Description Uses Toxicity
ChemicalBook > CAS DataBase List > Dextran Sulfate Sodium Salt

Dextran Sulfate Sodium Salt

Description Uses Toxicity
Product Name
Dextran Sulfate Sodium Salt
CAS No.
9011-18-1
Chemical Name
Dextran Sulfate Sodium Salt
Synonyms
DEXTRAN SULFATE SODIUM;DEXTRAN SULFATE;SODIUM DEXTRAN SULFATE;DEXTRAN SULPHATE SODIUM;SODIUM DEXTRAN SULFATE 5000;Dextran sulfate sodium salt - MW 9,000-11,000 - from Leuconostoc spp;asuro;dexnon;ds-m-1;DEXTRAN SULPHATE
CBNumber
CB9339022
Molecular Formula
(C6H7Na3O14S3)n
Formula Weight
0
MOL File
Mol file
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Dextran Sulfate Sodium Salt Property

storage temp. 
room temp
solubility 
H2O: 100 mg/mL
form 
powder
color 
White to off-white
PH
pH(50g/l, 25℃）4.5～8.0
Water Solubility 
Soluble in water.
Merck 
2951
InChI
InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3
InChIKey
BLFLLBZGZJTVJG-UHFFFAOYSA-N
SMILES
C(OCC)(=O)C1=CC=C(N)C=C1
EPA Substance Registry System
Dextran, hydrogen sulfate, sodium salt (9011-18-1)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-37/39-24/25
WGK Germany 
2
RTECS 
HH9290000
F 
3-10
TSCA 
Yes
HS Code 
39139000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4031
Product name
Dextran Sulfate 50% Solution
Packaging
200ML
Price
$369
Updated
2024/03/01
Sigma-Aldrich
Product number
31404
Product name
Dextran sulfate sodium salt from Leuconostoc spp.
Purity
Mr 5,000
Packaging
5G
Price
$61.1
Updated
2024/03/01
Sigma-Aldrich
Product number
31404
Product name
Dextran sulfate sodium salt from Leuconostoc spp.
Purity
Mr 5,000
Packaging
25g
Price
$292
Updated
2024/03/01
Sigma-Aldrich
Product number
265152-M
Product name
Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem
Purity
Used to accelerate hybridization of DNA probes to immobilized nucleic acids.
Packaging
265152-10GM
Price
$95.8
Updated
2024/03/01
Sigma-Aldrich
Product number
265152-M
Product name
Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem
Purity
Used to accelerate hybridization of DNA probes to immobilized nucleic acids.
Packaging
265152-50GM
Price
$318
Updated
2024/03/01
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Dextran Sulfate Sodium Salt Chemical Properties,Usage,Production

Description

Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity.
With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared.
Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis.
Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects.

  • Enzyme inhibition, activation and release
  • Adjuvant effect on immune response
  • Cellular interactions and response
  • Effect on virus infectivity

Uses

  1. Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
  2. Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
  3. Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.

Toxicity

The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy.
More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative.

Chemical Properties

White to off-white powder

Uses

Clinical reagent (HDL cholesterol determination).

Uses

Clinical studies indicate a possible capacity of dextran sulfate to reduce edema. It is cited as a binder and skin conditioner.

Uses

Dextran sulfate sodium salt Leuconostoc spp has been used:

  • as a standard to perform polyacrylamide-gel electrophoresis for carbohydrates (C-PAGE)(59) and agarose gel electrophoresis(60)
  • for RNA sequential probing of targets (SPOTs) imaging(61)
  • as a component of 1% injection buffer(62)

Definition

ChEBI: Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. It has a role as a topical anaesthetic, an antipruritic drug, an allergen and a sensitiser. It is a benzoate ester and a substituted aniline.

General Description

Dextran sulfate is a sulfated polysaccharide, which is negatively charged. It is produced by the esterification of dextran with chlorosulphonic acid. Dextran is used to treat hemorrhage, burns, surgery and trauma. It improves blood flow and prevents erythrocyte aggregation. Dextran lowers the risk of thrombosis and postoperative pulmonary emboli. It is a ribonuclease inhibitor. Dextran sulfate exhibits antiviral, anticoagulant and adjuvant properties.

Biochem/physiol Actions

Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength. The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.

