difluorbenzaldehyd

3,4-Difluorobenzalde

1,3-DiFluorobenzenebenzaldehyde

3,4-fluorobenzaldehyde

3,4-Difluorobenzaldehyde, 96% 25GR

3,4-Difluorobenzaldehyde, 96% 5GR

3,4-Difluorobenzaldehyde,96%

3,4-DIFLUOROBENZALDEHYDE FOR SYNTHESIS

3, 4-2 fluoro benzaldehyde

3,4-Difluorobenzaldehyde&gt

3,4-Difluorobenzaldehyde,>97%

Benzaldehyde, 3,4-difluoro-

3,4-Difluorobenzaldehyde ISO 9001：2015 REACH

3,4-DIFLOUROBENZALDEHYDE

3,6-Difluoroacetophenone

34036-07-2

3403-60-7

C7H4F2O

Organic Building Blocks

Carbonyl Compounds

Building Blocks

Aldehydes

Benzaldehyde series

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Miscellaneous

Aromatics

Aldehydes

Carbonyl Compounds

Fluoro-Aromatics

Fluorin-contained benzaldehyde series

bc0001