2-Fluoro-5-trifluoromethylpyridine
Application- Product Name
- 2-Fluoro-5-trifluoromethylpyridine
- CAS No.
- 69045-82-5
- Chemical Name
- 2-Fluoro-5-trifluoromethylpyridine
- Synonyms
- uoro-6-(trifL;2-Fluoro-5-(Trichloromethyl)Py;2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-fluoro-5-(trifluoroMethyl)-;2-Fluoro-5-(trifluoromethyl)pyridine>2-Fluoro-5-(trifluoromethyl)pyridine 97%;2-Fluoro-5-(trifluoromethyl)pyridine ,98%;2-Fluoro-5-trifluoromethylpyridine ISO 9001：2015 REACH
- CBNumber
- CB9299728
- Molecular Formula
- C6H3F4N
- Formula Weight
- 165.09
- MOL File
- 69045-82-5.mol
2-Fluoro-5-trifluoromethylpyridine Property
- Boiling point:
- 118-122℃
- Density
- 1.368 g/mL at 25 °C
- Flash point:
- 35°(95°F)
- refractive index
- 1.4020
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- clear liquid
- pka
- -2.86±0.10(Predicted)
- color
- Colorless to Almost colorless
- InChI
- InChI=1S/C6H3F4N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H
- InChIKey
- UUODQIKUTGWMPT-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=C(C(F)(F)F)C=C1
- CAS DataBase Reference
- 69045-82-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-52/53-43-10
- Safety Statements
- 26-36/37/39-45-61-37-24-36-27
- RIDADR
- 1993
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 3
- PackingGroup
- Ⅲ
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H317May cause an allergic skin reaction
H402Harmful to aquatic life
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0846
- Product name
- 2-Fluoro-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- F0846
- Product name
- 2-Fluoro-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- F599010
- Product name
- 2-Fluoro-5-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- HCH0019834
- Product name
- 2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $592.05
- Updated
- 2021/12/16
- Product number
- HCH0019834
- Product name
- 2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $808.96
- Updated
- 2021/12/16
2-Fluoro-5-trifluoromethylpyridine Chemical Properties,Usage,Production
Application
2-Fluoro-5-trifluoromethylpyridine is an important chemical intermediate. By introducing fluorine atoms into the pyridine ring and pyridine side chain, it has strong lipophilicity and can play an important role in pesticides and pharmaceuticals. Its application value and market prospects are very promising.
Chemical Properties
Colorless liquid
Synthesis
In a 1-liter three-necked flask, 46.20g (0.80 mol) of KF was added, followed by 500 mL of N, N-dimethylacetamide, which was warmed to 125 °C and stirred for 30 minutes. The setup was then connected to a distillation unit for micro-vacuum distillation, during which fractions were collected, and the water content was monitored using three separate bottles. Distillation was halted when the water content reached less than 500 ppm. Subsequently, 7g (0.03 mol) of benzyl triethyl ammonium chloride and 100g (0.55 mol) of 2-chloro-5-trifluoromethylpyridine were added to the flask. A condenser was connected, and the mixture was warmed to 135 °C and stirred for 10 hours. Gas chromatography was used to monitor the reaction; the reaction was stopped when the content of 2-chloro-5-trifluoromethylpyridine in the reaction solution was less than 1%. The reaction solution was directly distilled under reduced pressure to collect the fraction at 40-45 °C / 11 mmHg, yielding 87.80g of 2-fluoro-5-trifluoromethylpyridine with a purity of 98.95% (GC) and a yield of 95.56%.
References
[1] Patent: CN106866509, 2017, A. Location in patent: Paragraph 0030; 0032; 0044; 0046
2-Fluoro-5-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-5-trifluoromethylpyridine Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
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- Advantage
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View Lastest Price from 2-Fluoro-5-trifluoromethylpyridine manufacturers
- Product
- 2-Fluoro-5-(trifluoromethyl)pyridine 69045-82-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 250kg
- Purity
- Purity: 99%
- Supply Ability
- 1000tons
- Release date
- 2025-07-20
- Product
- 2-Fluoro-5-trifluoromethylpyridine 69045-82-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 TONS
- Release date
- 2021-10-15
- Product
- 2-Fluoro-5-trifluoromethylpyridine 69045-82-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26