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DIHYDRORHODAMINE 123

Product Name
DIHYDRORHODAMINE 123
CAS No.
109244-58-8
Chemical Name
DIHYDRORHODAMINE 123
Synonyms
DHR;D 632;DHR123;D 23806;Dihydrorhodamine;DIHYDRORHODAMINE 123;Dihydrohodamine 123;Dihydrorhodamine123(DHR123);Dihydrorhodamine 123 *CAS 109244-58-8*;DIHYDRORHODAMINE 123, FOR FLUOR-ESCENCE
CBNumber
CB3320004
Molecular Formula
C21H18N2O3
Formula Weight
346.38
MOL File
109244-58-8.mol
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DIHYDRORHODAMINE 123 Property

Melting point:
163–165℃
Boiling point:
526.9±50.0 °C(Predicted)
Density 
1.313±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: >5mg/mL
form 
powder
pka
4.70 ± 0.40, most basic, temperature: 25 °C
color 
Light red or pinkish-white
λmax
289 nm
BRN 
5989965
Biological Applications
Generating,detecting & measuring reactive oxygen species; generating,detecting & measuring reactive nitrogen species; detecting phosphates,peroxynitrile; measuring respiratory burst; chronic granulomatous disease DHR assay; screening
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
10-23
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1054
Product name
Dihydrorhodamine 123
Purity
≥95%
Packaging
2mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
D1054
Product name
Dihydrorhodamine 123
Purity
≥95%
Packaging
10mg
Price
$415
Updated
2024/03/01
Cayman Chemical
Product number
85100
Product name
Dihydrorhodamine 123
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
85100
Product name
Dihydrorhodamine 123
Purity
≥98%
Packaging
5mg
Price
$98
Updated
2024/03/01
Sigma-Aldrich
Product number
309825
Product name
Dihydrorhodamine 123 - CAS 109244-58-8 - Calbiochem
Packaging
5mg
Price
$461
Updated
2024/03/01
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DIHYDRORHODAMINE 123 Chemical Properties,Usage,Production

Description

DHR is a cell-permeable fluorogenic probe that is used as an indicator of intracellular peroxynitrite formation. It is oxidized by peroxynitrite to the highly fluorescent product rhodamine in vitro. Neither nitric oxide, superoxide, nor hydrogen peroxide alone appear to oxidize DHR. Formation of rhodamine can be monitored by fluorescence spectroscopy using excitation and emission wavelengths of 500 and 536 nm, respectively, or by absorbance spectroscopy at 500 nm (ε = 78,800 M−1cm−1). DHR has been used to investigate reactive oxygen intermediates produced by endothelial cells, eosinophils, and reactive microglia.

Uses

Dihydrorhodamine 123 is the uncharged and nonfluorescent reduction product of the mitochondrion-selective dye rhodamine 123 used for investigation of reacitve oxygen intermediates.

Uses

Dihydrorhodamine 123 (DHR) has been used for the detection of free intracellular radicals or ROS (reactive oxygen species) in head kidney-derived macrophages. It has also been used in DHR assay in red blood cells and in oxidative burst assay in neutrophils.

General Description

Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite. Dihydrorhodamine is not fluorescent unless it is converted to rhodamine 123.

Biochem/physiol Actions

Cell permeable: yes

DIHYDRORHODAMINE 123 Preparation Products And Raw materials

Raw materials

Preparation Products

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DIHYDRORHODAMINE 123 Suppliers

Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
2998
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
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TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
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58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
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sales@chem-strong.com
Country
China
ProdList
18070
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Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
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2045
Advantage
56
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
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55

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