Alizarin Complexone

Product Name: Alizarin Complexone
CAS No.: 3952-78-1
Chemical Name: Alizarin Complexone
Synonyms: ALIZARIN COMPLEXON;ALIZARIN FLUORINE BLUE;ALC【Dotite】;nyl)methyl]-;cenyl)methyl)-;alizarinkomplexon;alizarinecomplexon;Alizarincompiexone;ALIZARIN COMPLEXONE;alizarinecomplexone
CBNumber: CB9321290
Molecular Formula: C19H15NO8
Formula Weight: 385.32
MOL File: 3952-78-1.mol

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Alizarin Complexone Property

Melting point:: ~185 °C (dec.)
Boiling point:: 511.79°C (rough estimate)
Density: 1.4951 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml
pka: 1.71±0.10(Predicted)
form: Fine Powder
color: Brown
Water Solubility: Slightly soluble (0.2 g/L)
BRN: 2190028
Stability:: Incompatible with strong oxidizing agents.
InChI: InChI=1S/C19H15NO8/c21-13(22)7-20(8-14(23)24)6-9-5-12-15(19(28)16(9)25)18(27)11-4-2-1-3-10(11)17(12)26/h1-5,25,28H,6-8H2,(H,21,22)(H,23,24)
InChIKey: PWIGYBONXWGOQE-UHFFFAOYSA-N
SMILES: C(O)(=O)CN(CC(O)=O)CC1=C(O)C(O)=C2C(=C1)C(=O)C1=C(C=CC=C1)C2=O
CAS DataBase Reference: 3952-78-1(CAS DataBase Reference)
EPA Substance Registry System: Glycine, N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]- (3952-78-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
RTECS: AH0585000
TSCA: Yes
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3882
Product name: Alizarin-3-methyliminodiacetic acid
Packaging: 1g
Price: $171
Updated: 2024/03/01

Sigma-Aldrich

Product number: A3882
Product name: Alizarin-3-methyliminodiacetic acid
Packaging: 5g
Price: $531
Updated: 2024/03/01

TCI Chemical

Product number: A3227
Product name: Alizarin Complexone
Purity: >70.0%(HPLC)
Packaging: 1g
Price: $44
Updated: 2024/03/01

TCI Chemical

Product number: A3227
Product name: Alizarin Complexone
Purity: >70.0%(HPLC)
Packaging: 5g
Price: $132
Updated: 2024/03/01

Alfa Aesar

Product number: A16699
Product name: Alizarin Complexone, may cont. up to 10% water
Packaging: 1g
Price: $94.6
Updated: 2024/03/01

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Alizarin Complexone Chemical Properties,Usage,Production

Description

Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions. It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae. It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC₅₀ = 35 nM).

Chemical Properties

Brown-orange crystals, insoluble in water

Uses

Alizarin Complexone is used for the determination of fluorine and other anions. ATA is also a potent inhibitor of protein-nucleic acid interactions.

Uses

Alizarin-3-methyliminodiacetic acid has been used:

for live staining of mineralized bone matrix
to double-label the bone for dynamic bone histomorphometry at the femoral mid-diaphysis in the rat
as a label in histomorphometry of the tibial diaphysis to indicate new bone formation in the rat

Uses

Alizarin is the main ingredient for the manufacture of the madder lake pigments known to painters as Rose madder and Alizarin crimson. A notable use of alizarin in modern times is as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color. Alizarin Red is used in a biochemical assay to determine, quantitatively by colorimetry, the presence of calcific deposition by cells of an osteogenic lineage.

Definition

ChEBI: A dihydroxyanthraquinone compound in which the hydroxy groups are at C-1 and C-2 and which has a bis[(carboxymethyl)amino]methyl substituent at the 3-position.

General Description

Alizarin-3-methyliminodiacetic acid is used in the colorimetric detection of fluorine. It is a dye employed to stain mineralized bones of the preserved specimen from vertebrates.

Hazard

Anthraquinones are toxic by ingestion: vomiting, diarrhea, kidney and liver damage, and coma;
Deaths have been reported after children ingested Rhamnus berries;
Has antiretroviral activity;
An irritant;
Harmful by ingestion, inhalation, or skin absorption;
Toxic if swallowed.

Purification Methods

It is purified by suspending it in 0.1M NaOH (1g in 50mL), filtering the solution and extracting alizarin with 5 successive portions of CH2Cl2. Then add HCl dropwise to precipitate the reagent, stirring the solution in an ice bath. Filter the precipitate onto a glass filter, wash it with cold water and dry it in a vacuum desiccator over KOH [Ingman Talanta 20 135 1973, Beilstein 14 IV 931].

Mode of action

Alizarin (1,2-dihydroxyanthraquinone) could form deeply colored metal complexes. Their stability can be increased considerably when edta-derived substituents are attached to the alizarin frame as a commercially available product of this type, alizarin complexone (AC) is a very useful reagent for the spectrophotometric determination of metals. The high stability of such metal complexes is essentially based on the chelate formation at the tridentate complexone substituent. However, if the coordination is restricted to this substituent, the spectral properties of alizarin should not be affected by metal cations owing to the electronically insulating methylene group between the complexone substituent and the alizarine nucleus. Accordingly, the color change observed upon complexation of AC is a consequence of forming an additional bond from a phenolate of the alizarin ring system to the metal[1]. Due to AC's low solubility in water, it could be soluble in ethanol in experiments. A solution of AC is yellow and displays an absorption with λmax = 430 nm(e = 5200 M^-1 cm^-1). The luminescence spectrum consists of two bands at λmax = 476 nm and 629 nm.

References

[1] Horst Kunkely, Arnd Vogler. “Fluorescence of alizarin complexone and its metal complexes.” Inorganic Chemistry Communications 10 3 (2007): Pages 355-357.

