3',4'-Difluoroacetophenone

Product Name: 3',4'-Difluoroacetophenone
CAS No.: 369-33-5
Chemical Name: 3',4'-Difluoroacetophenone
Synonyms: 4´3',4'-Difluoro;3',4'-Difluoroacetop;OTAVA-BB BB7020410077;3,4-DIFLUOROACETOPHENONE;3',4'-difluoroacetophenone;3,4-Difluoroacetophenone,98%;3',4'-Difluoroacetophenone99%;3',4'-Difluoroacetophenone>3',4'-Difluoroacetophenone 99%
CBNumber: CB3130786
Molecular Formula: C8H6F2O
Formula Weight: 156.13
MOL File: 369-33-5.mol

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3',4'-Difluoroacetophenone Property

Melting point:: 19-20 °C(lit.)
Boiling point:: 94-95 °C13 mm Hg(lit.)
Density: 1.246 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4916(lit.)
Flash point:: 167 °F
storage temp.: Sealed in dry,Room Temperature
form: powder to lump to clear liquid
color: White or Colorless to Light yellow
Specific Gravity: 1.246
Water Solubility: INSOLUBLE
BRN: 2206856
InChI: 1S/C8H6F2O/c1-5(11)6-2-3-7(9)8(10)4-6/h2-4H,1H3
InChIKey: VWJSSJFLXRMYNV-UHFFFAOYSA-N
SMILES: CC(=O)c1ccc(F)c(F)c1
CAS DataBase Reference: 369-33-5(CAS DataBase Reference)
NIST Chemistry Reference: 3',4'-Difluoroacetophenone(369-33-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29147000
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 264288
Product name: 3′,4′-Difluoroacetophenone
Purity: 97%
Packaging: 5g
Price: $40.46
Updated: 2025/07/31

TCI Chemical

Product number: D1906
Product name: 3',4'-Difluoroacetophenone
Purity: >97.0%(GC)
Packaging: 5g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: D1906
Product name: 3',4'-Difluoroacetophenone
Purity: >97.0%(GC)
Packaging: 25g
Price: $77
Updated: 2025/07/31

TRC

Product number: D445548
Product name: 3'',4''-Difluoroacetophenone
Packaging: 5g
Price: $75
Updated: 2021/12/16

TRC

Product number: D445548
Product name: 3'',4''-Difluoroacetophenone
Packaging: 500mg
Price: $45
Updated: 2021/12/16

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3',4'-Difluoroacetophenone Chemical Properties,Usage,Production

Chemical Properties

clear yellowish liquid after melting

Uses

3′,4′-Difluoroacetophenone may be used in chemical synthesis.

Definition

ChEBI: 1-(3,4-Difluorophenyl)ethan-1-one is an aromatic ketone.

Synthesis

367-11-3

75-36-5

369-33-5

Anhydrous aluminum trichloride (117 g) was slowly added to a mixed solution of 1,2-difluorobenzene (50 g) with acetyl chloride (86 g) at room temperature. The formed slurry was heated to 30°C with continuous stirring. Upon completion of the reaction, the red reaction mixture was cooled to 20 °C and subsequently slowly poured into 800 g of ice-water mixture with continued stirring for 30 min. The organic phase was separated and the aqueous phase was extracted with dichloromethane (3 x 500 ml). All organic phases were combined and washed sequentially with water (2 x 500 ml), saturated sodium bicarbonate solution (2 x 500 ml) and 15% brine (2 x 500 ml), followed by drying with anhydrous sodium sulfate. The organic phases were concentrated to remove the solvent and finally distilled under reduced pressure to collect the fractions at 95 °C/13 mmHg to give 3',4'-difluoroacetophenone (51 g).

References

[1] Journal of Fluorine Chemistry, 1980, vol. 15, p. 245 - 252
[2] Journal of the Indian Chemical Society, 1982, vol. 59, # 2, p. 293 - 294
[3] Heterocycles, 1981, vol. 16, # 9, p. 1545 - 1553
[4] Journal of Medicinal Chemistry, 1979, vol. 22, # 11, p. 1385 - 1389
[5] Heterocycles, 1981, vol. 16, # 1, p. 71 - 76

3',4'-Difluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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3',4'-Difluoroacetophenone Suppliers

Americas 1 Belgium 1 Canada 1 China 215 Europe 4 France 1 Germany 5 India 7 Italy 1 Japan 5 Slovakia 1 Spain 1 Switzerland 3 Ukraine 3 United Kingdom 24 United States 40 Global 313

J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from 3',4'-Difluoroacetophenone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 3′, 4′-Difluoroacetophenone 369-33-5
Price: US $9.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100ton
Release date: 2024-08-27

Honest Joy Holdings Limited

Product: 3',4'-Difluoroacetophenone 369-33-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.6%
Supply Ability: 100 tons
Release date: 2022-02-18

Career Henan Chemical Co

Product: 3',4'-Difluoroacetophenone 369-33-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-17

369-33-5, 3',4'-Difluoroacetophenone Related Search:

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1-(3,4-Difluorophenyl)ethan-1-one

1-(3,4-DIFLUORO-PHENYL)-ETHANONE

3,4-DIFLUOROACETOPHENONE

OTAVA-BB BB7020410077

Ethanone, 1-(3,4-difluorophenyl)-

3,4-Difluoroacetophenone,98%

3',4'-Difluoro

3',4'-Difluoroacetophenone 99%

3',4'-Difluoroacetophenone99%

3,4-Difluorophenyl(methyl) ketone

3',4'-Difluoroacetop

4&acute

3,4-Difluoroacetophenone≥ 98% (GC)

3',4'-Difluoroacetophenone&gt

3',4'-difluoroacetophenone

3′,4′-Difluoroacetophenone, CAS 369-33-5

369-33-5

69-33-5

KETONE

Organic Building Blocks

Ketones

C7 to C8

Carbonyl Compounds

Building Blocks

Acetophenone Series

Aromatic Acetophenones & Derivatives (substituted)

ketone

Miscellaneous

Adehydes, Acetals & Ketones

Fluorine Compounds

C7 to C8

Carbonyl Compounds

Ketones

bc0001