ChemicalBook > CAS DataBase List > TMRE

TMRE

Product Name
TMRE
CAS No.
115532-52-0
Chemical Name
TMRE
Synonyms
TMRE;T 669;TMRE.ClO4;TMRE, PERCHLORATE;TMRE, 10 mM in DMSO;xanthylium perchlorate;3,6-Bis(dimethylamino);TMRE(Tetramethylrhodamine ethyl ester);TETRAMETHYLRHODAMINE ETHYL ESTER PERCHLORATE;TMRE Membrane Potential Fluorescent Probes (Red)
CBNumber
CB9279045
Molecular Formula
C26H27ClN2O7
Formula Weight
514.96
MOL File
115532-52-0.mol
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TMRE Property

Melting point:
264–266℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: soluble
form 
crystals
color 
Dark green
Appearance
dark colored solid
λmax
549 nm
Biological Applications
Detecting mitochondrial membrane potential; apoptosis assays; multidrug resistance assays
Major Application
Semi-conducting polymer nanoparticles
InChIKey
NBAOBNBFGNQAEJ-UHFFFAOYSA-M
SMILES
Cl([O-])(=O)(=O)=O.C(C1C=CC=CC=1C1C2=CC=C(N(C)C)C=C2[O+]=C2C=C(N(C)C)C=CC=12)(=O)OCC
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Safety

Hazard Codes 
Xn
Risk Statements 
20/22-36/38
Safety Statements 
26-36
WGK Germany 
3
F 
8-10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
87917
Product name
Tetramethylrhodamine ethyl ester perchlorate
Purity
suitable for fluorescence, ≥90% (HPCE)
Packaging
25mg
Price
$210
Updated
2025/07/31
Cayman Chemical
Product number
21426
Product name
Tetramethylrhodamine ethyl ester (perchlorate)
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
21426
Product name
Tetramethylrhodamine ethyl ester (perchlorate)
Purity
≥98%
Packaging
10mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
21426
Product name
Tetramethylrhodamine ethyl ester (perchlorate)
Purity
≥98%
Packaging
25mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
21426
Product name
Tetramethylrhodamine ethyl ester (perchlorate)
Purity
≥98%
Packaging
50mg
Price
$195
Updated
2024/03/01
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TMRE Chemical Properties,Usage,Production

Description

TMRE is widely used for labeling mitochondria in live cells but not compatible with fixation. This lipophilic and positively charged dye rapidly permeates plasma membrane without interacting with membrane proteins and forming aggregates. TMRE selectively accumulates in active mitochondria due to their transmembrane potential.


In addition to staining mitochondria for imaging purposes, TMRE is used for quantitative measurements of mitochondria membrane potential using Nernst equation. The dye serves as a tool to study mitochondrial function changes and cell viability in response to stimuli or pharmaceuticals of interest. Mitochondrial depolarization caused by apoptosis, necrosis or other factors is characterized by decreased membrane potential and is indicated with decreased fluorescence compared to intact cells that have polarized mitochondria.


TMRE applications include fluorescent microscopy, flow cytometry, microplate assays. The dye has an excitation maximum at 549 nm: it can be effectively excited by the blue (488 nm) or yellow-green (561 nm) lasers. Emission of the dye can be detected in PE channel (maximum at 574 nm).

Uses

Tetramethylrhodamine Ethyl Ester Perchlorate is a fluorescent probe which is used in measuring membrane potential changes in mitochondria.

Definition

ChEBI: Tetramethylrhodamine ethyl ester perchlorate is an organic perchlorate salt that has tetramethylrhodamine ethyl ester(1+) as the cation. It is used as a cell-permeant, cationic, red-orange fluorescent dye that is readily sequestered by active mitochondria. It has a role as a fluorochrome and a reagent. It is a xanthene dye and an organic perchlorate salt. It contains a tetramethylrhodamine ethyl ester(1+).

Abs/Em Maxima

552/575 nm

Excitation / Emission Maximum

550 nm/575 nm

TMRE Preparation Products And Raw materials

Raw materials

Preparation Products

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TMRE Suppliers

China 124 Germany 1 India 1 Switzerland 1 United States 15 Global 142
Xi'an Kaixin Biotechnology Co., Ltd
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Energy Chemical
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View Lastest Price from TMRE manufacturers

Career Henan Chemical Co
Product
[6-(dimethylamino)-9-(2-ethoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium,perchlorate 115532-52-0
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2019-12-31

115532-52-0, TMRERelated Search:

ETHYL METHYL ETHER 2-METHYL-1,3-PROPANEDIOL 3,3'-DIHEXYLOXACARBOCYANINE IODIDE DIHYDRORHODAMINE 123 JC-1 Rhodamine 123 NONYL ACRIDINE ORANGE TETRAMETHYLRHODAMINE METHYL ESTER PERCHLORATE TETRAMETHYLRHODAMINE, ETHYL ESTER, PERCHLORATE (TMRE) TMRE RHODAMINE B, HEXYL ESTER PERCHLORATE [3H(G)]

  • TMRE
  • TMRE, PERCHLORATE
  • TETRAMETHYLRHODAMINE ETHYL ESTER PERCHLORATE
  • XanthyliuM, 3,6-bis(diMethylaMino)-9-[2-(ethoxycarbonyl)phenyl]-, perchlorate (1:1)
  • 3,6-bis(diMethylaMino)-9-(2-(ethoxycarbonyl)phenyl)xanthyliuM
  • TMRE [TetraMethylrhodaMine, ethyl ester, perchlorate]
  • 3,6-Bis(diMethylaMino)-9-(2-(ethoxycarbonyl)phenyl)xanthyliuM perchlorate
  • 3,6-Bis(dimethylamino)
  • xanthylium perchlorate
  • T 669
  • TMRE [Tetramethylrhodamine ethyl ester] *CAS#: 115532-52-0*
  • [6-(dimethylamino)-9-(2-ethoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium,perchlorate
  • TMRE(Tetramethylrhodamine ethyl ester)
  • TMRE.ClO4
  • TMRE,Tetramethylrhodamine ethyl ester,Inhibitor,inhibit
  • TMRE, 10 mM in DMSO
  • TMRE [Tetramethylrhodamine, ethyl ester, perchlorate] - 25 mg
  • TMRE Membrane Potential Fluorescent Probes (Red)
  • 115532-52-0
  • C26H27N2O3
  • C26H27ClN2O7
  • Fluorescent Probes, Labels, Particles and Stains
  • Detection
  • Biochemicals and Reagents
  • BioChemical
  • Xanthene