ChemicalBook > CAS DataBase List > Mestinon

Mestinon

Product Name
Mestinon
CAS No.
101-26-8
Chemical Name
Mestinon
Synonyms
PYRIDOSTIGMINE BROMIDE;PYBR;3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE;kalymin;regonal;kalimin;ro1-5130;mestinon;3-Hydroxy-1-;mestinonbromide
CBNumber
CB9356274
Molecular Formula
C9H13BrN2O2
Formula Weight
261.12
MOL File
101-26-8.mol
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Mestinon Property

Melting point:
154 °C
storage temp. 
2-8°C
solubility 
Very soluble in water and in ethanol (96 per cent).
form 
Solid
color 
White to Almost white
Merck 
14,7977
BCS Class
3
InChIKey
VNYBTNPBYXSMOO-UHFFFAOYSA-M
CAS DataBase Reference
101-26-8(CAS DataBase Reference)
EPA Substance Registry System
Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28-43
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
UU5270000
HazardClass 
6.1
PackingGroup 
II
HS Code 
2933399090
Hazardous Substances Data
101-26-8(Hazardous Substances Data)
Toxicity
man,TDLo,oral,9mg/kg (9mg/kg),PERIPHERAL NERVE AND SENSATION: FASCICULATIONS,Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P9797
Product name
Pyridostigmine bromide
Packaging
1g
Price
$53.6
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3120
Product name
Pyridostigmine Bromide
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$182
Updated
2024/03/01
Sigma-Aldrich
Product number
BP1033
Product name
Pyridostigmine bromide
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
50MG
Price
$247
Updated
2024/03/01
Sigma-Aldrich
Product number
1586009
Product name
Pyridostigmine bromide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
P1339
Product name
Pyridostigmine Bromide
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$37
Updated
2024/03/01
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Mestinon Chemical Properties,Usage,Production

Description

Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.

Chemical Properties

White Solid

Uses

Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.

Definition

ChEBI: Pyridostigmine bromide is a pyridinium salt.

brand name

Mestinon (Valeant); Regonol (Sandoz).

General Description

Pyridostigmine bromide,3-hydroxy-1-methylpyridinium bromide dimethylcarbamateor pyridostigmine bromide (Mestinon), occurs as a white, hygroscopic,crystalline powder with an agreeable, characteristicodor. It is freely soluble in water, alcohol, and chloroform.
Pyridostigmine bromide is about one fifth as toxic asneostigmine. It appears to function in a manner similar tothat of neostigmine and is the most widely used anticholinesteraseagent for treating myasthenia gravis. Theliver enzymes and plasma cholinesterase metabolize thedrug. The principal metabolite is 3-hydroxy-N-methylpyridinium.Orally administered pyridostigmine has a half-lifeof 90 minutes and a duration of action of between 3 and6 hours.

Biochem/physiol Actions

Acetylcholinesterase inhibitor.

Clinical Use

Myasthenia gravis

Drug interactions

Potentially hazardous interactions with other drugs
Aminoglycosides, clindamycin and polymyxins antagonise effects of pyridostigmine.

Metabolism

Pyridostigmine undergoes hydrolysis by cholinesterases and is also metabolised in the liver. It appears that 75% of the plasma clearance of pyridostigmine depends on renal function. 3-Hydroxy-N-methylpyridinium has been identified as one of the 3 metabolites isolated from the urine. Pyridostigmine is excreted mainly in the urine as unchanged drug and metabolites.

Mestinon Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mestinon manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mestinon 101-26-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%-101%;EP
Supply Ability
500 KG
Release date
2021-06-03
Baoji Guokang Bio-Technology Co., Ltd.
Product
Mestinon 101-26-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2021-06-03
Baoji Guokang Healthchem co.,ltd
Product
Mestinon 101-26-8
Price
US $420.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2021-06-02

101-26-8, MestinonRelated Search:

4-Hydroxybenzoic acid 3-Hydroxybenzoic acid 2'-Hydroxy-3-phenylpropiophenone Zinc picolinate PYRAZOPHOS Dimethyl phthalate Dimethyl isophthalate Sodium bromate Rocuronium bromide Vecuronium bromide 2-Picolinic acid Allyl bromide Chromium picolinate Dimidium bromide Rivastigmine 3-Dimethylaminopropylamine CARBONYL SULFIDE Methylparaben

  • (1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate
  • mestinonbromide
  • mestinonebromide
  • pyridinium,3-hydroxy-1-methyl-,bromide,dimethylcarbamate(ester)
  • pyridinium,3-hydroxyl-1-methyl-,bromide,dimethylcarbamate
  • regonal
  • ro1-5130
  • PYRIDOSTIGMINE BROMIDE
  • PYBR
  • 1-methyl-3-hydroxypyridiniumbromidedimethylcarbamate
  • Pyridostigminebromide(NTPB)
  • PYRIDOSTIGMINEBROMIDE,USP
  • Pyridostigminbromid
  • (1-Methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate bromide
  • 2-Propan-2-ylsulfanylethanol
  • 3-Hydroxy-1-
  • N,N-dimethylcarbamic acid (1-methylpyridin-1-ium-3-yl) ester bromide
  • PyridostigminebromideBP/USP
  • PYRIDOSTIGMINE BROMIDE CHOLINESTERASE IN HIBI
  • Pyridostigmine bromide,3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide
  • Pyridostigmine Bromide (200 mg)
  • Pyridostigmine Bromide (200 mg)I0C3240.999mg/mg(dr)
  • 3-diMethylaMino pyridine acyloxy
  • 3-(((dimethylamino)carbonyl)oxy)-1-methyl-pyridiniubromide
  • 3-(dimethylcarbamyloxy)-1-methylpyridiniumbromide
  • 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate
  • 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate(ester)
  • dimethylcarbamicacidesterof3-hydroxy-1-methylpyridiniumbromide
  • kalimin
  • kalymin
  • 3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE
  • 3-(DIMETHYLAMINOCARBONYLOXY)-1-METHYLPYRIDINIUM BROMIDE
  • 3-DIMETHYLAMINOCARBONYLOXY-N-METHYL-PYRIDINIUM BROMIDE
  • mestinon
  • 3-[(diMethylcarbaMoyl)oxy]-1-Methylpyridin-1-iuM
  • 3-[[(DiMethylaMino)carbonyl]oxy]-1-MethylpyridiniuM BroMid
  • 3-((diMethylcarbaMoyl)oxy)-1-Methylpyridin-1-iuM broMide
  • PyridostigMine BroMide (Mestinon)
  • BroMine pyridostigMine
  • Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1)
  • Pyridostigmine bromide CRS
  • [2H6]-Pyridostigmine Bromide
  • Mestinon USP/EP/BP
  • Pyridostigmine bromide (P4099900)
  • Pyridostigmine D6 BromideQ: What is Pyridostigmine D6 Bromide Q: What is the CAS Number of Pyridostigmine D6 Bromide Q: What is the storage condition of Pyridostigmine D6 Bromide Q: What are the applications of Pyridostigmine D6 Bromide
  • Pyridostigmine Bromide (1586009)
  • 2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1
  • 2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid
  • 4-dihydropyridine-3-carboxylic acid
  • Pyridamine bromide
  • Pyridostigmine Bromide, ≥ 98.0%
  • 101-26-8
  • C9H13BrN2O2
  • Pyridinium Compounds
  • Pharmaceutical raw material
  • API
  • MESTINON
  • Pyridinium Compounds