Dextran Sulfate Sodium Salt Preparation Products And Raw materials

Raw materials

Esterified product Dextran Pyridine sulfur trioxide

Preparation Products

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View Lastest Price from Dextran Sulfate Sodium Salt manufacturers

Watson Biotechnology Co.,Ltd
Product
Dextran sulfate sodium salt 9011-18-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-12-23
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Dextran Sulfate Sodium Salt 9011-18-1
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-23
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Dextran Sulfate Sodium Salt 9011-18-1
Price
US $99.00-66.00/kg
Min. Order
0.0010000000474974513kg
Purity
99%
Supply Ability
5000
Release date
2024-08-19

9011-18-1, Dextran Sulfate Sodium SaltRelated Search:

Sodium sulfate SEPHADEX G-10 Ferrous sulfate monohydrate Polysucrose Dextran SEPHADEX G-50 YEAST BETA-GLUCAN Ammonium sulfate Potassium sulfate DEXTRANASE SP SEPHADEX Dextran blue 2000 calcium sulfate Heparitin, sulfate sulfate TERT-BUTYL ISOCYANIDE METHYL ISOCYANOACETATE Benzyl isocyanide Dextran Sulphate Dextran Sulphate Sodium Salt

  • asuro
  • dexnon
  • Dextran sulfate sodium salt, M.W 5,000
  • Dextran sulfate sodium salt, M.W 6,500-10,000
  • OmniPur Dextran Sulfate Sodium - CAS 9011-18-1 - Calbiochem
  • Dextran sulfate sodium salt,Mw 40,000
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  • Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem
  • Dextran sulphate sodium salt 15,000
  • Dextran sulphate 500000
  • Dextran sulfate sodium salt - MW 100,000
  • Dextran sulfate sodium salt - MW 4500-5500
  • Dextran sulfate sodium salt - MW 6,000-10,000
  • Dextran sulfate sodium salt - MW 9,000-11,000 - from Leuconostoc spp
  • Dextran,hydrogensulfate,sodiumsalt
  • dextransodiumsulfate
  • dextransulfateso-saltfromleuconostocssp.
  • dextrarine
  • dexulate
  • ds-m-1
  • mds(polysaccharide)
  • DEXTRAN SULFATE SODIUM MOLECULAR*BIOLOGY REAGENT
  • DEXTRAN SULFATE SODIUM SALT, FROM LEUCONOSTOC SSP.
  • DEXTRAN SULFATE SODIUM AV. MOL. WT. OF*5 00,000
  • DEXTRAN SULFATE SO-SALT FROM LEUCONOSTOC SSP., MR ~500000
  • DEXTRAN SULFATE SODIUM SALT FROM LEUCONOSTOC SSP., MW 100'000
  • DEXTRAN SULFATE SODIUM SALT FROM LEUCONOSTOC SPP.
  • DEXTRAN SULFATE SODIUM AV. MOL. WT.*APPR OX. 8,000
  • DextranSulfate500,000Mw
  • DEXTRANSULFATE,50%SOLUTION,STERILE,BIOTECHGRADE
  • DEXTRANSULFATESODIUMSALT,POWDER
  • DEXTRANSULFATESODIUMSALT,POWDER,HEAVY
  • DEXTRANSULFATESODIUMSALT,POWDER,LIGHT
  • extran sulfate sodium
  • DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 2.500)
  • DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 4.000)
  • DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 25.000)
  • Dextran Sulfate 2000
  • Dextran Sulfate 3000
  • Dextran Sulfate 40,000
  • Dextran Sulfate 50,000
  • Dextran sulfate 500,000
  • Dextran Sulfate 5000
  • DEXTRAN SULPHATE extrapure
  • DEXTRAN SULFATE AV. MOL. WT. 5,000*(LALL S)
  • Dextran sulphate sodium from leuconostoc 500,000
  • Dextran Sulfate 10,000
  • Dextran sulfate sodium salt from Dextran of Mw. Approx. 15,000
  • Dextran sulfate sodium salt from Dextran of Mw. Approx. 10,000
  • Dextran sulfate sodium salt from Dextran of Mw. Approx. 1,500
  • Isomalto oligosaccharide sulfate1500
  • Isomalto oligosaccharide sulfate3000
  • Dextran sulfate sodium from Dextran of Mw. Approx. 10,000
  • Dextran sulfate sodium from Dextran of Mw. Approx. 15,000
  • Dextran sulfate sodium from Dextran of Mw. Approx. 20,000
  • Dextran sulfate sodium from Dextran of Mw. Approx. 40,000
  • Dextran sulfate sodium from Dextran of Mw. Approx. 50,000
  • ACRYL/BIS 19:1 ULTRA PURE GRADE