Meclizine dihydrochloride
- Product Name
- Meclizine dihydrochloride
- CAS No.
- 1104-22-9
- Chemical Name
- Meclizine dihydrochloride
- Synonyms
- diadril;bonamine;NSC 28728;Navidoxine;Meclozine Hcl;)-4-(3-methyL;Meclizine 2HCl;Meclizine diHCl;Meclozine ,Bonamine;ancolandihydrochloride
- CBNumber
- CB9362486
- Molecular Formula
- C25H29Cl3N2
- Formula Weight
- 463.87
- MOL File
- 1104-22-9.mol
Meclizine dihydrochloride Property
- Melting point:
- 210.0 to 214.0 °C
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- CAS DataBase Reference
- 1104-22-9(CAS DataBase Reference)
- EPA Substance Registry System
- Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0950
- Product name
- Meclizine dihydrochloride
- Purity
- ≥97% (HPLC)
- Packaging
- 50mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- M0220000
- Product name
- Meclozine dihydrochloride
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- m0220000
- Price
- $150
- Updated
- 2024/03/01
- Product number
- BP220
- Product name
- Meclozine hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $266
- Updated
- 2024/03/01
- Product number
- M2755
- Product name
- Meclizine Dihydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $71
- Updated
- 2024/03/01
- Product number
- M2755
- Product name
- Meclizine Dihydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 25g
- Price
- $210
- Updated
- 2023/06/20
Meclizine dihydrochloride Chemical Properties,Usage,Production
Description
Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Chemical Properties
White or yellowish-white, slightly hygroscopic, crystalline powder.
Originator
Antivert,Roerig,US,1957
Uses
Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.
Uses
Antiemetic;Histamine antagonist
Uses
cholinergic, diagnostic aid
Manufacturing Process
32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This
solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The
solvent is evaporated and the residue is distilled under high vacuum. The
product of the condensation distills near 230°C at 2 mm Hg pressure and the
corresponding dihydrochloride melts at 217° to 224°C.
brand name
Antivert (Pfizer).
Therapeutic Function
Antinauseant
Biochem/physiol Actions
Meclizine has the ability to increase glycolysis and decrease cellular ATP levels in media that has glucose and galactose. It guards the kidney against ischemia-reperfusion injury. Meclizine is considered as an anti-nausea and anti-dizziness drug, was identified in a ′nutrient-sensitized′ chemical screen. In human, it acts as an agonist of pregnane X receptor (PXR). It enhances the expression of CYP3A4 (cytochrome P450 3A4) mRNA and reduces CYP3A-catalyzed testosterone 6β-hydroxylation in primary cultures of human hepatocytes.
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.
Solubility in organics
Meclizine dihydrochloride is readily soluble in chloroform and pyridine, slightly soluble in dilute acids and ethanol, and insoluble in water or ether.
storage
Desiccate at RT
Meclizine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Meclizine dihydrochloride Suppliers
- Tel
- --
- Fax
- --
- sales@darmerica.com
- Country
- Canada
- ProdList
- 964
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- Canada
- ProdList
- 31
- Advantage
- 58
- Tel
- --
- Fax
- --
- kevinl@syntechpharmachem.com
- Country
- Canada
- ProdList
- 386
- Advantage
- 58
View Lastest Price from Meclizine dihydrochloride manufacturers
- Product
- Meclizine dihydrochloride 1104-22-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Meclizine dihydrochloride 1104-22-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Meclizine dihydrochloride 1104-22-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-16