Alizarin Complexone Preparation Products And Raw materials

Raw materials

Alizarin Iminodiacetic acid

Preparation Products

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Alizarin Complexone Suppliers

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View Lastest Price from Alizarin Complexone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Alizarin Complexone 3952-78-1
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

Hebei Fengqiang Trading Co., LTD

Product: ALIZARIN COMPLEXONE 3952-78-1
Price: US $100.00/bag
Min. Order: 1bag
Purity: 99
Supply Ability: 5000
Release date: 2023-09-08

Guangzhou Sunton Biotechnology Co., Ltd.

Product: Alizarin Fluorine Blue/Alizarin-3-methyliminodiacetic acid 3952-78-1
Price: US $48.00-40.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200tons
Release date: 2021-03-30

3952-78-1, Alizarin Complexone Related Search:

Iminodiacetic acid Ethylenediaminetetraacetic acid disodium salt Folic acid Alizarin 1,2,5,8-TETRAHYDROXYANTHRAQUINONE Nitrilotriacetic acid Glycine Trypan Blue ACID ALIZARIN VIOLET N Ethyl 2-(Chlorosulfonyl)acetate 4-Aminophenylacetic acid 1.10-Phenanthroline Alizarin Red S Protocatechualdehyde 2-Hydroxybenzylamine Catechol 2,4-Dimethylphenol 3'-Methylacetophenone

(((3,4-dihydroxy-2-anthraquinonyl)methyl)imino)di-aceticaci

[(3,4-Dihydroxy-2-anthraquinonyl)methyl]iminod

1,2-dihydroxy-anthrachinon-3-methylen-iminodiessigsaeure

Alizarin Fluorine Blue test solution(ChP)

2-[carboxymethyl-[(3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]amino]acetic acid

ALIZARIN COMPLEXONE

Aizarin-3-methylamine-N,N-diaceticacid

Alizarincompiexone

alizarinecomplexon

alizarinecomplexone

alizarinecomplexonedihydrate

alizarinefluorineblue

Alizarinfluorinbiue

alizarinkomplexon

cenyl)methyl)-

glycine,n-(carboxymethyl)-n-((9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthra

glycine,n-(carboxymethyl)-n-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthrace

N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]-Glycine

3,4-DIHYDROXYANTHRAQUINON-2-YL-METHYLIMINO-DIACETIC ACID

3-AMINOMETHYLALIZARIN-N,N-DIACETIC ACID

ALIZARIN FLUORINE BLUE

ALIZARIN COMPLEXON

ALIZARIN-3-METHYLAMINE-N,N-DIACETIC ACID

ALIZARIN-3-METHYLIMINO-DIACETIC ACID

ALIZARIN-3-METHYLIMINO-N,N-DIACETIC ACID

nyl)methyl]-

3-[n,n-bis(carboxymethyl)aminomethyl]-1,2-dihydroxyanthraquinone

1,2-DIHYDROXYANTHRAQUINONYL-3-METHYLAMINE-N,N-DIACETIC ACID

LABOTEST-BB LT00159926

Alizarin-3-methyliminodiacetic acid,3,4-Dihydroxyanthraquinon-2-yl-methylimino-diacetic acid, Alizarin Complexone, Alizarin Fluorine Blue

Alizarin fluorin blue

Alizarin CoMplexone, May cont. up to 10% water

Alizarin-3-methylimino-N,N-diacetic Acid 1,2-Dihydroxyanthraquinonyl-3-methylamine-N,N-diacetic Acid

Alizarin fluorine flue

2,2'-(((3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)Methyl)azanediyl)diacetic acid

Alizarin Complexone, may contain up to 10% water

3,4-Dihydroxyanthraquinon-2-yl-methylimino-diacetic acid, Alizarin Fluorine Blue, Alizarin-3-methylamine-N,N-diacetic acid, Alizarin-3-methyliminodiacetic acid, (3,4-Dihydroxy-2-anthraquinonyl)methyliminodiacetic acid dihydrate

Alizarin Complexone(R) dihydrate

3,4-Dihydroxyanthraquinon-2-yl-methylimino-diacetic acid, Alizarin Complexone(R), Alizarin Fluorine Blue

2-[Carboxymethyl-[(3,4-dihydroxy-9,10-dioxoanthracen-2-yl)methyl]amino]acetic acid

3-[Bis(carboxymethyl)aminomethyl]-1,2-dihydroxy-9,10-anthraquinone

ALC【Dotite】

(3,4-Dihydroxy-2-anthraquinonyl)methyliminodiacetic acid

dihydrate Alizarin fluorine

ALIZARIN COMPLEXONE DIHYDRATE, INDICATOR GRADE

3-AMINOMETHYLALIZARIN-N,N-DIACETIC ACID DIHYDRATE R.G.FOR SPECTROPHOTO.DETERM.OF

AlizarineComplexone-(Alizarin-3-MethylIminodiaceticAcid)MetalIndicator

AlizarinComplexonDihydrate,IndicatorGrade

ALIZARIN COMPLEXONE GR

ALIZARIN FLUORINE BLUE 2-HYDRATE

ALIZARIN COMPLEXONE 2-HYDRATE

3-(Aminomethyl)alizarindiacetic acid

3-Alizarinmethylamine-N,N-diacetic acid

Alizarin complexone;3-Alizarinmethylamine-N,N-diacetic acid;Alizarin fluorine blue;3-(Aminomethyl)alizarindiacetic acid

3-[N,N-Bis(carboxymethyl)aminomethyl]-1,2-dihydroxyanthraquinone (ALC)

Alizarin-3-methyliminodiacetic acid,IND

Glycine, N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]-

Alizarin Fluorine Blue/Alizarin-3-methyliminodiacetic acid