4-BROMO-2-METHYL-1-NITROBENZENE
- Product Name
- 4-BROMO-2-METHYL-1-NITROBENZENE
- CAS No.
- 52414-98-9
- Chemical Name
- 4-BROMO-2-METHYL-1-NITROBENZENE
- Synonyms
- 3-Bromo-6-nitrotoluene;5-Bromo-2-nitrotoluene 98%;2-Methyl-4-bromonitrobenzene;4-BroMo-2-Methylnitrobenzene;4-Bromo-6-methylnitrobenzene;5-Bromo-1-methyl-2-nitrobenzene;4-BROMO-2-METHYL-1-NITROBENZENE;Benzene,4-broMo-2-Methyl-1-nitro-;2-(3-bromo-2-nitrophenyl)acetonitrile;4-Bromo-2-methyl-1-nitrobenzene, 4-Bromo-2-methylnitrobenzene
- CBNumber
- CB9370708
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 52414-98-9.mol
4-BROMO-2-METHYL-1-NITROBENZENE Property
- Melting point:
- 53-55℃
- Boiling point:
- 265℃
- Density
- 1.615
- refractive index
- 1.6120 (estimate)
- Flash point:
- 114℃
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2929900090
N-Bromosuccinimide Price
- Product number
- B698095
- Product name
- 5-Bromo-2-nitrotoluene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B698095
- Product name
- 5-Bromo-2-nitrotoluene
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B698095
- Product name
- 5-Bromo-2-nitrotoluene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR60239
- Product name
- 5-Bromo-2-nitrotoluene
- Purity
- 98%
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 4754-9-X8
- Product name
- 5-Bromo-2-nitrotoluene
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
4-BROMO-2-METHYL-1-NITROBENZENE Chemical Properties,Usage,Production
Uses
5-Bromo-2-nitrotoluene is used the synthesis of biphenylamide derivatives as Hsp90 C-terminal inhibitor for the treatment of cancer and neurodegenerative diseases.
Synthesis
583-75-5
52414-98-9
General procedure for the synthesis of 4-bromo-2-methyl-1-nitrobenzene from 2-methyl-4-bromoaniline: Step 1: Synthesis of 4-bromo-2-methyl-1-nitrobenzene (193) H2O2 (3.95 mL, 64±5 mmol) was dissolved in DCM (320 mL) at 0°C, cooled and TFAA (10.93 mL, 77 mmol) was added and the mixture was stirred for 5 min at this temperature. The ice bath was then removed, a reflux condenser was installed, and a solution of 4-bromo-2-methylaniline (3 g, 16.12 mmol) in DCM (6.4 mL) was added slowly and dropwise over about 30 minutes. The reaction mixture was heated to reflux for 1 h. After cooling, the reaction mixture was washed sequentially with 30 mL of water and 30 mL of saturated NaHCO3 solution, and the organic layer was dried with MgSO4 and concentrated in vacuum. The crude product was purified by flash column chromatography to give 193 (2.57 g, 11.9 mmol, 74% yield). 1H NMR (CDCl3) δ (ppm): 7.88 (d, J = 8.6 Hz, 1H), 7.53 (d, J = 2.2 Hz, 1H), 7.49 (dd, J = 8.6, 2.2 Hz, 1H), 2.60 (s, 3H).
References
[1] Patent: WO2008/104077, 2008, A1. Location in patent: Page/Page column 122
[2] Journal of Organic Chemistry, 1955, vol. 20, p. 1458
[3] Patent: US4287201, 1981, A
4-BROMO-2-METHYL-1-NITROBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-2-METHYL-1-NITROBENZENE Suppliers
- Tel
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- Fax
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- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 4-BROMO-2-METHYL-1-NITROBENZENE manufacturers
- Product
- 4-BROMO-2-METHYL-1-NITROBENZENE 52414-98-9
- Price
- US $80.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-27
- Product
- 4-BROMO-2-METHYL-1-NITROBENZENE 52414-98-9
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08