ChemicalBook > CAS DataBase List > Protopine

Protopine

Product Name
Protopine
CAS No.
130-86-9
Chemical Name
Protopine
Synonyms
BIFLORIN;Protopin;PROTOPINE;Biflorine;Corydinine;Tangeratin;Hypercorine;AKOS 243-72;Corydalis C;Protopine USP/EP/BP
CBNumber
CB9347526
Molecular Formula
C20H19NO5
Formula Weight
353.37
MOL File
130-86-9.mol
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Protopine Property

Melting point:
203-205?C
Boiling point:
486.8°C (rough estimate)
Density 
1.399 (calc)
refractive index 
1.5800 (estimate)
storage temp. 
Inert atmosphere,2-8°C
Water Solubility 
Insoluble in water
solubility 
DMSO : 12.5 mg/mL (35.37 mM; Need ultrasonic)
pka
7.86±0.20(Predicted)
form 
powder to crystal
color 
White to Light gray to Light yellow
LogP
3.760 (est)
NIST Chemistry Reference
Protopine(130-86-9)
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Safety

Safety Statements 
24/25
RIDADR 
1544
RTECS 
VS2800000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29391900
Hazardous Substances Data
130-86-9(Hazardous Substances Data)
Toxicity
guinea pig,LD50,intraperitoneal,116mg/kg (116mg/kg),Therapie. Vol. 28, Pg. 767, 1973.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89546
Product name
Protopine
Purity
phyproof? Reference Substance
Packaging
10mg
Price
$425
Updated
2024/03/01
TCI Chemical
Product number
P2611
Product name
Protopine
Purity
>98.0%(GC)
Packaging
5mg
Price
$45
Updated
2024/03/01
TCI Chemical
Product number
P2611
Product name
Protopine
Purity
>98.0%(GC)
Packaging
25mg
Price
$130
Updated
2024/03/01
TCI Chemical
Product number
P2611
Product name
Protopine
Purity
>98.0%(GC)
Packaging
100mg
Price
$355
Updated
2024/03/01
Usbiological
Product number
300834
Product name
Protopine
Packaging
20mg
Price
$320
Updated
2021/12/16
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Protopine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Protopine is a Ca2+ channel blocker and antiplatelet agent. Immunomodulator

Definition

ChEBI: A dibenzazecine alkaloid isolated from Fumaria vaillantii.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Purification Methods

It crystallises from EtOH/CHCl3. The picrate has m ~240o(dec). [Beilstein 27 H 558, 17 I 568, 17 II 620, 17 III/IV 6881.]

Protopine Preparation Products And Raw materials

Raw materials

Preparation Products

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Protopine Suppliers

Canada 1 China 154 Czech 1 France 2 Germany 1 India 3 Japan 1 United Kingdom 4 United States 18 Global 185
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View Lastest Price from Protopine manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Protopine 130-86-9
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-25
Career Henan Chemical Co
Product
Protopine 130-86-9
Price
US $9.80/KG
Min. Order
1g
Purity
＞98%
Supply Ability
20 tons
Release date
2020-02-10

130-86-9, ProtopineRelated Search:

Methyl acetate Pirimiphos-methyl Kresoxim-methyl Tribenuron methyl METSULFURON METHYL Methyl salicylate Thiophanate-methyl Protoporphyrin IX Methyl Methyl bromide PROTOPINE HCL,PROTOPINE HYDROCHLORIDE NSC26657 DESOXYANISOIN 3-METHOXYPHENYLACETONE CORYCAVINE PIPERONYL METHYL KETONE 3'-methoxypropiophenone [2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-AMINE

  • 7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-
  • 7-Methyl-6,8,9,16-tetrahydrodi[1,3]benzodioxolo[4,5-c:5,6-g]azecin-15(7H)-one
  • Biflorine
  • Bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-
  • Corydinine
  • Hypercorine
  • Protopin
  • BIFLORIN
  • AKOS 243-72
  • 5,7-DIHYDROXY-2-METHYLCHROMONE-6-C-BETA-D-GLUCOPYRANOSIDE
  • PROTOPINE
  • 4,6,7,14-Tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c-5',6'-g] azecin-13(5H)-one
  • 7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one
  • 5-Methyl-9,10-(methylenedioxy)-4,6,7,13-tetrahydrobenzo[e]-1,3-dioxolo[4,5-l][2]benzazecine-12(5H)-one
  • 6-Methyl-3,4-(methylenebisoxy)-10,11-(methylenebisoxy)-5,6,7,8-tetrahydrodibenzo[c,g]azecine-13(14H)-one
  • 7-Methyl-6,7,8,9-tetrahydro-[1,3]dioxolo[4',5':5,6]benzo[1,2-c][1,3]dioxolo[5',4':4,5]benzo[1,2-g]azecin-15(16H)-one
  • 4,6,7,14-Tetrahydro-5-Methyl-
  • Tangeratin
  • Corydalis C
  • Protopine (Corydinine)
  • Protopine, 98%, from Corydalis yanhusuo W. T. Wang ex Z. Y. Su et C. Y. Wu
  • Protopine USP/EP/BP
  • 1H-Isoindole-1,3(2H)-dione,2-(3-butyn-2-yl)-
  • 130-86-9
  • C20H19O5
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals