ChemicalBook > CAS DataBase List > AZD0364

AZD0364

Product Name
AZD0364
CAS No.
2097416-76-5
Chemical Name
AZD0364
Synonyms
CS-2696;AZD0364;ADZ0346;Tizaterkib;ERK2 inhibitor;AZD0364 (ATG-017);AZD-0364/Tizaterkib;AZD 0364;AZD0364;ERK2 INHIBITOR;inhibit,ERK,AZD0364,AZD 0364,Tizaterkib,Inhibitor,Extracellular signal regulated kinases;(R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one
CBNumber
CB93379847
Molecular Formula
C24H24F2N8O2
Formula Weight
494.5
MOL File
2097416-76-5.mol
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AZD0364 Property

Boiling point:
716.0±70.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:41.67(Max Conc. mg/mL);84.27(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);50.56(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM)
Ethanol:54.5(Max Conc. mg/mL);110.21(Max Conc. mM)
form 
A crystalline solid
pka
2?+-.0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29827
Product name
AZD 0364
Packaging
1mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
29827
Product name
AZD 0364
Packaging
10mg
Price
$672
Updated
2024/03/01
Cayman Chemical
Product number
29827
Product name
AZD 0364
Packaging
5mg
Price
$410
Updated
2024/03/01
ChemScene
Product number
CS-0042190
Product name
AZD-0364
Purity
99.75%
Packaging
10mg
Price
$480
Updated
2021/12/16
Apolloscientific
Product number
BISN0049
Product name
AZD0364
Purity
98%
Packaging
10mg
Price
$617
Updated
2021/12/16
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AZD0364 Chemical Properties,Usage,Production

Biological Activity

AZD0364 (ATG-017) is an ERK1/2 inhibitor with IC50 of 0.6 nM for ERK2.

in vitro

AZD0364 has high cellular activity against direct downstream substrates of the MAPK signaling pathway (as in BRAF.

in vivo

AZD0364 has good oral pharmacokinetics in various species. In a xenograft model, AZD0364 inhibited phosphorylated p90RSK1 in a concentration-dependent manner in tumors. AZD0634 induces tumor regression in a KRAS-mutated NSCLC Calu 6 xenograft model, in which AZD0634 can be safely and effectively administered in combination with selumetinib.

target

TargetValue
ERK2
()		 0.6 nM

AZD0364 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD0364 Suppliers

China 50 India 1 United States 6 Global 57
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2097416-76-5, AZD0364Related Search:

AZD-5672 CCR1 antagonist AZD-7648 AZD5153 AZD-8055 AZD-0284 AZD-5305 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156

  • AZD0364
  • CS-2696
  • AZD 0364;AZD0364;ERK2 INHIBITOR
  • ERK2 inhibitor
  • ADZ0346
  • Imidazo[1,2-a]pyrazin-8(5H)-one, 7-[(3,4-difluorophenyl)methyl]-6,7-dihydro-6-(methoxymethyl)-2-[5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-, (6R)-
  • Tizaterkib
  • AZD-0364/Tizaterkib
  • AZD0364 (ATG-017)
  • inhibit,ERK,AZD0364,AZD 0364,Tizaterkib,Inhibitor,Extracellular signal regulated kinases
  • (R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one
  • 2097416-76-5
  • C24H24F2N8O2
  • API