Eprazinone dihydrochloride
- Product Name
- Eprazinone dihydrochloride
- CAS No.
- 10402-53-6
- Chemical Name
- Eprazinone dihydrochloride
- Synonyms
- 746CE;Mucitux;Eftapan;Resplen;Rozuplen;NSC 317935;Eprazinone 2HCl;Eprazinone diHCl;EPRAZINONE HYDROCHLORIDE;Eprazinone 2hydrochloride
- CBNumber
- CB9371811
- Molecular Formula
- C24H33ClN2O2
- Formula Weight
- 416.99
- MOL File
- 10402-53-6.mol
Eprazinone dihydrochloride Property
- Melting point:
- 201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
Safety
- Toxicity
- LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 448353
- Product name
- Eprazinone Dihydrochloride
- Packaging
- 50mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- E590020
- Product name
- EprazinoneDihydrochloride
- Packaging
- 250mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- CS-0019683
- Product name
- Eprazinonedihydrochloride
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 94335
- Product name
- Eprazinone Dihydrochloride
- Packaging
- 50mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- CS-0019683
- Product name
- Eprazinonedihydrochloride
- Packaging
- 500mg
- Price
- $380
- Updated
- 2021/12/16
Eprazinone dihydrochloride Chemical Properties,Usage,Production
Originator
Mucitux,Riom,France,1969
Uses
Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.
Definition
ChEBI: A hydrochloride obtained by combining eprazinone with two molar equivalents of hydrochloric acid.
Manufacturing Process
61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g
(0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and
0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The
product is allowed to crystallize, then filtered and washed with alcohol. It is
dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water.
Yield: 66%. Melting point: 160°C.
Therapeutic Function
Antitussive
Eprazinone dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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