3',4'-Difluoroacetophenone
- Product Name
- 3',4'-Difluoroacetophenone
- CAS No.
- 369-33-5
- Chemical Name
- 3',4'-Difluoroacetophenone
- Synonyms
- 4´3',4'-Difluoro;3',4'-Difluoroacetop;OTAVA-BB BB7020410077;3,4-DIFLUOROACETOPHENONE;3',4'-difluoroacetophenone;3,4-Difluoroacetophenone,98%;3',4'-Difluoroacetophenone99%;3',4'-Difluoroacetophenone>3',4'-Difluoroacetophenone 99%
- CBNumber
- CB3130786
- Molecular Formula
- C8H6F2O
- Formula Weight
- 156.13
- MOL File
- 369-33-5.mol
3',4'-Difluoroacetophenone Property
- Melting point:
- 19-20 °C(lit.)
- Boiling point:
- 94-95 °C13 mm Hg(lit.)
- Density
- 1.246 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.4916(lit.)
- Flash point:
- 167 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to lump to clear liquid
- color
- White or Colorless to Light yellow
- Specific Gravity
- 1.246
- Water Solubility
- INSOLUBLE
- BRN
- 2206856
- InChIKey
- VWJSSJFLXRMYNV-UHFFFAOYSA-N
- CAS DataBase Reference
- 369-33-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 3',4'-Difluoroacetophenone(369-33-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 264288
- Product name
- 3′,4′-Difluoroacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $40.46
- Updated
- 2025/07/31
- Product number
- D1906
- Product name
- 3',4'-Difluoroacetophenone
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- D1906
- Product name
- 3',4'-Difluoroacetophenone
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- D445548
- Product name
- 3'',4''-Difluoroacetophenone
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D445548
- Product name
- 3'',4''-Difluoroacetophenone
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
3',4'-Difluoroacetophenone Chemical Properties,Usage,Production
Chemical Properties
clear yellowish liquid after melting
Uses
3′,4′-Difluoroacetophenone may be used in chemical synthesis.
Definition
ChEBI: 1-(3,4-Difluorophenyl)ethan-1-one is an aromatic ketone.
Synthesis
367-11-3
75-36-5
369-33-5
Anhydrous aluminum trichloride (117 g) was slowly added to a mixed solution of 1,2-difluorobenzene (50 g) with acetyl chloride (86 g) at room temperature. The formed slurry was heated to 30°C with continuous stirring. Upon completion of the reaction, the red reaction mixture was cooled to 20 °C and subsequently slowly poured into 800 g of ice-water mixture with continued stirring for 30 min. The organic phase was separated and the aqueous phase was extracted with dichloromethane (3 x 500 ml). All organic phases were combined and washed sequentially with water (2 x 500 ml), saturated sodium bicarbonate solution (2 x 500 ml) and 15% brine (2 x 500 ml), followed by drying with anhydrous sodium sulfate. The organic phases were concentrated to remove the solvent and finally distilled under reduced pressure to collect the fractions at 95 °C/13 mmHg to give 3',4'-difluoroacetophenone (51 g).
References
[1] Journal of Fluorine Chemistry, 1980, vol. 15, p. 245 - 252
[2] Journal of the Indian Chemical Society, 1982, vol. 59, # 2, p. 293 - 294
[3] Heterocycles, 1981, vol. 16, # 9, p. 1545 - 1553
[4] Journal of Medicinal Chemistry, 1979, vol. 22, # 11, p. 1385 - 1389
[5] Heterocycles, 1981, vol. 16, # 1, p. 71 - 76
3',4'-Difluoroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
3',4'-Difluoroacetophenone Suppliers
- Tel
- --
- Fax
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- info@generalintermediates.com
- Country
- Canada
- ProdList
- 640
- Advantage
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View Lastest Price from 3',4'-Difluoroacetophenone manufacturers
- Product
- 3′, 4′-Difluoroacetophenone 369-33-5
- Price
- US $9.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100ton
- Release date
- 2024-08-27
- Product
- 3',4'-Difluoroacetophenone 369-33-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 3',4'-Difluoroacetophenone 369-33-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-17