ChemicalBook > CAS DataBase List > 19-Norethindrone acetate

19-Norethindrone acetate

Product Name
19-Norethindrone acetate
CAS No.
51-98-9
Chemical Name
19-Norethindrone acetate
Synonyms
NORETHISTERONE ACETATE;NORETHINDRONE ACETATE;ENTA;Aygestin;sh420;17-Ent;SH 420;SH-420C;Orlutate;progylut
CBNumber
CB9307049
Molecular Formula
C22H28O3
Formula Weight
340.46
MOL File
51-98-9.mol
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19-Norethindrone acetate Property

Melting point:
161-162°
Boiling point:
416.25°C (rough estimate)
Density 
1.1236 (rough estimate)
refractive index 
-34 ° (C=1, Dioxane)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol.
form 
Solid
color 
Crystals from Me2CO/hexane
Water Solubility 
3.162mg/L(10 ºC)
Merck 
14,6697
InChIKey
IMONTRJLAWHYGT-ZCPXKWAGSA-N
CAS DataBase Reference
51-98-9(CAS DataBase Reference)
NIST Chemistry Reference
Norethindrone acetate(51-98-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
40-48
Safety Statements 
36/37
WGK Germany 
3
RTECS 
RC8965000
HS Code 
29372390
Toxicity
dlt-mus-orl 1120 mg/kg/4W MUREAV 26,535,74
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R752029
Product name
NORETHINDRONE ACETATE
Purity
AldrichCPR
Packaging
50MG
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
R182265
Product name
NORETHISTERONE ACETATE
Purity
AldrichCPR
Packaging
1MG
Price
$139
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2534
Product name
Norethindrone acetate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200MG
Price
$158
Updated
2024/03/01
Sigma-Aldrich
Product number
BP267
Product name
Norethisterone acetate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
1470004
Product name
Norethindrone acetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$436
Updated
2024/03/01
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19-Norethindrone acetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Norlestrin,Parke Davis ,US,1964

Uses

Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.

Uses

Oral contraceptive (in combination with estrogen)

Definition

ChEBI: A 3-oxo Delta4-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.

Manufacturing Process

2.98 grams of 17-ethinyl-19-nor-testosterone (norethindrone) are suspended in 30 cc of acetic anhydride and a solution of 1.9 grams of p-toluenesulfonic acid in 19 cc of acetic anhydride is gradually added while cooling and stirring. Complete dissolution takes place after about one hour. After additional 30 to 60 minutes, a thick, pasty mass separates. The reaction is permitted to continue for a total period of 5 hours, whereupon water is added to the reaction mixture and the 3-enol-17-diacetate which separates after stirring for 1 to 2 hours is filtered off, washed until neutral and dried in vacuo over calcium chloride at room temperature.
In order to prepare the monoacetate, the crude diacetate is suspended in 150 cc of methanol and, after adding 1.5 cc, concentrated hydrochloric acid, heated to boiling for 15 minutes in a nitrogen atmosphere. The crude monoacetate which separates upon the addition of water after cooling is filtered off, washed and dried in vacuo over calcium chloride at room temperature. The pure 17-acetete, obtained after repeated recrystallizations from methylene chloride/hexane has a MP of 161° to 162°C.

brand name

Aygestin (Duramed); Norlutate (Parke-Davis).

Therapeutic Function

Chemical Name: 19-Nor-17α-pregn-4-en-20-yn-3one, 17-hydroxy-, acetate

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Safety Profile

Suspected carcinogen with experimental tumorigenic data. Human reproductive effects by ingestion and implant routes: menstrual cycle changes, postpartum effects, and changes in fertility. A human teratogen by an unspecified route with developmental abnormalities of the urogenital system. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in the treatment of menstrual dsorders and uterine bleedmg.

