ChemicalBook > CAS DataBase List > 7-BROMO-4-CHLOROQUINOLINE

7-BROMO-4-CHLOROQUINOLINE

Product Name
7-BROMO-4-CHLOROQUINOLINE
CAS No.
75090-52-7
Chemical Name
7-BROMO-4-CHLOROQUINOLINE
Synonyms
BUTTPARK 89\09-07;4-Chloro-7-bromoquinoline;7-BROMO-4-CHLOROQUINOLINE;Quinoline, 7-bromo-4-chloro-;7-Bromo-4-chloroquinoline 98%;7-Bromo-4-chloro-1-azanaphthalene
CBNumber
CB9319394
Molecular Formula
C9H5BrClN
Formula Weight
242.5
MOL File
75090-52-7.mol
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7-BROMO-4-CHLOROQUINOLINE Property

Melting point:
105-106 °C
Boiling point:
314.6±22.0 °C(Predicted)
Density 
1.673±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
1.99±0.27(Predicted)
color 
Beige
InChI
InChI=1S/C9H5BrClN/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-5H
InChIKey
JJUTYYVZDKDLBC-UHFFFAOYSA-N
SMILES
N1C2C(=CC=C(Br)C=2)C(Cl)=CC=1
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Safety

Hazard Codes 
T
Risk Statements 
25-41
Safety Statements 
26-39-45
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BBO000274
Product name
7-Bromo-4-chloroquinoline
Purity
Aldrich
Packaging
1g
Price
$216
Updated
2025/07/31
TRC
Product number
B684818
Product name
7-Bromo-4-chloroquinoline
Packaging
2.5g
Price
$330
Updated
2021/12/16
AK Scientific
Product number
W8258
Product name
7-Bromo-4-chloroquinoline
Packaging
5g
Price
$316
Updated
2021/12/16
Matrix Scientific
Product number
072607
Product name
7-Bromo-4-chloroquinoline
Purity
95+%
Packaging
5g
Price
$357
Updated
2021/12/16
Apolloscientific
Product number
OR43544
Product name
7-Bromo-4-chloroquinoline
Purity
98%
Packaging
5g
Price
$376
Updated
2021/12/16
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7-BROMO-4-CHLOROQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Synthesis

82121-06-0

75090-52-7

General procedure for the synthesis of 4-chloro-7-bromoquinoline from 4-hydroxy-7-bromoquinoline: Phosphorus oxychloride (106.76 g, 696.28 mmol) was added in batches to a solution of dioxane (660 mL) containing 4-hydroxy-7-bromoquinoline (60 g, 267.8 mmol) at 30 °C. The reaction mixture was stirred at 100 °C for 40 min before confirming that 4-hydroxy-7-bromoquinoline had been completely converted to 4-chloro-7-bromoquinoline by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the reaction was quenched with water (200 mL) and subsequently extracted with ethyl acetate (200 mL x 2). The combined organic phases were washed with saturated sodium chloride solution (100 mL x 2) and dried with anhydrous sodium sulfate. After concentration under reduced pressure, the target compound 4-chloro-7-bromoquinoline (light yellow solid, 59 g, 81.77% yield) was obtained. It was analyzed by liquid chromatography-mass spectrometry (LC-MS, ESI), and the molecular ion peak m/z was 243.8 ([M+H]+).

References

[1] Patent: EP3293177, 2018, A1. Location in patent: Paragraph 0459; 0460
[2] Journal of the American Chemical Society, 1949, vol. 71, p. 3236
[3] Journal of the American Chemical Society, 1946, vol. 68, p. 113,115
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4918 - 4926
[5] Patent: WO2018/34918, 2018, A1. Location in patent: Page/Page column 71

7-BROMO-4-CHLOROQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-BROMO-4-CHLOROQUINOLINE Suppliers

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View Lastest Price from 7-BROMO-4-CHLOROQUINOLINE manufacturers

Career Henan Chemical Co
Product
7-BROMO-4-CHLOROQUINOLINE 75090-52-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-19

75090-52-7, 7-BROMO-4-CHLOROQUINOLINERelated Search:

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  • BUTTPARK 89\09-07
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