ChemicalBook > CAS DataBase List > Alizarin Complexone

Alizarin Complexone

Product Name
Alizarin Complexone
CAS No.
3952-78-1
Chemical Name
Alizarin Complexone
Synonyms
ALIZARIN COMPLEXON;ALIZARIN FLUORINE BLUE;ALC【Dotite】;nyl)methyl]-;cenyl)methyl)-;alizarinkomplexon;alizarinecomplexon;Alizarincompiexone;ALIZARIN COMPLEXONE;alizarinecomplexone
CBNumber
CB9321290
Molecular Formula
C19H15NO8
Formula Weight
385.32
MOL File
3952-78-1.mol
More
Less

Alizarin Complexone Property

Melting point:
~185 °C (dec.)
Boiling point:
511.79°C (rough estimate)
Density 
1.4951 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
2-8°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml
pka
1.71±0.10(Predicted)
form 
Fine Powder
color 
Brown
Water Solubility 
Slightly soluble (0.2 g/L)
BRN 
2190028
Stability:
Incompatible with strong oxidizing agents.
InChI
InChI=1S/C19H15NO8/c21-13(22)7-20(8-14(23)24)6-9-5-12-15(19(28)16(9)25)18(27)11-4-2-1-3-10(11)17(12)26/h1-5,25,28H,6-8H2,(H,21,22)(H,23,24)
InChIKey
PWIGYBONXWGOQE-UHFFFAOYSA-N
SMILES
C(O)(=O)CN(CC(O)=O)CC1=C(O)C(O)=C2C(=C1)C(=O)C1=C(C=CC=C1)C2=O
CAS DataBase Reference
3952-78-1(CAS DataBase Reference)
EPA Substance Registry System
Glycine, N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]- (3952-78-1)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
AH0585000
TSCA 
Yes
HS Code 
29225090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A3882
Product name
Alizarin-3-methyliminodiacetic acid
Packaging
1g
Price
$171
Updated
2024/03/01
Sigma-Aldrich
Product number
A3882
Product name
Alizarin-3-methyliminodiacetic acid
Packaging
5g
Price
$531
Updated
2024/03/01
TCI Chemical
Product number
A3227
Product name
Alizarin Complexone
Purity
>70.0%(HPLC)
Packaging
1g
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
A3227
Product name
Alizarin Complexone
Purity
>70.0%(HPLC)
Packaging
5g
Price
$132
Updated
2024/03/01
Alfa Aesar
Product number
A16699
Product name
Alizarin Complexone, may cont. up to 10% water
Packaging
1g
Price
$94.6
Updated
2024/03/01
More
Less

Alizarin Complexone Chemical Properties,Usage,Production

Description

Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions. It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae. It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC50 = 35 nM).

Chemical Properties

Brown-orange crystals, insoluble in water

Uses

Alizarin Complexone is used for the determination of fluorine and other anions. ATA is also a potent inhibitor of protein-nucleic acid interactions.

Uses

Alizarin-3-methyliminodiacetic acid has been used:

  • for live staining of mineralized bone matrix
  • to double-label the bone for dynamic bone histomorphometry at the femoral mid-diaphysis in the rat
  • as a label in histomorphometry of the tibial diaphysis to indicate new bone formation in the rat

Uses

Alizarin is the main ingredient for the manufacture of the madder lake pigments known to painters as Rose madder and Alizarin crimson. A notable use of alizarin in modern times is as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color. Alizarin Red is used in a biochemical assay to determine, quantitatively by colorimetry, the presence of calcific deposition by cells of an osteogenic lineage.

Definition

ChEBI: A dihydroxyanthraquinone compound in which the hydroxy groups are at C-1 and C-2 and which has a bis[(carboxymethyl)amino]methyl substituent at the 3-position.

General Description

Alizarin-3-methyliminodiacetic acid is used in the colorimetric detection of fluorine. It is a dye employed to stain mineralized bones of the preserved specimen from vertebrates.

Hazard

Anthraquinones are toxic by ingestion: vomiting, diarrhea, kidney and liver damage, and coma;
Deaths have been reported after children ingested Rhamnus berries;
Has antiretroviral activity;
An irritant;
Harmful by ingestion, inhalation, or skin absorption;
Toxic if swallowed.

Purification Methods

It is purified by suspending it in 0.1M NaOH (1g in 50mL), filtering the solution and extracting alizarin with 5 successive portions of CH2Cl2. Then add HCl dropwise to precipitate the reagent, stirring the solution in an ice bath. Filter the precipitate onto a glass filter, wash it with cold water and dry it in a vacuum desiccator over KOH [Ingman Talanta 20 135 1973, Beilstein 14 IV 931].

