3-(4-METHYLBENZYLIDENE)CAMPHOR
- Product Name
- 3-(4-METHYLBENZYLIDENE)CAMPHOR
- CAS No.
- 36861-47-9
- Chemical Name
- 3-(4-METHYLBENZYLIDENE)CAMPHOR
- Synonyms
- 4-METHYLBENZYLIDENE CAMPHOR;Enzacamene;PARSOL 5000;3-(4-METHYLBENZYLIDINE)CAMPHOR;MBC 95;UV 4MBC;MEXORYLSD;NEO-HELIOPAN;Zinc01481820;EUSOLEX 6300
- CBNumber
- CB9366893
- Molecular Formula
- C18H22O
- Formula Weight
- 254.37
- MOL File
- 36861-47-9.mol
3-(4-METHYLBENZYLIDENE)CAMPHOR Property
- Melting point:
- 66-68°C
- Boiling point:
- 198-200 °C
- Density
- 1.064±0.06 g/cm3(Predicted)
- RTECS
- DT5099565
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- insoluble in H2O; ≥10 mg/mL in DMSO; ≥111.2 mg/mL in EtOH
- form
- Solid
- color
- White to off-white
- BRN
- 9213949
- LogP
- 3.385 (est)
- CAS DataBase Reference
- 36861-47-9(CAS DataBase Reference)
- EPA Substance Registry System
- Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]- (36861-47-9)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 63
- Safety Statements
- 22-24/25-36/37
- WGK Germany
- 2
- TSCA
- Yes
- HS Code
- 2914399000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR2805
- Product name
- Methyl Benzylidene Camphor
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 400MG
- Price
- $182
- Updated
- 2024/03/01
- Product number
- 61547
- Product name
- 3-(4-Methylbenzylidene)camphor
- Purity
- certified reference material, TraceCERT
- Packaging
- 50mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 1424222
- Product name
- Methyl benzylidene camphor
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 13840
- Product name
- 4-Methylbenzylidene camphor
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 13840
- Product name
- 4-Methylbenzylidene camphor
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $537
- Updated
- 2024/03/01
3-(4-METHYLBENZYLIDENE)CAMPHOR Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
3-(4-Methylbenzyliden)camphor is an UV-B absorbing agent in sunscreen cosmetics of the type creams, lotions, lipsticks, sun oils, etc.
Uses
3-(4-Methylbenzylidene)camphor is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. 4-Methylbenzylidene camphor(4-MBC) a UV-B ray filter, is an endocrine disruptors (ED).
Uses
4-(Methylbenzylidene)camphor (4-MBC), a UV-B ray filter, is an endocrine disruptors (ED).
Biological Activity
4-methylbenzylidene camphor (4-mbc) is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.since the estrogen receptor (er) ligand type can influence transactivation, it is important to obtain information on molecular actions of nonclassical er agonists.
in vitro
previous results of competitive binding assays using cytosolic protein preparations from xenopus hepatocytes demonstrated that 4-mbc could weakly bind to the er. in addition, 4-mbc at a 100 micromol/l was not able to replace estradiol from the receptor completely [1].
in vivo
the estrogen target gene expression in uterus of long evans rats after exposure to 4-mbc was studied. results showed that 4-mbc could altere steady-state levels of mrnas encoding for er, progesterone receptor (pr), and androgen recepto in uterus of 12-wk-old offspring. to evaluate sensitivity to estradiol (e2), offspring were injected with e2, and killed 6 h later. acute up-regulation of pr and igf-i and down-regulation of er and androgen receptor by e2 were reduced in 4-mbc treated rats dose-dependently [2].
References
[1] klann a, levy g, lutz i, müller c, kloas w, hildebrandt jp. estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells. environ res. 2005 mar;97(3):274-81.
[2] s. durrer, k. maerkel, m. schlumpf, et al. estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. endocrinology 146(5), 2130-2139 (2005).
[3] n. r. janjua, b. mogensen, a. m. andersson, et al. systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. journal of investigative dermatology 123, 57-61(2004).
3-(4-METHYLBENZYLIDENE)CAMPHOR Preparation Products And Raw materials
Raw materials
Preparation Products
3-(4-METHYLBENZYLIDENE)CAMPHOR Suppliers
- Tel
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- webmestre-substances@ineris.fr
- Country
- France
- ProdList
- 6024
- Advantage
- 58
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- interchim@interchim.com
- Country
- France
- ProdList
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View Lastest Price from 3-(4-METHYLBENZYLIDENE)CAMPHOR manufacturers
- Product
- 4-Methylbenzylidene Camphor 36861-47-9
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-14
- Product
- 3-(4'-Methylbenzylidene)camphor 36861-47-9
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500kg
- Release date
- 2021-11-05
- Product
- 3-(4-METHYLBENZYLIDENE)CAMPHOR 36861-47-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24