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BRAZILIN

Product Name
BRAZILIN
CAS No.
474-07-7
Chemical Name
BRAZILIN
Synonyms
razilin;BRAZILIN;CI 75280;brasilin;NSC 56652;braziletto;Brazilin-RM;(+)-Brazilin;Brazilin(6CI);superbresiline
CBNumber
CB9350126
Molecular Formula
C16H14O5
Formula Weight
286.28
MOL File
474-07-7.mol
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BRAZILIN Property

Melting point:
156-157℃
Boiling point:
348.65°C (rough estimate)
Density 
1.1924 (rough estimate)
refractive index 
1.6200 (estimate)
solubility 
DMSO:43.5(Max Conc. mg/mL);151.95(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);104.79(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);104.79(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);34.93(Max Conc. mM)
form 
A crystalline solid
color 
Yellow to brown
EPA Substance Registry System
Brazilin (474-07-7)
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Safety

Safety Statements 
24/25
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2132
Product name
Brazilin
Packaging
5MG
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2132
Product name
Brazilin
Packaging
25MG
Price
$246.6
Updated
2024/03/01
Cayman Chemical
Product number
22456
Product name
Brazilin
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22456
Product name
Brazilin
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
22456
Product name
Brazilin
Purity
≥98%
Packaging
10mg
Price
$230
Updated
2024/03/01
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BRAZILIN Chemical Properties,Usage,Production

Description

Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 μM) more potently than (-)-epigallocatechin gallate , cucurmin , and resveratrol (Item Nos. 10004235 | 70675). It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 and TNF-α (IC50s = 12.6 and 87.2 μM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 μg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.

Uses

Brazilin is a hair dyeing composition that comprises a natural dye and fatty amine.

Uses

Chiefly as a dye. Has also been recommended as indicator in acid-base titrations; acids = yellow, alkalies = carmine-red.

Uses

inhibits platelet aggregation, PLA2, PKC, protein phosphatase, insulin receptor kinase, nitric oxide synthase, antineoplastic

Definition

ChEBI: A organic heterotetracyclic compound that is a red pigment obtained from the wood of Caesalpinia echinata (Brazil-wood) or Caesalpinia sappan (sappan-wood).

Purification Methods

Brazilin crystallises from EtOH as yellow crystals which become orange when exposed to light and air, and is yellow in dilute acid but crimson in dilute alkali. When crystallised from H2O, it has m 247-248o. It forms coloured metal salts and is oxidized in air to Brazilein the quinonoid form. The (±)-form has been resolved, and the (+)-enantiomer has [] 20 +121o (c 1, MeOH). [Craig et al. J Org Chem 30 1573 1965,Morsingh & Robinson Tetrahedron 26 281 1970, Beilstein 17 H 194, 17 II 244, 17 III/IV 2711.]

BRAZILIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BRAZILIN Suppliers

China 161 Germany 1 India 2 United Kingdom 4 United States 18 Global 186
Central Drug House(P) Ltd.
Tel
--
Fax
--
Email
sales@cdhfinechemical.com
Country
India
ProdList
6157
Advantage
58
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View Lastest Price from BRAZILIN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
BRAZILIN 474-07-7
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-02
Shanghai Standard Technology Co., Ltd.
Product
Brazilin 474-07-7
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
BRAZILIN 474-07-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

474-07-7, BRAZILINRelated Search:

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  • 6a,9,10(6h)-tetrol,7,11b-dihydro-2-d]pyran-(6as-cis)-benz[b]indeno[
  • 7,11b-dihydrobenz(b)indeno(1,2-d)pyran-3,6a,9,10(6h)-tetrol
  • brasilin
  • braziletto
  • hypernicextract
  • limawoodextract
  • pernambucoextract
  • BRAZILIN (C.I. 75280)
  • CI 75280
  • BRAZILIN
  • superbresiline
  • Benz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol,7,11b-dihydro-, (6aS,11bR)-
  • Brazilin, 98%, from Caesalpinia sappanL.
  • Brazilin(6CI)
  • enz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol,7,11b-dihydro-,(6aS-cis)-(7CI,8CI)
  • razilin
  • (6aS,11bR)-7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol
  • NSC 56652
  • 7,11b-dihydroindeno[2,1-c]chromene-3,6a,9,10(6H)-tetrol
  • Brazilin >=98% (HPLC)
  • (+)-Brazilin
  • (6aS,11bR)-6,6a,7,11b-tetrahydroindeno[2,1-c]chromene-3,6a,9,10-tetraol
  • Arginine Impurity 3 Hydrochloride (Arginine EP Impurity C Hydrochloride)(Ornithine Hydrochloride)
  • (6aS,11bR)-7,11b-Dihydroindeno[2,1-c]chromene-3,6a,9,10(6H)-tetraol
  • Brazilin-RM
  • 474-07-7
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract