Fmoc-N-methyl-D-valine
- Product Name
- Fmoc-N-methyl-D-valine
- CAS No.
- 103478-58-6
- Chemical Name
- Fmoc-N-methyl-D-valine
- Synonyms
- Fmoc-D-N-Me-Ala-OH;FMOC-N-ME-D-VAL-OH;FMOC-D-MEVAL-OH;Fmoc-D-N-Me-Val-OH;FMOC-N-METHYL-D-VALINE;Exemestane Impurity 41;FMOC-N-ME-D-VAL 98.5+%;N-Fmoc-N-methyl-D-valine;Fmoc-N-methyl-D-valine98+%;FMOC-N-ALPHA-METHYL-D-VALINE
- CBNumber
- CB9301830
- Molecular Formula
- C21H23NO4
- Formula Weight
- 353.41
- MOL File
- 103478-58-6.mol
Fmoc-N-methyl-D-valine Property
- Boiling point:
- 527.6±29.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Solid
- pka
- 3.92±0.10(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 103478-58-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- F648508
- Product name
- Fmoc-n-methyl-d-valine
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 450806
- Product name
- Fmoc-n-methyl-d-valine
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 276971
- Product name
- Fmoc-N-methyl-D-valine
- Packaging
- 1g
- Price
- $346
- Updated
- 2021/12/16
- Product number
- J96875
- Product name
- Fmoc-N-methyl-D-valine
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- AS42805-2R
- Product name
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylbutanoic acid
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
Fmoc-N-methyl-D-valine Chemical Properties,Usage,Production
Uses
Fmoc-D-N-Me-Val-OH is a valine derivative[1].
Synthesis
84000-01-1
103478-58-6
General procedure for the synthesis of (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl(methyl)amino)-3-methylbutanoic acid from (S)-3-Fmoc-4-isopropyl-5-oxoxoxazolidine: Fmoc-valyl oxazolidinone (2.80 g, 8.00 mmol) was dissolved in chloroform (40 mL). To this solution, trifluoroacetic acid (1.85 mL, 24.0 equiv) and triethylsilane (3.83 mL, 24.0 equiv) were added sequentially. The reaction mixture was stirred at room temperature until the reaction was complete (24-72 hours). Upon completion of the reaction, the solution was concentrated and partitioned between ether and 5% sodium bicarbonate solution. The aqueous phases were combined and the pH was adjusted to 2 with 5 M hydrochloric acid, followed by extraction with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to give Fmoc-N-methylvaline (4) as a white solid (2.35 g, 83% yield).Fmoc-N-methylvaline was recrystallized from ethyl acetate to give white acicular crystals: melting point 186-187 °C (literature value 33: 185-187 °C); low resolution mass spectra (ESI) m/z [M + H]+ 354.1 (100%), [M + Na]+ 376.1 (61%); IR spectrum (NaCl) νmax (cm-1) 3420 (broad, OH), 2964 (aliphatic CH), 1700 (C=O), 1445, 1305 (C=C); 1H NMR (300 MHz, CDCl3) δH (ppm) 7.63 (2H, d, J=7.5 Hz, ArH), 7.46 (2H, d, J=6.9 Hz, ArH), 7.26 (2H, t, J=7.2 Hz, ArH), 7.17 (2H, t, J=7.5 Hz, ArH), 4.28 (2H, m, CHCH2O), 4.22 (1H, m, (Ar)2CHCH2 ), 4.13 (1H, m, NCHCO), 2.79 (3H, d, J=4.2 Hz, NCH3), 2.02 (1H, m, CH3CHCH3), 0.88 (3H, dd, J=6.6, 19.2 Hz, CH3CHCH3), 0.72 (3H, dd, J=6.6, 13.8 Hz, CH3CHCH3) (IR spectra and 1H NMR data consistent with literature reports); 13C NMR (75 MHz, CDCl3) δC (ppm) 175.5, 159.6, 146.6, 143.9, 130.4, 129.7, 127.7, 122.6, 70.3, 66.9, 49.9, 33.1, 30.2, 22.5, 21.7 .
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368
Fmoc-N-methyl-D-valine Preparation Products And Raw materials
Raw materials
Preparation Products
Fmoc-N-methyl-D-valine Suppliers
- Tel
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- Country
- Switzerland
- ProdList
- 6896
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View Lastest Price from Fmoc-N-methyl-D-valine manufacturers
- Product
- Fmoc-N-Me-D-Val-OH 103478-58-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-12
- Product
- Fmoc-N-methyl-D-valine 103478-58-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-08-31