3,4-Difluorobenzaldehyde
- Product Name
- 3,4-Difluorobenzaldehyde
- CAS No.
- 34036-07-2
- Chemical Name
- 3,4-Difluorobenzaldehyde
- Synonyms
- 3,4-Difluorobenzalde;3,4-fluorobenzaldehyde;3,4-Difluorbenzaldehyd;3,4-DIFLUOROBENZALDEHYDE;3,4-DIFLOUROBENZALDEHYDE;3,6-Difluoroacetophenone;3, 4-2 fluoro benzaldehyde;3,4-Difluorobenzaldehyde>Benzaldehyde, 3,4-difluoro-;3,4-Difluorobenzaldehyde 98%
- CBNumber
- CB9275911
- Molecular Formula
- C7H4F2O
- Formula Weight
- 142.1
- MOL File
- 34036-07-2.mol
3,4-Difluorobenzaldehyde Property
- Boiling point:
- 53-55°C (15 mmHg)
- Density
- 1.288 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.5(lit.)
- Flash point:
- 150 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 3.962g/l
- form
- Liquid
- Specific Gravity
- 1.288
- color
- Clear colorless to yellow
- Sensitive
- Air Sensitive
- BRN
- 2241231
- InChI
- InChI=1S/C7H4F2O/c8-6-2-1-5(4-10)3-7(6)9/h1-4H
- InChIKey
- JPHKMYXKNKLNDF-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(F)C(F)=C1
- CAS DataBase Reference
- 34036-07-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39-36/37
- WGK Germany
- 2
- F
- 10-21
- HazardClass
- IRRITANT
- HS Code
- 29124990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 265160
- Product name
- 3,4-Difluorobenzaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $49.4
- Updated
- 2025/07/31
- Product number
- 265160
- Product name
- 3,4-Difluorobenzaldehyde
- Purity
- 97%
- Packaging
- 25g
- Price
- $114.1
- Updated
- 2025/07/31
- Product number
- D2340
- Product name
- 3,4-Difluorobenzaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- D2340
- Product name
- 3,4-Difluorobenzaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $139
- Updated
- 2025/07/31
- Product number
- D445680
- Product name
- 3,4-Difluorobenzaldehyde
- Packaging
- 10g
- Price
- $105
- Updated
- 2021/12/16
3,4-Difluorobenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Clear Liquid
Uses
3,4-Difluorobenzaldehyde is used in the synthesis of fluorine-substituted analogs of Curcumin (C838500), as chemopreventive and/or therapeutic agents against cancers and/or against the development of drug-resistant cancer.
Uses
3,4-Difluorobenzaldehyde was used in the synthesis of 3-benzylidene 20,29-dihydrobetulinic acid derivatives.
Uses
Metabolic
Synthesis
75-29-6
348-61-8
68-12-2
34036-07-2
General procedure: a 5L four-necked flask is equipped with a mechanical stirring device and protected by nitrogen gas. Magnesium strips and 400 g of iodine granules were added sequentially in tetrahydrofuran. 41.7g of 2-chloropropane was slowly added at room temperature, and the addition time was controlled within 10 minutes, and then the reaction was warmed up to 40℃. The reaction was cooled to room temperature upon completion. A tetrahydrofuran solution of 3,4-difluorobromobenzene (654 g of 3,4-difluorobromobenzene dissolved in 700 g of tetrahydrofuran) was added dropwise at 0 to 10 °C, with the dropwise addition time controlled within 50 min. After the dropwise addition, the reaction mixture was kept at room temperature. After completion of the reaction it was again cooled to 0-10°C and a tetrahydrofuran solution of N,N-dimethylformamide (DMF) was added dropwise (291.3 g of DMF dissolved in 300 g of tetrahydrofuran) over a period of 40 min, keeping the temperature below 10°C. Subsequently 700 g of water was added dropwise and the pH was adjusted to about 4 with concentrated hydrochloric acid (about 840 g of hydrochloric acid was required). Phase separation was carried out and the aqueous phase was extracted twice with 500 g of toluene to combine the organic layers. The organic layer was sequentially washed once with 500 g of saturated saline and once more with 500 g of water. Finally, the crude product was concentrated under vacuum at 65 °C to no solvent. The crude product was purified by vacuum distillation to obtain 3,4-difluorobenzaldehyde with a purity greater than 99.5% and a yield of 86%.
References
[1] Patent: CN105859536, 2016, A. Location in patent: Paragraph 0016; 0017
3,4-Difluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-Difluorobenzaldehyde manufacturers
- Product
- 3,4-Difluorobenzaldehyde 34036-07-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-26
- Product
- 3,4-Difluorobenzaldehyde 34036-07-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-28
- Product
- 3,4-Difluorobenzaldehyde 34036-07-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10