19-Norethindrone acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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19-Norethindrone acetate Suppliers

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View Lastest Price from 19-Norethindrone acetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Norethisterone Acetate 51-98-9
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
97%-103%; USP
Supply Ability
100KGS
Release date
2021-07-23
Wuhan Haorong Biotechnology Co.,Ltd
Product
19-Norethindrone acetate 51-98-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2023-07-31
Hebei Yanxi Chemical Co., Ltd.
Product
norethisterone acetate 51-98-9
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-25

51-98-9, 19-Norethindrone acetateRelated Search:

Isopropyl acetate Vinyl acetate 1-Methoxy-2-propyl acetate Glatiramer acetate Ethyl acetate POLY(VINYL ACETATE) Ethylene glycol monoethyl ether acetate Sodium acetate CHLOROPHOSPHONAZO III (-)-NORGESTREL 98 Cellulose acetate Norethindrone 2-Butoxyethyl acetate Ammonium acetate Norgestrel ACETATE NOR-1 Ethinylestradiol/Norethindrone acetate

  • SH-420C
  • 4-ESTREN-17ALPHA-ETHYNYL-17BETA-OL-3-ONE 17-ACETATE
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  • NORETHISTERONE ACETATE, IMP. G (EP): 6-KETONORETHISTERONE ACETATE, MM(CRM STANDARD)
  • NORETHISTERONE ACETATE 98+%
  • NORETHINDRONE ACETATE CRYSTALLINE
  • NORETHISTERONE ACETATE, IMP. F (EP): 6-HYDROXYNORETHISTERONE ACETATE, MM(CRM STANDARD)
  • NORETHISTERONE ACETATE, USP STANDARD
  • NORETHISTERONE ACETATE, IMP. B (EP): 3-OXO-19-NOR-17ALPHA-PREGN-5(10-EN-20YN-17YL ACETATE MM(CRM STANDARD)
  • NORETHISTERONE ACETATE, MM(CRM STANDARD)
  • NorethisteroneAcetateBp93
  • 17-Hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one acetate
  • 17α-ethynyl-17β-hydroxy-19-nor-4-androsten-3-one 17-acetate
  • 19-NOR-17ALPHA-ETHYNYLTESTOSTERONE ACETATE
  • 19-NORESTHISTERONE ACETATE
  • 19-NORETHINDRONE ACETATE
  • 19-NORETHISTERONE 17-ACETATE
  • 19-NORETHISTERONE ACETATE
  • 17a-ethynyl-19-nortestosterone 17b-acetate
  • 17ALPHA-ETHYNYL-17BETA-HYDROXY-19-NOR-4-ANDROSTEN-3-ONE 17-ACETATE
  • 17ALPHA-ETHYNYL-19-NORTESTOSTERONE ACETATE
  • 17ALPHA-ETHYNYL-19-NORTESTOSTERONE 17BETA-ACETATE
  • 17-hydroxy-19-nor-17a-4-pregnen-20-yn-3-one acetate
  • 17-HYDROXY-19-NOR-17ALPHA-4-PREGNEN-20-YN-3-ONE ACETATE
  • Norethisterone acetate for system suitability
  • NORETHINDRONE ACETATE
  • NORETHISTERONE ACETATE
  • acetic acid (17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl) ester
  • 17-acetyloxy(17-alpha)-19-norpregn-4-estren-17-beta-ol-acetate-3-one
  • 17-Acetyloxy(17alpha)-19-norpregn-4-estren-17beta-ol-acetate-3-one
  • 17alpha-Ethinyl-19-nortestosterone 17beta-acetate
  • 17alpha-Ethinyl-19-nortestosterone acetate
  • 17-alpha-ethinyl-19-nortestosterone-17-beta-acetate
  • 17-alpha-ethinyl-19-nortestosteroneacetate
  • 17-alpha-ethynyl-17-beta-acetoxy-19-norandrost-4-en-3-one
  • 17alpha-Ethynyl-17beta-acetoxy-19-norandrost-4-en-3-one
  • 17alpha-Ethynyl-17-hydroxyestr-4-en-3-one acetate
  • 17-alpha-ethynyl-17-hydroxyestr-4-en-3-oneacetate
  • 17-beta-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one
  • 17beta-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one
  • 17beta-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one acetate
  • (17-alpha)-17-(Acetyloxy)-19-norpregn-4-en-20-yn-3-one
  • (17α)-17-(acetyloxy)-19-norpregn-4-en-20-yn-3-one
  • 17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-on
  • 17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one
  • 17-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one
  • 17-beta-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-oneacetate
  • 17beta-Hydroxy-19-norpregn-4-en-20-yn-3-one acetate
  • 17-Ent
  • 17-Ethynyl-3-oxoestr-4-en-17-yl acetate
  • 17-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one acetate
  • 17-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-oneacetate
  • 17-Acetyloxy-17-ethinylestr-4-en-3-one