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Mal-PEG1-acid

Product Name
Mal-PEG1-acid
CAS No.
760952-64-5
Chemical Name
Mal-PEG1-acid
Synonyms
Mal-PEG1-acid;Mal-PEG1-CH2CH2COOH;3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoic acid;3-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]propanoic Acid;3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid;Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-;Mal-PEG1-CH2CH2COOH/Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-
CBNumber
CB93062525
Molecular Formula
C9H11NO5
Formula Weight
213.19
MOL File
760952-64-5.mol
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Mal-PEG1-acid Property

Boiling point:
419.4±30.0 °C(Predicted)
Density 
1.383±0.06 g/cm3(Predicted)
pka
4.27±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M158213
Product name
Mal-PEG1-acid
Packaging
50mg
Price
$330
Updated
2021/12/16
ChemScene
Product number
CS-0108926
Product name
Mal-PEG1-acid
Packaging
250mg
Price
$520
Updated
2021/12/16
BroadPharm
Product number
BP-21859
Product name
Mal-PEG1-acid
Purity
98%
Packaging
250mg
Price
$575
Updated
2021/12/16
Apolloscientific
Product number
BIPG1491
Product name
Mal-PEG1-acid
Packaging
100mg
Price
$669
Updated
2021/12/16
ChemScene
Product number
CS-0108926
Product name
Mal-PEG1-acid
Packaging
100mg
Price
$300
Updated
2021/12/16
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Mal-PEG1-acid Chemical Properties,Usage,Production

Description

Mal-PEG1-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Mal-PEG1-acid is a non-cleavable ADC linker containing 1 unit PEG, which can be used to synthesize antibody drug conjugates (ADC),it is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Non-cleavable

Mal-PEG1-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mal-PEG1-acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Mal-PEG1-acid 760952-64-5
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-27

760952-64-5, Mal-PEG1-acidRelated Search:


  • Mal-PEG1-acid
  • Mal-PEG1-CH2CH2COOH
  • 3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid
  • Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-
  • Mal-PEG1-CH2CH2COOH/Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-
  • 3-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]propanoic Acid
  • 3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoic acid
  • 760952-64-5