Bis-Mal-Lysine-PEG4-acid

Product Name: Bis-Mal-Lysine-PEG4-acid
CAS No.: 1426164-52-4
Chemical Name: Bis-Mal-Lysine-PEG4-acid
Synonyms: Bis-Mal-Lysine-PEG4-acid;4,7,10,13-Tetraoxa-16,23-diazahexacosanoic acid, 26-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-18-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-17,24-dioxo-, (18S)-
CBNumber: CB93162887
Molecular Formula: C31H45N5O13
Formula Weight: 695.71
MOL File: 1426164-52-4.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M198145
Product name: Bis-Mal-Lysine-PEG4-acid
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

BroadPharm

Product number: BP-22616
Product name: Bis-Mal-Lysine-PEG4-acid
Purity: 98%
Packaging: 100mg
Price: $320
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1239
Product name: Bis-Mal-Lysine-PEG4-acid
Packaging: 100mg
Price: $623
Updated: 2021/12/16

BroadPharm

Product number: BP-22616
Product name: Bis-Mal-Lysine-PEG4-acid
Purity: 98%
Packaging: 250mg
Price: $690
Updated: 2021/12/16

BroadPharm

Product number: BP-22616
Product name: Bis-Mal-Lysine-PEG4-acid
Purity: 98%
Packaging: 500mg
Price: $980
Updated: 2021/12/16

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Bis-Mal-Lysine-PEG4-acid Chemical Properties,Usage,Production

Description

Bis-Mal-Lysine-PEG4-acid is a PEG linker with two maleimide groups which can react with thiols from pH ranges of 6.5 to 7.5 to from a thiolester bond. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.

Uses

Bis-Mal-Lysine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bis-Mal-Lysine-PEG4-acid Preparation Products And Raw materials

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View Lastest Price from Bis-Mal-Lysine-PEG4-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Bis-Mal-Lysine-PEG4-acid 1426164-52-4
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-03-27

1426164-52-4, Bis-Mal-Lysine-PEG4-acidRelated Search:

alpha, oMega-DisucciniMidyl hexaethylene glycol Mal-PEG5-acid Mal-PEG2-amine Mal-PEG3-NHS ester Mal-PEG6-COOH N-Succinimidyl 3-maleimidopropionate Mal-PEG4-NHS ester 3,4-Dibromo-Mal-PEG2-Amine Maleimido-Tri(Ethylene Glycol)-Propionic Acid Mal-PEG2-COOH N-[4-(-Carboxycyclohexylmethyl)]maleimide Mal-PEG4-Acid Mal-PEG2-NHS ester Bis-Mal-Lysine-PEG4-TFP ester Maleimide-PEG4-NHS Ester Maleimide-PEG2-NHS Ester 3-Maleimidopropionic acid Mal-PEG2-acid

Bis-Mal-Lysine-PEG4-acid

4,7,10,13-Tetraoxa-16,23-diazahexacosanoic acid, 26-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-18-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-17,24-dioxo-, (18S)-

1426164-52-4

C31H45N5O13