Mode of action

Alizarin (1,2-dihydroxyanthraquinone) could form deeply colored metal complexes. Their stability can be increased considerably when edta-derived substituents are attached to the alizarin frame as a commercially available product of this type, alizarin complexone (AC) is a very useful reagent for the spectrophotometric determination of metals. The high stability of such metal complexes is essentially based on the chelate formation at the tridentate complexone substituent. However, if the coordination is restricted to this substituent, the spectral properties of alizarin should not be affected by metal cations owing to the electronically insulating methylene group between the complexone substituent and the alizarine nucleus. Accordingly, the color change observed upon complexation of AC is a consequence of forming an additional bond from a phenolate of the alizarin ring system to the metal[1]. Due to AC's low solubility in water, it could be soluble in ethanol in experiments. A solution of AC is yellow and displays an absorption with λmax = 430 nm(e = 5200 M-1 cm-1). The luminescence spectrum consists of two bands at λmax = 476 nm and 629 nm.

References

[1] Horst Kunkely, Arnd Vogler. “Fluorescence of alizarin complexone and its metal complexes.” Inorganic Chemistry Communications 10 3 (2007): Pages 355-357.

Alizarin Complexone Preparation Products And Raw materials

Raw materials

Alizarin Iminodiacetic acid

Preparation Products

More
Less

Alizarin Complexone Suppliers

Americas 1 Austria 1 China 231 Europe 3 France 1 Germany 6 India 30 Japan 4 Poland 1 South Korea 1 Spain 1 Switzerland 3 Ukraine 2 United Kingdom 10 United States 33 Global 328
Suzhouhongxiong
Tel
18051745768 18051745768
Email
Suzhouhongxiong@163.com
Country
China
ProdList
60
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9371
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44733
Advantage
61
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376090521
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
954
Advantage
60
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
0-1502103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9347
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 1316706386
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41457
Advantage
60
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5874
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653713
Email
xingui2022@126.com
Country
China
ProdList
9981
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16684
Advantage
50
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
13096311329 028-88469284 616445927
Fax
028-88469284
Email
616445927@qq.com
Country
China
ProdList
2874
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Changsha Jing Kang New Material Technology Co., Ltd.
Tel
0731-85118349 18874718518
Fax
0731-85118349
Email
ma_haihong@sina.com
Country
China
ProdList
1595
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Beijing NuoqiYa Biotechnology Co., Ltd.
Tel
4000-819-385 010-62329685 13718666987
Fax
010-62340519
Country
China
ProdList
1971
Advantage
55
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q3252066219
Fax
QQ3382968513
Email
hailey@shsendpharm.com
Country
China
ProdList
3096
Advantage
55
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
Codow Chemical Co.,Ltd.
Tel
18620099427 18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
1751
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
VWR(Shanghai) Co., Ltd
Tel
400-821-8006
Fax
+86-21-58558801
Email
info_china@vwr.com
Country
China
ProdList
3040
Advantage
75
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
More
Less

View Lastest Price from Alizarin Complexone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Alizarin Complexone 3952-78-1
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20
Hebei Fengqiang Trading Co., LTD
Product
ALIZARIN COMPLEXONE 3952-78-1
Price
US $100.00/bag
Min. Order
1bag
Purity
99
Supply Ability
5000
Release date
2023-09-08
Guangzhou Sunton Biotechnology Co., Ltd.
Product
Alizarin Fluorine Blue/Alizarin-3-methyliminodiacetic acid 3952-78-1
Price
US $48.00-40.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200tons
Release date
2021-03-30

3952-78-1, Alizarin Complexone Related Search:

Iminodiacetic acid Ethylenediaminetetraacetic acid disodium salt Folic acid Alizarin 1,2,5,8-TETRAHYDROXYANTHRAQUINONE Nitrilotriacetic acid Glycine Trypan Blue ACID ALIZARIN VIOLET N Ethyl 2-(Chlorosulfonyl)acetate 4-Aminophenylacetic acid 1.10-Phenanthroline Alizarin Red S Protocatechualdehyde 2-Hydroxybenzylamine Catechol 2,4-Dimethylphenol 3'-Methylacetophenone

