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Acacetin

Product Name
Acacetin
CAS No.
480-44-4
Chemical Name
Acacetin
Synonyms
Abietic;acacetine;5,7-dihydroxy-4’-methoxy-flavon;ACACETIN;LY 064233;NSC 76061;Linarisenin;LINARIGENIN;Acacetin-RM;ACACETIN hplc
CBNumber
CB9316535
Molecular Formula
C16H12O5
Formula Weight
284.26
MOL File
480-44-4.mol
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Acacetin Property

Melting point:
260-265 °C(lit.)
Boiling point:
346.76°C (rough estimate)
Density 
1.2160 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Very Slightly, Heated)
form 
Solid
pka
6.51±0.40(Predicted)
color 
Light Yellow to Green-Yellow to Dark Yellow
λmax
335nm(EtOH)(lit.)
Merck 
14,13
BRN 
277879
InChIKey
DANYIYRPLHHOCZ-UHFFFAOYSA-N
LogP
2.443 (est)
CAS DataBase Reference
480-44-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DJ3002000
F 
3-8-10
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89482
Product name
Acacetin
Purity
phyproof? Reference Substance
Packaging
20mg
Price
$146.4
Updated
2024/03/01
Sigma-Aldrich
Product number
49975
Product name
Acacetin
Purity
analytical standard
Packaging
10mg
Price
$247
Updated
2022/05/15
TCI Chemical
Product number
A3013
Product name
Acacetin
Purity
>98.0%(GC)
Packaging
25mg
Price
$173
Updated
2024/03/01
TCI Chemical
Product number
A3013
Product name
Acacetin
Purity
>98.0%(GC)
Packaging
100mg
Price
$344
Updated
2024/03/01
Cayman Chemical
Product number
20827
Product name
Acacetin
Purity
≥98%
Packaging
50mg
Price
$121
Updated
2024/03/01
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Acacetin Chemical Properties,Usage,Production

Description

Acacetin is an O-methylated flavone found in various plants. It is reported to demonstrate spasmolytic, antinociceptive, anti-inflammatory, and antioxidant activity in various research models.

Chemical Properties

Yellow Solid

Uses

VEGF expression inhibitor and tumor angiogenesis. A flavonoid with antiaggregatory activity in human blood.

Definition

ChEBI: A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 6497, 1990 DOI: 10.1016/S0040-4039(00)97100-4

General Description

Acacetin belongs to the category of naturally occurring plant pigments called flavonoids found in vascular plants. It was first reported to be extracted from the leaves of Robinia pseuducacia. It has been used as an active component of traditional Chinese medicine Xuelianhua.

Biochem/physiol Actions

Acacetin has been noted to exhibit anti-peroxidative, anti-inflammatory, and anti-plasmodial properties. It has been posited to prevent the proliferation of Hep G2 cells, thereby causing cell apoptosis and subsequent anti-cancer action. It has antiarrhythmic properties and can be used in the treatment of Atrial fibrillation.

Enzyme inhibitor

This naturally occurring flavone (FW = 286.27 g/mol; CAS 480-44-4), also known as 5,7-dihydroxy-4’-methoxyflavone and 7-O-methylapigenin, and systematically named as 5,7-dihydroxy-2-(4-methoxyphenyl)-chromen-4- one, from the black locust Robinia pseudoacacia is the aglycon of linarin and acaciin and is biosynthesized by apigenin 4'-O-methyltransferase from S-adenosyl-methionine and 5,7,4’-trihydroxyflavone (apigenin), yielding Sadenosylhomocysteine and acacetin. The chemical synthesis of acacetin was accomplished by Robert Robinson, who was awarded the 1947 Nobel Prize in Chemistry for his work on alkaloids and organic synthesis. Target(s): glutathione S-transferase; xanthine oxidase, Ki = 0.11 μM; CYP1A; CYP1B1; glutathione-disulfide reductase; DNA topoisomerase I; [myosin light-chain] kinase; and protein-tyrosine kinase, or non-specific protein-tyrosine kinase.

Acacetin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Acacetin manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Acacetin 480-44-4
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-10
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Acacetin 480-44-4
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥98%
Supply Ability
20tons
Release date
2024-01-05
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Acacetin 480-44-4
Price
US $725.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
20 tons
Release date
2022-10-20

480-44-4, AcacetinRelated Search:

CETYL PALMITATE 1-Hydroxyethylidene-1,1-diphosphonic acid Triclosan Solvent Red 43 p-Anisidine Chrysin p-Anisaldehyde Anisole (Trifluoromethoxy)benzene (E,E)-Farnesol 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE 5,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE 3,7,3',4'-TETRAMETHYLGOSSYPETIN QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE ARTEMISININ TAMARIXETIN KAEMPFEROL-3,7,4'-TRIMETHYL ETHER

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  • ACACETIN(METHYL-4'-APIGENIN)(RG)
  • ACACETIN WITH HPLC
  • 4'-O-Methylapigenin
  • 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • Linarisenin
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  • 5,7-DIHYDROXY-2-(4-METHOXYPHENOL)-1-BENZOPYRAN-4-ONE
  • 1-BENZOPYRAN-4-ONE,5,7-DIHYDROXY-2-(4-METHOXYPHENOL)-
  • 2-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
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  • Acacetin 480-44-4
  • large stock Acacetin 480-44-4
  • 7-hydroxy-2-(4-methoxyphenyl)-4-oxo-1-benzopyran-5-olate
  • Acacetin, >98%
  • LY 064233
  • NSC 76061
  • ACACETIN >= 97.0% (HPLC)
  • 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-on
  • 5,7-dihydroxy-4’-methoxy-flavon
  • 5,7-dioxy-4’-methoxyflavone
  • acacetine
  • 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen
  • Acacetin, 98%, From Acacia farnesiana (L.) Willd.
  • 4'-Methoxyapigenin
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)-
  • O sand and paxil
  • 4'-methoxy-5,7-dihydroxy flavone
  • Acacetin Powder
  • Acacetin (5,7-Dihydroxy-4'-methoxyflavone)
  • (2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
  • Acacetin(Methyl-4′-Apigenin)(AS)
  • Acacetin-RM
  • 480-44-4
  • Food Residue Analysis
  • Food & Beverage Standards
  • Chromatography
  • Analytical Chromatography Product Catalog
  • Analytical Standards
  • Miscellaneous Reagents
  • inhibitor
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Tri-substituted Flavones
  • Aromatics
  • Heterocycles