ChemicalBook > CAS DataBase List > Fmoc-N-methyl-D-valine

Fmoc-N-methyl-D-valine

Product Name: Fmoc-N-methyl-D-valine
CAS No.: 103478-58-6
Chemical Name: Fmoc-N-methyl-D-valine
Synonyms: Fmoc-D-N-Me-Ala-OH;FMOC-N-ME-D-VAL-OH;FMOC-D-MEVAL-OH;Fmoc-D-N-Me-Val-OH;FMOC-N-METHYL-D-VALINE;Exemestane Impurity 41;FMOC-N-ME-D-VAL 98.5+%;N-Fmoc-N-methyl-D-valine;Fmoc-N-methyl-D-valine98+%;FMOC-N-ALPHA-METHYL-D-VALINE
CBNumber: CB9301830
Molecular Formula: C21H23NO4
Formula Weight: 353.41
MOL File: 103478-58-6.mol

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Fmoc-N-methyl-D-valine Property

Boiling point:: 527.6±29.0 °C(Predicted)
Density: 1.214±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Solid
pka: 3.92±0.10(Predicted)
color: White to off-white
CAS DataBase Reference: 103478-58-6(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10
HazardClass: IRRITANT
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: F648508
Product name: Fmoc-n-methyl-d-valine
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 450806
Product name: Fmoc-n-methyl-d-valine
Packaging: 100mg
Price: $305
Updated: 2021/12/16

Usbiological

Product number: 276971
Product name: Fmoc-N-methyl-D-valine
Packaging: 1g
Price: $346
Updated: 2021/12/16

AK Scientific

Product number: J96875
Product name: Fmoc-N-methyl-D-valine
Packaging: 1g
Price: $20
Updated: 2021/12/16

Activate Scientific

Product number: AS42805-2R
Product name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylbutanoic acid
Purity: 97% ee
Packaging: 1g
Price: $29
Updated: 2021/12/16

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Fmoc-N-methyl-D-valine Chemical Properties,Usage,Production

Uses

Fmoc-D-N-Me-Val-OH is a valine derivative[1].

Synthesis

84000-01-1

103478-58-6

General procedure for the synthesis of (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl(methyl)amino)-3-methylbutanoic acid from (S)-3-Fmoc-4-isopropyl-5-oxoxoxazolidine: Fmoc-valyl oxazolidinone (2.80 g, 8.00 mmol) was dissolved in chloroform (40 mL). To this solution, trifluoroacetic acid (1.85 mL, 24.0 equiv) and triethylsilane (3.83 mL, 24.0 equiv) were added sequentially. The reaction mixture was stirred at room temperature until the reaction was complete (24-72 hours). Upon completion of the reaction, the solution was concentrated and partitioned between ether and 5% sodium bicarbonate solution. The aqueous phases were combined and the pH was adjusted to 2 with 5 M hydrochloric acid, followed by extraction with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to give Fmoc-N-methylvaline (4) as a white solid (2.35 g, 83% yield).Fmoc-N-methylvaline was recrystallized from ethyl acetate to give white acicular crystals: melting point 186-187 °C (literature value 33: 185-187 °C); low resolution mass spectra (ESI) m/z [M + H]+ 354.1 (100%), [M + Na]+ 376.1 (61%); IR spectrum (NaCl) νmax (cm-1) 3420 (broad, OH), 2964 (aliphatic CH), 1700 (C=O), 1445, 1305 (C=C); 1H NMR (300 MHz, CDCl3) δH (ppm) 7.63 (2H, d, J=7.5 Hz, ArH), 7.46 (2H, d, J=6.9 Hz, ArH), 7.26 (2H, t, J=7.2 Hz, ArH), 7.17 (2H, t, J=7.5 Hz, ArH), 4.28 (2H, m, CHCH2O), 4.22 (1H, m, (Ar)2CHCH2 ), 4.13 (1H, m, NCHCO), 2.79 (3H, d, J=4.2 Hz, NCH3), 2.02 (1H, m, CH3CHCH3), 0.88 (3H, dd, J=6.6, 19.2 Hz, CH3CHCH3), 0.72 (3H, dd, J=6.6, 13.8 Hz, CH3CHCH3) (IR spectra and 1H NMR data consistent with literature reports); 13C NMR (75 MHz, CDCl3) δC (ppm) 175.5, 159.6, 146.6, 143.9, 130.4, 129.7, 127.7, 122.6, 70.3, 66.9, 49.9, 33.1, 30.2, 22.5, 21.7 .

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

Fmoc-N-methyl-D-valine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fmoc-N-methyl-D-valine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-N-Me-D-Val-OH 103478-58-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-04-12

Career Henan Chemical Co

Product: Fmoc-N-methyl-D-valine 103478-58-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-08-31

103478-58-6, Fmoc-N-methyl-D-valineRelated Search:

DL-Norvaline Methyl salicylate Fmoc-Phe-OH Fmoc-8-amino-3,6-dioxaoctanoic acid 9-Fluorenylmethyl chloroformate Methyl acetate Valine Nalpha-Fmoc-Ndelta-trityl-L-glutamine L-Valine Fmoc-N'-methyltrityl-L-lysine D-Valine Tribenuron methyl METSULFURON METHYL L-Fmoc-Aspartic acid alpha-tert-butyl ester Kresoxim-methyl FMOC-L-Valine Fmoc-OSu Thiophanate-methyl

N-ALPHA-FMOC-N-ALPHA-METHYL-D-VALINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-D-VALINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-D-VALINE

Fmoc-D-N-Me-Val-OH

FMOC-N-ME-D-VAL 98.5+%

Fmoc-D-N-Me-Ala-OH

N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-D-valine

(R)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)-3-Methylbutanoic acid

(9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-D-Val-OH

Fmoc-N-methyl-D-valine98+%

N-Fmoc-N-methyl-D-valine

FMOC-N-ALPHA-METHYL-D-VALINE

FMOC-N-ME-D-VAL-OH

FMOC-N-METHYL-D-VALINE

FMOC-D-MEVAL-OH

(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methylbutanoic acid

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-valine

D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-

Fmoc-N-methyl-D-valine USP/EP/BP

Exemestane Impurity 41

103478-58-6

Specialty Synthesis

Unnatural Amino Acid Derivatives

N-Methyl Amino Acids

Peptide Synthesis

N-Methyl Amino Acids

Amino Acid Derivatives

Amino Acids