  • (((3,4-dihydroxy-2-anthraquinonyl)methyl)imino)di-aceticaci
  • [(3,4-Dihydroxy-2-anthraquinonyl)methyl]iminod
  • 1,2-dihydroxy-anthrachinon-3-methylen-iminodiessigsaeure
  • Alizarin Fluorine Blue test solution(ChP)
  • 2-[carboxymethyl-[(3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]amino]acetic acid
  • ALIZARIN COMPLEXONE
  • Aizarin-3-methylamine-N,N-diaceticacid
  • Alizarincompiexone
  • alizarinecomplexon
  • alizarinecomplexone
  • alizarinecomplexonedihydrate
  • alizarinefluorineblue
  • Alizarinfluorinbiue
  • alizarinkomplexon
  • cenyl)methyl)-
  • glycine,n-(carboxymethyl)-n-((9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthra
  • glycine,n-(carboxymethyl)-n-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthrace
  • N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]-Glycine
  • 3,4-DIHYDROXYANTHRAQUINON-2-YL-METHYLIMINO-DIACETIC ACID
  • 3-AMINOMETHYLALIZARIN-N,N-DIACETIC ACID
  • ALIZARIN FLUORINE BLUE
  • ALIZARIN COMPLEXON
  • ALIZARIN-3-METHYLAMINE-N,N-DIACETIC ACID
  • ALIZARIN-3-METHYLIMINO-DIACETIC ACID
  • ALIZARIN-3-METHYLIMINO-N,N-DIACETIC ACID
  • nyl)methyl]-
  • 3-[n,n-bis(carboxymethyl)aminomethyl]-1,2-dihydroxyanthraquinone
  • 1,2-DIHYDROXYANTHRAQUINONYL-3-METHYLAMINE-N,N-DIACETIC ACID
  • LABOTEST-BB LT00159926
  • Alizarin-3-methyliminodiacetic acid,3,4-Dihydroxyanthraquinon-2-yl-methylimino-diacetic acid, Alizarin Complexone, Alizarin Fluorine Blue
  • Alizarin fluorin blue
  • Alizarin CoMplexone, May cont. up to 10% water
  • Alizarin-3-methylimino-N,N-diacetic Acid 1,2-Dihydroxyanthraquinonyl-3-methylamine-N,N-diacetic Acid
  • Alizarin fluorine flue
  • 2,2'-(((3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)Methyl)azanediyl)diacetic acid
  • Alizarin Complexone, may contain up to 10% water
  • 3,4-Dihydroxyanthraquinon-2-yl-methylimino-diacetic acid, Alizarin Fluorine Blue, Alizarin-3-methylamine-N,N-diacetic acid, Alizarin-3-methyliminodiacetic acid, (3,4-Dihydroxy-2-anthraquinonyl)methyliminodiacetic acid dihydrate
  • Alizarin Complexone(R) dihydrate
  • 3,4-Dihydroxyanthraquinon-2-yl-methylimino-diacetic acid, Alizarin Complexone(R), Alizarin Fluorine Blue
  • 2-[Carboxymethyl-[(3,4-dihydroxy-9,10-dioxoanthracen-2-yl)methyl]amino]acetic acid
  • 3-[Bis(carboxymethyl)aminomethyl]-1,2-dihydroxy-9,10-anthraquinone
  • ALC【Dotite】
  • (3,4-Dihydroxy-2-anthraquinonyl)methyliminodiacetic acid
  • dihydrate Alizarin fluorine
  • ALIZARIN COMPLEXONE DIHYDRATE, INDICATOR GRADE
  • 3-AMINOMETHYLALIZARIN-N,N-DIACETIC ACID DIHYDRATE R.G.FOR SPECTROPHOTO.DETERM.OF
  • AlizarineComplexone-(Alizarin-3-MethylIminodiaceticAcid)MetalIndicator
  • AlizarinComplexonDihydrate,IndicatorGrade
  • ALIZARIN COMPLEXONE GR
  • ALIZARIN FLUORINE BLUE 2-HYDRATE
  • ALIZARIN COMPLEXONE 2-HYDRATE
  • 3-(Aminomethyl)alizarindiacetic acid
  • 3-Alizarinmethylamine-N,N-diacetic acid
  • Alizarin complexone;3-Alizarinmethylamine-N,N-diacetic acid;Alizarin fluorine blue;3-(Aminomethyl)alizarindiacetic acid
  • 3-[N,N-Bis(carboxymethyl)aminomethyl]-1,2-dihydroxyanthraquinone (ALC)
  • Alizarin-3-methyliminodiacetic acid,IND
  • Glycine, N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]-
  • Alizarin Fluorine Blue/Alizarin-3-methyliminodiacetic acid